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7 results for “L-leucine”
Oxidation of L-leucine amino acid initiated by HO● radical - Are transition metal ions an enhancement factor?
<p class="MsoNormal"><span><span>Hydroxyl radical (HO<sup>●</sup>) formation initiated by the Fenton-type reactions of Fe and Cu complexes of L-leucine (Leu) amino acid, as well as its oxidation reaction by HO<sup>●</sup> were computationally investigated by using the density functional theory (DFT) method at the M05-2X/6-311++G(3df,2pd)//M05-2X/6-311++G(d,p) level of theory in the aqueous phase. The results showed that dipole-salt is the main form of Leu in the physiological condition. Leu exhibits high chelating potential towards both Fe(III)/Fe(II) and Cu(II)/Cu(I) ions with the most favorable coordinating positions at two oxygen atoms of the –COO functional groups. Furthermore, the Leu-ions complexes show a high risk of HO<sup>●</sup> formation <em><span>via</span></em> Fenton-like reactions, especially when ascorbate anion exists in the environment as a reducing agent. Finally, the oxidation reaction of L-leucine by HO<sup>●</sup> demonstrated a relatively high overall apparent reaction rate – </span><em><span>k<sub>overall</sub></span></em><span><span> being 1.18 × 10<sup>9</sup> M<sup>-1</sup>s<sup>-1</sup>,</span><span> </span><span>in which</span><span> </span><span>formal hydrogen transfer (FHT) reactions of the dipole-salt form occur as the primary mechanism. Consequently, the Leu oxidation by HO<sup>●</sup> radical can be promoted by the Fenton-reaction enhancement of its transition metal complexes.</span></span></span></p>
Data for: Invasive investigation: Uptake and transport of L-leucine in the gill epithelium of crustaceans
<p><span>Many aquatic species are well-known as extremely successful invaders. The green crab (<em>Carcinus</em> <em>maenas</em>) is an arthropod native to European waters; however, it is now known to be a globally invasive species. Recently it was discovered that <em>C. maenas</em> could transport nutrients in the form of amino acids across their gill from the surrounding environment, a feat previously thought to be impossible in arthropods. We compared the ability for branchial amino acid transport of crustaceans native to Canadian Pacific waters to that of the invasive <em>C. maenas</em>, determining if this was a novel pathway in an extremely successful invasive species or a shared trait among crustaceans. Active transport of L-leucine was exhibited in C<em>arcinus maenas, Metacarcinus gracilis, Metacarcinus magister</em>, and <em>Cancer</em> <em>productus</em> across their gill epithelia. <em>C. maenas</em> exhibited the highest maximum rate of branchial L-leucine transport at 53.7 ± 6.24 </span>nmolg<sup>-1</sup>h<sup>-1</sup>, over twice the rate of two native Canadian crustaceans<span>. We also examined the influence of feeding, gill specificity, and organ accumulation of L-leucine. Feeding events displayed a heavy influence on the branchial transport rate of amino acids, increasing L-leucine transport rates by up to 10-fold in <em>C. maenas</em>. L-leucine displayed </span>a significantly higher accumulation rate <span>in the gills of <em>C. maenas</em> </span>compared to the rest of the body <span>at </span>4.15 <span>± 0.78 </span>nmolg<sup>-1</sup>h<sup>-1</sup>, with the stomach, hepatopancreas, eyestalks, muscle tissue, carapace, and heart muscle exhibiting accumulation under 0.15 nmolg<sup>-1</sup>h<sup>-1</sup>. <span>For the first time, the novel transport of amino acids in Canadian native arthropods is described, suggesting that branchial amino acid transport is a shared trait among arthropods, contrary to existing literature. Further investigation is required to determine the influence of environmental temperature and salinity on transport in each species to outline any competitive advantages of the invasive <em>C. maenas</em> in a fluctuating estuarine environment. </span></p>
Effects of Intragastric Quinine, Alone or Combined With L-leucine, on Postprandial Glycaemic Control
ClinicalTrials.gov study NCT05720390. IPD Sharing: NO. Countries: 1. Publications: 1.
Data for: Invasive investigation: Uptake and transport of L-leucine in the gill epithelium of crustaceans
Open the record for dataset details and reuse information.
Oxidation of L-leucine amino acid initiated by HO● radical - Are transition metal ions an enhancement factor?
Open the record for dataset details and reuse information.
L-leucine in Diamond Blackfan Anemia Patients
ClinicalTrials.gov study NCT02386267. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Improved transcription and translation with L-leucine stimulation of mTORC1
GEO Series GSE64962. Homo sapiens. 42 samples. Type: Expression profiling by high throughput sequencing.
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