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48 results for “LEUKOTRIENES”
Raw diffraction images of leukotriene B4 receptor BLT1
<p>Diffraction images of Leukotriene B<sub>4</sub> receptor (BLT1) in complex with antagonist BIIL260, a chemical bearing a benzamidine moiety. BLT1 is one of class-A G-protein coupled receptor (GPCR), and the bound benzamidine moiety mimics a sodium ion-centered water cluster of BLT1 that is considered to exist in many class-A GPCRs. The bound benzamidine moiety stabilizes the inactive state of BLT1, and BIIL260 exhibits the characteristics of an inverse agonist for BLT1.</p> <p>Small-wedge (1296 crystals, 2.5°/crystal) datasets collected from loop-harvested microcrystals using EIGER X 9M detector at a wavelength of 1 Å on BL32XU, SPring-8. The crystals belonged to space group P22<sub>1</sub>2<sub>1</sub> with unit cell parameters a=69.6, b=77.6, c=135.5 Å.</p> <p>Finally, 494 datasets were merged at 3.7 Å resolution in the published result (Hori et al. Nature Chemical Biology, 2018; PDB code: 5X33) using KAMO; see processing note https://github.com/keitaroyam/yamtbx/wiki/Processing-BLT1-data-(5X33)</p> <p>Note</p> <ul> <li>The master.h5 files were modified; see https://github.com/keitaroyam/yamtbx/blob/master/doc/eiger-en.md</li> <li>To further reduce total file size, flatfield data of master.h5 were removed and saved in a file in each directory (linked from master.h5 files).</li> <li>Most frames have lipid rings.</li> </ul>
Raw Diffraction Data of the Human Leukotriene B4 Receptor 1 in Complex with Antagonist MK-D-046
<p>The human leukotriene B4 receptor 1 (UniProt ID Q15722, residues 13-310), fused with flavodoxin (UniProt ID P00323), was crystallized in complex with antagonist MK-D-046. X-ray diffraction data was collected at the GM/CA beamline 23ID-B of the Advanced Photon Source (APS) in the Argonne National Laboratory, IL, USA using an Eiger-16M detector (Dectris). A total of 1,883 frames were recorded with an oscillation angle of 0.2 deg.</p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p> <div> </div>
The Leukotriene Modifier Or Corticosteroid or Corticosteroid-Salmeterol Trial
ClinicalTrials.gov study NCT00156819. IPD Sharing: Not stated. Countries: 1. Publications: 5.
A Safety Study of Xolair (Omalizumab) in Patients With Chronic Idiopathic Urticaria (CIU) Who Remain Symptomatic Despite Treatment With H1 Antihistamines, H2 Blockers, and/or Leukotriene Receptor Anta
ClinicalTrials.gov study NCT01264939. IPD Sharing: Not stated. Countries: 8. Publications: 6.
Leukotriene A4 hydrolase inhibition improves age related cognitive decline via modulation of synaptic function (Part 2/2)
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Leukotriene A4 hydrolase inhibition improves age related cognitive decline via modulation of synaptic function (Part 1/2)
Open the record for dataset details and reuse information.
Effects of Leukotriene Modulator Montelukast on Cough Variant Asthma
ClinicalTrials.gov study NCT01404013. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Leukotriene A4 Hydrolase Stratified Trial of Adjunctive Corticosteroids for HIV-uninfected Adults With Tuberculous Meningitis
ClinicalTrials.gov study NCT03100786. IPD Sharing: YES. Countries: 1. Publications: 64.
Leukotriene D4 Nasal Provocation Test in Allergic Rhinitis
ClinicalTrials.gov study NCT01963741. IPD Sharing: Not stated. Countries: 1. Publications: 15.
Efficacy of Oral Leukotriene in Long Term Therapy of Mild and Moderate Obstructive Sleep Apnea Syndrome in Children
ClinicalTrials.gov study NCT00912171. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Leukotriene D4 Bronchial Provocation Test (LTD4-BPT) as an Indicator for the Use of Leukotriene Receptor Antagonist (LTRA)
ClinicalTrials.gov study NCT01414868. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Leukotriene Receptor Antagonists or Steroids in Pre-School Asthma
ClinicalTrials.gov study NCT00543686. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Leukotriene Antagonism in Recruitment of CD49d Expressing Neutrophils in Atopic Subjects
ClinicalTrials.gov study NCT03039101. IPD Sharing: NO. Countries: 1. Publications: 8.
The Leukotriene Receptor Antagonist Montelukast in the Treatment of Non-alcoholic Steatohepatitis
ClinicalTrials.gov study NCT04080947. IPD Sharing: YES. Countries: 1. Publications: 1.
Breast Capsular Contracture Following Post-Mastectomy Reconstruction in Women Treated With the Leukotriene Inhibitor Zafirlukast: A Phase II Trial
ClinicalTrials.gov study NCT02950480. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Modification of Allergic Immunologic Response by Leukotriene Antagonists - Ancillary to ACRN IMPACT
ClinicalTrials.gov study NCT00021931. IPD Sharing: Not stated. Countries: 0. Publications: 4.
Targeting Leukotrienes in Kidney Disease
ClinicalTrials.gov study NCT05362474. IPD Sharing: NO. Countries: 1. Publications: 0.
Role of Cysteinyl Leukotrienes in the Pathogenesis of Asthma in Obesity
ClinicalTrials.gov study NCT01158573. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Murine anaphylaxis to food requires cysteinyl leukotriene-mediated absorption of allergens in the gut
GEO Series GSE261022. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Intestinal mast cell-derived leukotrienes mediate the anaphylactic response to ingested antigens
GEO Series GSE293906. Mus musculus. 26 samples. Type: Expression profiling by high throughput sequencing.
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.