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25 results for “Liquid-liquid phase separation”
Amino Acids Modulate Liquid-Liquid Phase Separation in vitro and in vivo by Regulating Protein-Protein Interactions
<p>The metadata, plots and microscopy images for the manuscript "Amino Acids Modulate Liquid-Liquid Phase Separation in vitro and in vivo by Regulating Protein-Protein Interactions".</p>
DNA-stimulated liquid-liquid phase separation by eukaryotic topoisomerase II modulates catalytic function
<p>Type II topoisomerases modulate chromosome supercoiling, condensation, and catenation by moving one double-stranded DNA segment through a transient break in a second duplex. How DNA strands are chosen and selectively passed to yield appropriate topological outcomes – e.g., decatenation vs. catenation – is poorly understood. Here we show that at physiological enzyme concentrations, eukaryotic type IIA topoisomerases (topo IIs) readily coalesce into condensed bodies. DNA stimulates condensation and fluidizes these assemblies to impart liquid-like behavior. Condensation induces both budding yeast and human topo IIs to switch from DNA unlinking to active DNA catenation, and depends on an unstructured C-terminal region, the loss of which leads to high levels of knotting and reduced catenation. Our findings establish that local protein concentration and phase separation can regulate how topo II creates or dissolves DNA links, behaviors that can account for the varied roles of the enzyme in supporting transcription, replication, and chromosome compaction.</p>
DNA-stimulated liquid-liquid phase separation by eukaryotic topoisomerase II modulates catalytic function
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Data files for the publication "Surfactants Regulate the Mixing State of Organic-Inorganic Mixed Aerosols Undergoing Liquid-Liquid Phase Separation"
<p>Data files for the publication “Surfactants Regulate the Mixing State of Organic-Inorganic Mixed Aerosols Undergoing Liquid-Liquid Phase Separation”</p>
Uncovering intermolecular interactions driving liquid-liquid phase separation of TDP-43 low complexity domain
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PML nuclear bodies form a regulatory hub via liquid-liquid phase separation for TRIM33 control of Lefty1/2 genes in mouse embryonic stem cells [RNA-seq]
GEO Series GSE199737. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Suppression of liquid-liquid phase separation by 1,6-hexanediol partially compromises the 3D genome organization in living cells
GEO Series GSE138543. Homo sapiens. 22 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Other.
ATRX Condensates Formed by Liquid-Liquid Phase Separation Regulate Neural Progenitor Cell Identity (RNA)
GEO Series GSE276834. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
HSD17B13 liquid-liquid phase separation activates autocrine platelet-activating factor signaling in NASH
GEO Series GSE238060. Mus musculus; Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
ATRX Condensates Formed by Liquid-Liquid Phase Separation Regulate Neural Progenitor Cell Identity
GEO Series GSE276836. Homo sapiens. 30 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Deacetylation of HP1g enhances multiple myeloma drug resistance through DNA damage repair and liquid-liquid phase separation (RNA-Seq)
GEO Series GSE176546. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Bacterial Heterochromatin Formation Through Liquid-Liquid Phase Separation
GEO Series GSE174575. Escherichia coli. 36 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
To profile the chromatin structural changes reprogrammed by the liquid-liquid phase separation of DAXX [HiChIP]
GEO Series GSE223258. Homo sapiens. 3 samples. Type: Other.
Liquid-liquid phase separation of ZHX2 protects DLBCL cells against ferroptosis through induction of SLC3A2 [RNA-seq]
GEO Series GSE292498. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Homodimer-mediated phosphorylation of C/EBPα-p42 S16 modulates acute myeloid leukaemia differentiation through liquid-liquid phase separation [RNA-seq]
GEO Series GSE243422. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Homodimer-mediated phosphorylation of C/EBPα-p42 S16 modulates acute myeloid leukaemia differentiation through liquid-liquid phase separation [ChIP-seq]
GEO Series GSE243423. Homo sapiens. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Deacetylation of HP1g enhances multiple myeloma drug resistance through DNA damage repair and liquid-liquid phase separation (ChIP-seq)
GEO Series GSE218772. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Liquid-liquid phase separation of ZHX2 protects DLBCL cells against ferroptosis through induction of SLC3A2
GEO Series GSE292652. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Deacetylation of HP1g enhances multiple myeloma drug resistance through DNA damage repair and liquid-liquid phase separation (ATAC-Seq)
GEO Series GSE176545. Homo sapiens. 8 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Deacetylation of HP1g enhances multiple myeloma drug resistance through DNA damage repair and liquid-liquid phase separation
GEO Series GSE176547. Homo sapiens. 14 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
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The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
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OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.