Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
15
datasets available to search
ShareScore release 0.7.1
Dataset results
15 results for “Leptospira interrogans”
Data from: Detecting signals of chronic shedding to explain pathogen persistence: Leptospira interrogans in California sea lions
Identifying mechanisms driving pathogen persistence is a vital component of wildlife disease ecology and control. Asymptomatic, chronically infected individuals are an oft-cited potential reservoir of infection but demonstrations of the importance of chronic shedding to pathogen persistence at the population level remain scarce. Studying chronic shedding using commonly collected disease data is hampered by numerous challenges, including short-term surveillance that focuses on single epidemics and acutely ill individuals, the subtle dynamical influence of chronic shedding relative to more obvious epidemic drivers, and poor ability to differentiate between the effects of population prevalence of chronic shedding versus intensity and duration of chronic shedding in individuals. We use chronic shedding of Leptospira interrogans serovar Pomona in California sea lions (Zalophus californianus) as a case study to illustrate how these challenges can be addressed. Using leptospirosis-induced strands as a measure of disease incidence, we fit models with and without chronic shedding, and with different seasonal drivers, to determine the timescale over which chronic shedding is detectable and the interactions between chronic shedding and seasonal drivers needed to explain persistence and outbreak patterns. Chronic shedding can enable persistence of L. interrogans within the sea lion population. However, the importance of chronic shedding was only apparent when surveillance data included at least two outbreaks and the intervening inter-epidemic trough during which fadeout of transmission was most likely. Seasonal transmission, as opposed to seasonal recruitment of susceptibles, was the dominant driver of seasonality in this system, and both seasonal factors had limited impact on long-term pathogen persistence. We show that the temporal extent of surveillance data can have a dramatic impact on inferences about population processes, where the failure to identify both short- and long-term ecological drivers can have cascading impacts on understanding higher-order ecological phenomena, such as pathogen persistence.
Exprimental Data:Caspase-11 non-canonical inflammasome mediates the expression of proinflammatory cytokines in murine macrophages infected with leptospira interrogans.
<p>This is the exprimental data of manuscripts submitted in ALL LIFE magazine. The title is Caspase-11 non-canonical inflammasome mediates the expression of proinflammatory cytokines in murine macrophages infected with leptospira interrogans.)</p>
Data from: Detecting signals of chronic shedding to explain pathogen persistence: Leptospira interrogans in California sea lions
Open the record for dataset details and reuse information.
Data from crystal of Leucine-Rich Repeat Protein from Leptospira interrogans recorded during routine commissioning on Diamond Light Source beamline I04
<p>Samples as part of ongoing research / collaboration; for more details see https://www.ncbi.nlm.nih.gov/pubmed/26057675</p>
Data from: MHC class II DRB diversity predicts antigen recognition and is associated with disease severity in California sea lions naturally infected with Leptospira interrogans
Open the record for dataset details and reuse information.
Analysis of the human endothelial cell response to pathogenic Leptospira interrogans vs. non-pathogenic Leptospira biflexa (HMEC data)
GEO Series GSE23173. Homo sapiens. 18 samples. Type: Expression profiling by array.
Global LexA1 binding sites assessment in Leptospira interrogans serivar Copenhageni using ChIP-seq
GEO Series GSE73688. Leptospira interrogans serovar Copenhageni. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
A pathogen-specific 4mC methyltransferase is critical for epigenetic regulation and virulence of Leptospira interrogans
GEO Series GSE138917. Leptospira interrogans serovar Manilae. 9 samples. Type: Expression profiling by high throughput sequencing.
Analysis of the human endothelial cell response to pathogenic Leptospira interrogans vs. non-pathogenic Leptospira biflexa (Eahy1 data)
GEO Series GSE23172. Homo sapiens. 36 samples. Type: Expression profiling by array.
Global transcriptomic response of Leptospira interrogans serovar Copenhageni upon exposure to serum
GEO Series GSE17942. Leptospira interrogans. 3 samples. Type: Expression profiling by array.
Transcriptional response of Leptospira interrogans to iron limitation and characterization of putative Fur-like protein
GEO Series GSE20422. Leptospira interrogans. 6 samples. Type: Expression profiling by array.
In Vivo Dual RNA-Seq identifies a novel AB Toxin-like as a key effector of Leptospira interrogans barrier disruption (or host colonization)
GEO Series GSE295802. Mesocricetus auratus; Leptospira interrogans. 39 samples. Type: Expression profiling by high throughput sequencing.
IgG antibody profiling of Leptospira interrogans serovar Copenhageni in infected and non-infected subjects using protein microarray
GEO Series GSE42720. Homo sapiens; Leptospira interrogans serovar Copenhageni. 274 samples. Type: Protein profiling by protein array.
A Model System for Studying the Transcriptomic and Physiological Changes Associated with Mammalian Host-Adaptation by Leptospira interrogans Serovar Copenhageni
GEO Series GSE53818. Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130. 6 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide transcriptional start site mapping and sRNA identification in the pathogen Leptospira interrogans
GEO Series GSE92976. Leptospira interrogans serovar Manilae. 8 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.