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13 results for “L-proline”
Revisiting the HO●-initiated oxidation of L-proline amino acid in the aqueous phase – Influence of transition metal ions
<p>The oxidation of L-proline (Pro) by HO<sup>●</sup> radical in water and the influence of transition metal ions on this process has been revisited by using the density functional theory (DFT) method at the M05-2X/6-311++G(3df,3pd)//M05-2X/6-311++G(d,p) level of theory at the temperature of 298.15 K. HO<sup>●</sup>-initiated oxidation of Pro via hydrogen atom transfer (HAT) reactions is more favourable at the b- and g-carbon than at the a- and d-carbon. The total branching ratios are 44.6% and 39.5% for the β- and γ-carbon and 11.5% and 4.2% for the a- and d-carbon, respectively. The overall rate constant at 298.15 K is 6.04 × 10<sup>8</sup> M<sup>-1</sup> s<sup>-1</sup>. In addition, Pro tends to form the stable mono- and bi-dentate complexes with both Fe and Cu ions via the –COO functional group of dipole-salt form. The most stable Cu(II)-Pro complexes have high potential oxidant risks by enhancing the HO<sup>●</sup> radical formation in the presence of reducing agents such as superoxide anion or ascorbate anion. Besides, the complexes of the metal at a high oxidation state, i.e., Fe(III)-Pro and Cu(II)-Pro, show their ability to be oxidized by HO<sup>●</sup> radical via HAT reactions but with a lower rate constant than that of free Pro. Unsurprisingly, the oxidation enhancement is insignificant for SET reactions with almost negligible rate constants. In contrast, the rate constants of SET reactions of low oxidation state complexes (i.e., Fe(II)-Pro and Cu(I)-Pro) are faster than the oxidation rate of free ligands, and thus, these complexes promote the oxidation of Pro.</p>
Sensing of extracellular L-Proline availability by the integrated stress response determines the outcome of cell competition
Open the record for dataset details and reuse information.
Revisiting the HO●-initiated oxidation of L-proline amino acid in the aqueous phase – Influence of transition metal ions
Open the record for dataset details and reuse information.
Signalling pathway crosstalk stimulated by L-proline drives mouse embryonic stem cells
<p>Contains data and R code to reproduce paper models, statistics and plots</p>
Electron Diffraction (MicroED) Datasets for Ipragliflozin L-Proline (Glacios TEM with a CETA-D)
<p>Electron diffraction datasets collected from ipragliflozin L-proline, a chiral pharmaceutical cocrystal.</p> <p> </p> <p>Microscope: Thermo Fisher Scientific Glacios Transmission Electron Microscope (SDC1G at NanoImaging Services)</p> <p>Camera: Ceta-D camera (bin 2x2, rolling shutter, noise reduction mode)</p> <p>Collection Software: Leginon (Cheng, et. al. 2021)*</p> <p>Collection Parameters: 200keV, -193C, 20um C2, gun lens 7.1, spot size 10, parallel beam, calibrated camera length 1065.7mm (1100 in UI), oscillation per frame 0.89deg, 222ms exposure time, tilt speed 4 deg/s, rotation -60 to +60 (first ~8 degrees not recorded)</p> <p>Grid: Ted Pella 01840</p> <p>Sample: Ipragliflozin (C<sub>21</sub>H<sub>21</sub>FO<sub>5</sub>S, (2S,3R,4R,5S,6R)-2-{3-[(1-benzothiophen-2-yl)methyl]-4-fluorophenyl}-6-(hydroxymethyl)oxane-3,4,5-triol) and L-proline (C<sub>5</sub>H<sub>9</sub>NO<sub>2, </sub>(2S)-pyrrolidine-2-carboxylic acid)</p> <p>Structure: CCDC 2174023</p> <p> </p> <p>* Data have been converted to SMV format with the addition of an offset value to remove negative pixel values. This offset value can be found in the image headers, along with a suggested pedestal value.</p> <p> </p> <p>A data processing tutorial is available for processing data collected with this setup using DIALS: </p> <p><a href="https://dials.github.io/documentation/tutorials/3DED/Biotin.html">https://dials.github.io/documentation/tutorials/3DED/Biotin.html</a></p> <p> </p> <p>Funding: NIH/NIGMS grant number 1R44GM140666</p>
Effect of L-Proline on mouse embryonic stem cells (ESCs)
GEO Series GSE50477. Mus musculus. 5 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Vitamin C and L-Proline antagonistic effects capture alternative states in the pluripotency continuum
GEO Series GSE84373. Mus musculus. 22 samples. Type: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing.
Impaired Insulin-/IGF1-Signaling Extends Life Span by Promoting Mitochondrial L-Proline Catabolism to Induce a Transient ROS-Signal
GEO Series GSE36041. Caenorhabditis elegans; Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
Vitamin C and L-Proline antagonistic effects capture alternative states in the pluripotency continuum [RNA-Seq]
GEO Series GSE84137. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
Vitamin C and L-Proline antagonistic effects capture alternative states in the pluripotency continuum [RRBS]
GEO Series GSE84372. Mus musculus. 8 samples. Type: Methylation profiling by high throughput sequencing.
Effect of L-Proline on mouse embryonic stem cells (ESCs)
GEO Series GSE50603. Mus musculus. 12 samples. Type: Expression profiling by array.
Transcriptomic Profiling of L-Proline Induced Ferroptosis Reveals PPARγ-Mediated Regulatory Networks in HFpEF Progression
GEO Series GSE308324. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Comparison of the expression profiles of the 630E (JIR8094) strain and a prdR mutant (LB-CD8) after 4h growth in TY supplemented with L-proline
GEO Series GSE42471. Clostridioides difficile. 2 samples. Type: Expression profiling by array.
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