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219 results for “Leptin”
Figure 2 in The effects of feeding obese rats with bee bread on leptin and ghrelin expression
Figure 2. Cells stained with ghrelin (A) and leptin (B) in hypothalamus tissue are shown with black arrows. A: Group 1 (fed with standard rat food), B: Group 2 (obese - fed with high-fat diet), C: Group 3 (high-fat diet and 100 mg/kg/day bee bread), D: Group 4 (high-fat diet and 200 mg/kg/day bee bread), E: Group 5 (high-fat diet and 300 mg/kg/day metformin). Image zoom 400×.
Figure 1 in The effects of feeding obese rats with bee bread on leptin and ghrelin expression
Figure 1. Cells, stained with hematoxylin and eosin in hypothalamus tissue are shown with black arrows. Image zoom 400×. A: Group 1 (fed with standard rat food), B: Group 2 (obese - fed with high-fat diet), C: Group 3 (high-fat diet and 100 mg/kg/day bee bread), D: Group 4 (high-fat diet and 200 mg/kg/day bee bread), E: Group 5 (high-fat diet and 300 mg/kg/day metformin).
Contrasting association of Leptin receptor polymorphisms and haplotypes with polycystic ovary syndrome in Bahraini and Tunisian women: a case–control study
<p><span><b>Background</b>. This study examined the contribution of ethnicity to the association of leptin receptor gene (<i>LEPR)</i> genetic variants with polycystic ovary syndrome (PCOS) in Tunisian and Bahraini Arabic-speaking women.<b> </b></span></p> <p><span><b>Methods. </b>Subjects consisted of 320 women with PCOS, and 446 eumenorrhic women from Tunisia, and 242 women with PCOS and 238 controls from Bahrain. Genotyping of (exonic) rs1137100 and rs1137101 and (intronic) rs2025804 <i>LEPR</i> variants was done by allelic exclusion.<b> </b></span></p> <p><span><b>Results. </b>The minor allele frequencies of rs1137100 and rs1137101 were significantly different between PCOS cases and control women from Bahrain but not Tunisia, and <i>LEPR</i> rs1137101 was associated with increased PCOS susceptibility only in Bahraini subjects. Furthermore, rs1137100 was associated with decreased PCOS risk among Bahrainis under codominant and recessive models; rs1137100 was negatively associated with PCOS in Tunisians after controlling for testosterone. In addition, rs2025804 was associated with increased PCOS risk among Tunisian but not Bahraini women, after adjusting for key covariates. Negative correlation was seen between rs1137101 and triglycerides in Tunisians, while HOMA-IR and insulin correlated with rs2025804 and rs1137101 among Bahraini subjects, and rs1137101 correlated with estradiol and prolactin. Taking TAG haplotype as common, positive association of TAA and negative association of TGG haplotype with PCOS was seen among Bahraini women; no three-locus PCOS-associated haplotypes were found in Tunisians.<b> </b></span></p> <p><span><b>Conclusions. </b>T<span>his study is the first to demonstrate the contribution of ethnicity to the association of <i>LEPR</i> gene variants with PCOS</span>, thereby highlighting the significance of controlling for ethnicity in gene association investigations.</span></p>
Mechanism of receptor assembly via the pleiotropic adipokine Leptin - single molecule tracking - raw data
<p>This dataset contains the raw single-molecule image data that was analyzed in the manuscript "Mechanism of receptor assembly via the pleiotropic adipokine Leptin"</p>
Leptin to Treat Lipodystrophy
ClinicalTrials.gov study NCT00025883. IPD Sharing: YES. Countries: 1. Publications: 16.
Leptin in Human Energy and Neuroendocrine Homeostasis
ClinicalTrials.gov study NCT00265980. IPD Sharing: Not stated. Countries: 1. Publications: 8.
Clinical Protocol to Investigate the Efficacy of Recombinant Human Leptin (Metreleptin) in Nonalcoholic Steatohepatitis (NASH) or Nonalcoholic Fatty Liver Disease (NAFLD) Associated With Lipodystrophy
ClinicalTrials.gov study NCT01679197. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Effects of Leptin Replacement in Children
ClinicalTrials.gov study NCT00659828. IPD Sharing: NO. Countries: 1. Publications: 13.
Effect of Increased Free Fatty Acids on Leptin Function
ClinicalTrials.gov study NCT01520454. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Salivary and Serum Leptin Levels in Oral Lichen Planus Patients: A Case-control Study.
ClinicalTrials.gov study NCT06078579. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Recombinant Human Leptin Therapy Effects on Insulin Action
ClinicalTrials.gov study NCT01207934. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Pharmacokinetics of Leptin Administration During Fasting
ClinicalTrials.gov study NCT00140205. IPD Sharing: Not stated. Countries: 1. Publications: 5.
A Study to Evaluate the Effect on Body Weight of Leptin Administered in Conjunction With Pramlintide in Overweight and Obese Subjects
ClinicalTrials.gov study NCT00392925. IPD Sharing: Not stated. Countries: 1. Publications: 1.
In Vivo Leptin Signaling in Humans After Acute Leptin Administration
ClinicalTrials.gov study NCT01275053. IPD Sharing: NO. Countries: 1. Publications: 1.
Leptin Infusion and Endothelial Vasomotor Response
ClinicalTrials.gov study NCT04374500. IPD Sharing: YES. Countries: 2. Publications: 1.
Study of Leptin for the Treatment of Hypothalamic Amenorrhea
ClinicalTrials.gov study NCT00130117. IPD Sharing: NO. Countries: 1. Publications: 11.
Randomized, Placebo-Controlled Study of Leptin for the Treatment of HIV Lipodystrophy and Metabolic Syndrome
ClinicalTrials.gov study NCT00140244. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Leptin for Abnormal Lipid Kinetics in HIV Lipodystrophy Syndrome
ClinicalTrials.gov study NCT01511016. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Setmelanotide for the Treatment of Leptin Receptor (LEPR) Deficiency Obesity
ClinicalTrials.gov study NCT03287960. IPD Sharing: NO. Countries: 6. Publications: 1.
Recombinant Leptin Therapy for Treatment of Nonalcoholic Steatohepatitis (NASH)
ClinicalTrials.gov study NCT00596934. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
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