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114 results for “Latent Tuberculosis”
Monoclonal antibodies from humans with Mycobacterium tuberculosis exposure or latent infection recognize distinct arabinomannan epitopes
<p>The surface polysacharide arabinomannan (AM) and related glycolipid lipoarabinomannan (LAM) play critical roles in tuberculosis pathogenesis. Human antibody responses to AM/LAM are heterogenous and knowledge of reactivity to specific glycan epitopes at the monoclonal level is limited, especially in individuals who can control <i><span>M. tuberculosis</span></i> infection<span>. </span>We generated human IgG mAbs to AM/LAM from B cells of two asymptomatic individuals exposed to or latently infected with <i><span>M. tuberculosis</span></i>. We here show that two of these mAbs have high affinity to AM/LAM, are non-competing, and recognize different glycan epitopes <span>distinct from other anti-AM/LAM mAbs reported. Both mAbs recognize virulent </span><i><span>M. tuberculosis</span></i><span> and nontuberculous mycobacteria with marked differences, can be used for the detection of urinary LAM, and can detect </span><i><span>M. tuberculosis</span></i><span> and LAM in infected lungs. These mAbs enhance our understanding of the spectrum of antibodies to AM/LAM epitopes </span>in humans <span>and</span> are valuable for <span>tuberculosis</span> diagnostic and research applications.</p>
A Phase I/IIa AERAS-456 in HIV-Negative Adults With & Without Latent Tuberculosis Infection (C-035-456)
ClinicalTrials.gov study NCT01865487. IPD Sharing: NO. Countries: 1. Publications: 1.
Study 33: Adherence to Latent Tuberculosis Infection Treatment 3HP SAT Versus 3HP DOT
ClinicalTrials.gov study NCT01582711. IPD Sharing: Not stated. Countries: 4. Publications: 7.
Screening for Latent Tuberculosis Infection (LTBI) in US Army Recruits
ClinicalTrials.gov study NCT00804713. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Monoclonal antibodies from humans with Mycobacterium tuberculosis exposure or latent infection recognize distinct arabinomannan epitopes
Open the record for dataset details and reuse information.
Data and Scripts for "Timing matters in Macrophage / CD4+ T cell interactions: An agent-based model comparing Mycobacterium tuberculosis host-pathogen interactions between latently infected and naïve individuals"
<p>This contains the data and graphing scripts necessary to recreate all figures in the paper "Timing matters in Macrophage / CD4+ T cell interactions: An agent-based model comparing Mycobacterium tuberculosis host-pathogen interactions between latently infected and naïve individuals". Supplemental Material for the paper is also provided here. Please refer to the README.md for instructions on how to use. The model can be found at: https://github.itap.purdue.edu/ElsjePienaarGroup/LTBINaiveinvitroModel/ along with the uncalibrated parameter files and scripts to run on HPCs.</p>
Patients With Tuberculosis, Mycobacteriosis or Latent Tuberculosis
ClinicalTrials.gov study NCT06764576. IPD Sharing: NO. Countries: 1. Publications: 11.
Rifampin Versus Isoniazid for the Treatment of Latent Tuberculosis Infection in Children (P4v9)
ClinicalTrials.gov study NCT00170209. IPD Sharing: UNDECIDED. Countries: 7. Publications: 7.
New Strategies for Assessment of the Persistence of Viable Bacilli in Latent and Active Tuberculosis
ClinicalTrials.gov study NCT05621343. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Short-Course Isoniazid and Rifampin Compared With Isoniazid for Latent Tuberculosis Infection
ClinicalTrials.gov study NCT00397709. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Treatment of Latent Tuberculosis Infection With Isoniazid
ClinicalTrials.gov study NCT00293228. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Clinical Practice Guidelines Versus Decision-support for Latent Tuberculosis Infection (LTBI) Management
ClinicalTrials.gov study NCT05772065. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study to Evaluate the Tolerability and Immunogenicity of Nyaditum Resae ® Probiotic Administered to Pediatric Population in Contact With Tuberculosis With or Without Latent Tuberculosis Infection
ClinicalTrials.gov study NCT02581579. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Clinical Analysis of Safety in Latent Tuberculosis Infection Prophylaxis Treatment
ClinicalTrials.gov study NCT04655794. IPD Sharing: NO. Countries: 1. Publications: 1.
Medical and Economical Impact of IGRAs Diagnosis of Latent Tuberculosis in HIV-infected Patients
ClinicalTrials.gov study NCT00805272. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of Filarial Infection on Immune Responses in Latent Tuberculosis
ClinicalTrials.gov study NCT01547884. IPD Sharing: Not stated. Countries: 2. Publications: 3.
Prophylaxis Against Tuberculosis (TB) in Patients With Human Immunodeficiency Virus (HIV) Infection and Suspected Latent Tuberculous Infection
ClinicalTrials.gov study NCT00000959. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Enhancing the Public Health Impact of Latent Tuberculosis (TB) Infection Diagnosis and Treatment
ClinicalTrials.gov study NCT02810678. IPD Sharing: Not stated. Countries: 5. Publications: 3.
Immune Responses to Mycobacterium Tuberculosis (Mtb) in People With Latent Tuberculosis Infection With or Without Concomitant Helminth Infection
ClinicalTrials.gov study NCT02225158. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Study of Latent Tuberculosis Infection (LTBI) by High Resolution Scanner
ClinicalTrials.gov study NCT00904956. IPD Sharing: Not stated. Countries: 1. Publications: 6.
ScienceDex guides
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.