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6 results for “Litomosoides sigmodontis”
Data from: Repeated sensitization of mice with microfilariae of Litomosoides sigmodontis induces pulmonary eosinophilia in an IL-33-dependent manner
<p><strong>Background:</strong> Eosinophilia is a hallmark of helminth infections and eosinophils are essential in the protective immune responses against helminths. Nevertheless, the distinct role of eosinophils during parasitic filarial infection, allergy and autoimmune disease-driven pathology is still not sufficiently understood. In this study, we established a mouse model for microfilariae-induced eosinophilic lung disease (ELD), a manifestation caused by eosinophil hyper-responsiveness within the lung.</p> <p><strong>Methods:</strong> Wild-type (WT) BALB/c mice were sensitized with dead microfilariae (MF) of the rodent filarial nematode <em>Litomosoides sigmodontis </em>three times at weekly intervals and subsequently challenged with viable MF to induce ELD. The resulting immune response was compared to non-sensitized WT mice as well as sensitized eosinophil-deficient dblGATA mice using flow cytometry, lung histology and ELISA. Additionally, the impact of IL-33 signaling on ELD development was investigated using the IL-33 antagonist HpARI2.</p> <p><strong>Results:</strong> ELD-induced WT mice displayed an increased type 2 immune response in the lung with increased frequencies of eosinophils, alternatively activated macrophages and group 2 innate lymphoid cells, as well as higher peripheral blood IgE, IL-5 and IL-33 levels in comparison to mice challenged only with viable MF or PBS. ELD mice had an increased MF retention in lung tissue, which was in line with an enhanced MF clearance from peripheral blood. Using eosinophil-deficient dblGATA mice we demonstrate that eosinophils are essentially involved in driving the type 2 immune response and retention of MF in the lung of ELD mice. Furthermore, we demonstrate that IL-33 drives eosinophil activation <em>in vitro</em> and inhibition of IL-33 signaling during ELD induction reduces pulmonary type 2 immune responses, eosinophil activation and alleviates lung lacunarity.</p> <p>In conclusion, we demonstrate that IL-33 signaling is essentially involved in MF-induced ELD development.</p>
Data from: Repeated sensitization of mice with microfilariae of Litomosoides sigmodontis induces pulmonary eosinophilia in an IL-33-dependent manner
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Comparative analysis of small RNAs released by the filarial nematode Litomosoides sigmodontis in vitro and in vivo
GEO Series GSE140538. Meriones unguiculatus; Litomosoides sigmodontis. 78 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Tetracycline-treated Litomosoides sigmodontis vs. untreated control Litomosoides sigmodontis
GEO Series GSE20976. Wolbachia endosymbiont strain TRS of Brugia malayi; Wuchereria bancrofti; Brugia malayi; Onchocerca volvulus; Litomosoides sigmodontis. 6 samples. Type: Expression profiling by array.
Exosomes secreted by a nematode parasite transfer small RNAs to mammalian cells and regulate genes of the innate immune system [Litomosoides sigmodontis]
GEO Series GSE60021. Litomosoides sigmodontis. 2 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Expression data from CD4+IL-4gfp+ Th2 cells isolated from BALB/c IL-4gfp 4get mice infected with the filarial nematode Litomosoides sigmodontis.
GEO Series GSE114308. Mus musculus. 27 samples. Type: Expression profiling by array.
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