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Dataset results
86 results for “Lipodystrophy”
Leptin to Treat Lipodystrophy
ClinicalTrials.gov study NCT00025883. IPD Sharing: YES. Countries: 1. Publications: 16.
Clinical Protocol to Investigate the Efficacy of Recombinant Human Leptin (Metreleptin) in Nonalcoholic Steatohepatitis (NASH) or Nonalcoholic Fatty Liver Disease (NAFLD) Associated With Lipodystrophy
ClinicalTrials.gov study NCT01679197. IPD Sharing: Not stated. Countries: 1. Publications: 2.
The BROADEN Study: A Study of Volanesorsen (Formerly IONIS-APOCIIIRx) in Participants With Familial Partial Lipodystrophy
ClinicalTrials.gov study NCT02527343. IPD Sharing: Not stated. Countries: 7. Publications: 1.
Physiologic Growth Hormone Effects in HIV Lipodystrophy
ClinicalTrials.gov study NCT00100698. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Cholic Acid for Hepatic Steatosis in Lipodystrophy
ClinicalTrials.gov study NCT00457639. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Aramchol for HIV-associated Nonalcoholic Fatty Liver Disease and Lipodystrophy
ClinicalTrials.gov study NCT02684591. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Randomized, Placebo-Controlled Study of Leptin for the Treatment of HIV Lipodystrophy and Metabolic Syndrome
ClinicalTrials.gov study NCT00140244. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Leptin for Abnormal Lipid Kinetics in HIV Lipodystrophy Syndrome
ClinicalTrials.gov study NCT01511016. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Diet, Exercise, Niacin, and Fenofibrate to Reduce Heart Disease Risk Factors in Individuals With HIV Lipodystrophy or Dyslipidemia
ClinicalTrials.gov study NCT00246376. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Short-term Effects of Leptin in People With Lipodystrophy
ClinicalTrials.gov study NCT01778556. IPD Sharing: Not stated. Countries: 1. Publications: 12.
Efficacy, Safety and Tolerability of ISIS 304801 in People With Partial Lipodystrophy With an Open-Label Extension
ClinicalTrials.gov study NCT02639286. IPD Sharing: NO. Countries: 1. Publications: 5.
TH9507 Extension Study in Patients With HIV-Associated Lipodystrophy
ClinicalTrials.gov study NCT00608023. IPD Sharing: NO. Countries: 6. Publications: 4.
Metabolomic Analysis of the Effects of Leptin Replacement Therapy in Patients with Lipodystrophy
<p>Context and Objective </p><p>Leptin treatment has dramatic clinical effects on glucose and lipid metabolism in leptin-deficient patients with lipodystrophy. Further elucidation of metabolic effects of exogenous leptin therapy will shed light on understanding leptin physiology in humans. Our objective was to utilize metabolomic profiling to examine the changes associated with administration of short-term metreleptin therapy in patients with lipodystrophy.</p> Study Design <p>We conducted a pre-post treatment study in 19 patients (75% female) with varying forms of lipodystrophy (congenital generalized lipodystrophy, n=10; acquired generalized lipodystrophy, n=1; familial partial lipodystrophy, n=8) who received daily subcutaneous metreleptin injections for a period of 16 - 23 weeks. A 3-hour oral glucose tolerance test and body composition measurements were conducted before and after the treatment period, and fasting blood samples were used for metabolomic profiling. The study outcome aimed at measuring changes in physiologically relevant metabolites pre- and post- leptin therapy.</p> Results <p>Metabolomic analysis revealed changes in pathways involving branched-chain amino acid metabolism, fatty acid oxidation, protein degradation, urea cycle, tryptophan metabolism, nucleotide catabolism, vitamin E, and steroid metabolism. Fold-changes in pre- to post-treatment metabolite levels indicated increased breakdown of fatty acids, branched chain amino acids proteins, and nucleic acids.</p> Conclusions <p>Leptin replacement therapy has significant effects on important metabolic pathways implicated in patients with lipodystrophy. Continued metabolomic studies may provide further insight into the mechanisms of action of leptin replacement therapy and provide novel biomarkers of lipodystrophy.</p> <p></p>
Adipocyte, Insulin-resistance and Immunity : Evaluation of Interleukin-7 in Lipodystrophy, Diabetes and Obesity
ClinicalTrials.gov study NCT01784289. IPD Sharing: NO. Countries: 1. Publications: 1.
Novel Therapies for Metabolic Complications of Lipodystrophies
ClinicalTrials.gov study NCT00457938. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Compassionate Use of Metreleptin in Previously Treated People With Generalized Lipodystrophy
ClinicalTrials.gov study NCT02262832. IPD Sharing: NO. Countries: 1. Publications: 3.
Low Energy Diet and Familial Partial Lipodystrophy
ClinicalTrials.gov study NCT03900286. IPD Sharing: NO. Countries: 1. Publications: 2.
Leptin to Treat Lipodystrophy
ClinicalTrials.gov study NCT00005905. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Registry for Patients With Lipodystrophy
ClinicalTrials.gov study NCT03553420. IPD Sharing: YES. Countries: 16. Publications: 1.
A Study to Determine How and Why HIV-Infected Subjects on Anti-viral Treatment Develop Lipodystrophy
ClinicalTrials.gov study NCT00006190. IPD Sharing: Not stated. Countries: 1. Publications: 6.
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