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10 results for “Leishmania braziliensis”
Leishmanicidal and healing effects of 3β,6β,16β-trihydroxy lup-20 (29)-ene isolated from Combretum leprosum on Leishmania braziliensis infection in vitro and in vivo
<p>Treatment of cutaneous leishmaniasis depends on drugs that potentially cause serious side effects and resistance. Thus, topical therapies are attractive alternatives to the drugs currently used. 3β, 6β, 16β-trihydroxylup-20 (29)-ene is a lupane triterpene isolated from Combretum leprosum Mart. leaves (CLF-1), with reports of in vitro antileishmanial effect against L. amazonensis and to promote lesion healing in animal model. Herein, we evaluated the in vitro and in vivo antileishmanial and healing effects of CLF-1 against L. braziliensis. CLF-1 treatment showed low toxicity in macrophages and significantly reduced parasite load in vitro. CLF-1 induced higher IL-12 and TNF-α production and more discrete IL-4 and IL-10 production. For in vivo evaluation, a CLF-1 cream formulation was prepared to treat hamsters infected with L. braziliensis. CLF-1 treatment was able to reduce parasite load on the infected skin and lymph node more efficiently than the conventional treatment. Histopathological analysis indicated a strong inflammatory response accompanied by an important healing response. Data from this study indicate that topical CLF-1 treatment was effective and non-toxic in L. braziliensis infected hamsters suggesting its potential for further development as a future therapeutic intervention.</p>
Pathway/Genome Database (PGDB) for Leishmania major, Leishmania infantum, Leishmania donovani, and Leishmania braziliensis
<p>This set of four metabolic reconstructions were created using Pathway Tools v. 18.0 and reported in the work "High-throughput prioritization of target proteins for development of new antileishmanial compounds" (under review). The methodology for automatic creation and curation is presented below.</p> <p> </p> <p> </p>
Transcription profiling of cutaneous lesions caused by Leishmania braziliensis and normal skin.
GEO Series GSE63931. Homo sapiens. 16 samples. Type: Expression profiling by array.
CD8 T cells induce perforin-dependent pathology in Leishmania braziliensis infection
GEO Series GSE43880. Homo sapiens. 12 samples. Type: Expression profiling by array.
Computational discovery of conserved RNA structures and functional characterization of a structured lncRNA in Leishmania braziliensis
GEO Series GSE287035. Leishmania braziliensis. 21 samples. Type: Expression profiling by high throughput sequencing.
beta-glucan-induced trained immunity protects against Leishmania braziliensis infection: a crucial role for IL-32
GEO Series GSE132155. Homo sapiens. 40 samples. Type: Expression profiling by high throughput sequencing.
Genomic profiling of human Leishmania braziliensis lesions identifies transcriptional modules associated with cutaneous immunopathology
GEO Series GSE55664. Homo sapiens. 35 samples. Type: Expression profiling by array.
Transcriptional remodeling of primary human monocytes exposed to Leishmania braziliensis
GEO Series GSE211212. Homo sapiens. 21 samples. Type: Expression profiling by high throughput sequencing.
Differential gene expression between uninfected and infected U937 derived macrophages with Leishmania braziliensis
GEO Series GSE61211. Homo sapiens. 18 samples. Type: Expression profiling by array.
Transcriptomics analysis highlights potential ways in human pathogenesis in Leishmania braziliensis infected with the viral endosymbiont LRV1
GEO Series GSE247487. Homo sapiens. 9 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.