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50 results for “LEF1”
A distinct isoform of lymphoid enhancer binding factor 1 (LEF1) epigenetically restricts EBV reactivation to maintain viral latency
<p>As a human tumor virus, EBV is present as a latent infection in its associated malignancies where genetic and epigenetic changes have been shown to impede cellular differentiation and viral reactivation. We reported previously that levels of the Wnt signaling effector, lymphoid enhancer binding factor 1 (LEF1) increased following EBV epithelial infection and an epigenetic reprogramming event was maintained even after loss of the viral genome. Elevated LEF1 levels are also observed in nasopharyngeal carcinoma and Burkitt lymphoma. To determine the role played by LEF1 in the EBV life cycle, we used in silico analysis of EBV type 1 and 2 genomes to identify over 20 Wnt-response elements, which suggests that LEF1 may bind directly to the EBV genome and regulate the viral life cycle. Using CUT&RUN-seq, LEF1 was shown to bind the latent EBV genome at various sites encoding viral lytic products that included the immediate early transactivator BZLF1 and viral primase BSLF1 genes. The LEF1 gene encodes various long and short protein isoforms. siRNA depletion of specific LEF1 isoforms revealed that the alternative-promoter derived isoform with an N-terminal truncation (∆N LEF1) transcriptionally repressed lytic genes associated with LEF1 binding. In addition, forced expression of the ∆N LEF1 isoform antagonized EBV reactivation. As LEF1 repression requires histone deacetylase activity through either recruitment of or direct intrinsic histone deacetylase activity, siRNA depletion of LEF1 resulted in increased histone 3 lysine 9 and lysine 27 acetylation at LEF1 binding sites and across the EBV genome. Taken together, these results indicate a novel role for LEF1 in maintaining EBV latency and restriction viral reactivation via repressive chromatin remodeling of critical lytic cycle factors.</p>
A distinct isoform of lymphoid enhancer binding factor 1 (LEF1) epigenetically restricts EBV reactivation to maintain viral latency
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Tcf1 and Lef1 transcription factors underpin the inception of T cell fate
GEO Series GSE283601. Mus musculus. 8 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
The transcription factors TCF1 and LEF1 promote B-1a cell homeostasis and regulatory function.
GEO Series GSE290505. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
The transcription factors TCF1 and LEF1 promote B-1a cell homeostasis and regulatory function.
GEO Series GSE298030. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing; Other.
RNA-Seq of LEF1 overexpression ECA109 cells
GEO Series GSE128914. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Impact of Tcf1 and Lef1 deficiency on follicular helper T (Tfh) cells
GEO Series GSE66781. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
The transcriptional regulator Prdm1 is a master gene for the early development of the sensory whisker follicle and is wired to the Lef1 circuitry [CUT&TAG]
GEO Series GSE192851. Mus musculus. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
The transcriptional regulator Prdm1 is a master gene for the early development of the sensory whisker follicle and is wired to the Lef1 circuitry.
GEO Series GSE193357. Mus musculus. 10 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Other.
Tcf1 and Lef1 regulate follicular helper T cell function eliciated by vaccination [RNA-Seq]
GEO Series GSE146425. Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing.
Analyzing the effect of Lef1 deletion in mouse intestinal organoids with single-cell RNA sequencing
GEO Series GSE179853. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Impact of Tcf1 and Lef1 deficiency on HSCs
GEO Series GSE60587. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Impact of Lef1 overexpression on follicular helper T (Tfh) differentiation
GEO Series GSE67335. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
SNAIL1 employs β-Catenin-LEF1 complexes to control colorectal cancer cell invasion and proliferation
GEO Series GSE115716. Homo sapiens. 27 samples. Type: Expression profiling by array.
Analyzing the effect of Lef1 deletion in mouse intestinal adenoma cells with single-cell RNA sequencing
GEO Series GSE179483. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Deficient LEF1 expression is associated with lithium resistance and hyperexcitability in neurons derived from bipolar disorder patients
GEO Series GSE159487. Homo sapiens. 150 samples. Type: Expression profiling by high throughput sequencing.
Single cell analysis of Villin-Cre;Apc min;Lef1 fl/fl (VApcMinL) and ApcMin Epcam- cells and CD45-Epcam- stromal cells from lamina propria at the age of 11 wks.
GEO Series GSE173565. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Impact of Tcf1 and Lef1 deficiency on histone marks and Tcf1 binding in CD8 T cells
GEO Series GSE73239. Mus musculus. 17 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
RNA-Seq analysis LEF1 or KDM4A knockdown effect on CAL-27 cells
GEO Series GSE230372. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Lef1 Ablation Alleviates Cartilage Mineralization during Post-traumatic Osteoarthritis
GEO Series GSE200522. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.