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Dataset results
1,391 results for “Liver cancer”
Spatially Resolved Transcriptomics Deconvolutes Prognostic Histological Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases
<p>Spatial transcriptomic data (counts.csv) derived using the Nanostring GeoMx digital spatial profiler platform to analyse matched colonic primary and liver metastases from 4 patients with metastatic colorectal cancer. 48 AOIs of cancer transcriptome atlas data. Normalised using Q3 normalisation. In addition, normalised data (Counts - ncounter.csv) from ncounter bulk experiment comparing matched colonic primary and liver metastases</p>
Data for: Molecular mechanisms behind safranal's toxicity to liver cancer cells from dual omics
<p>The spice saffron (<em>Crocus sativus</em>) has anticancer activity in several human tissues, but the molecular mechanisms underlying potential therapeutic effects are poorly understood. We investigated the impact of safranal, a small molecule secondary metabolite from saffron, on the HCC cell line HEP-G2 using untargeted metabolomics (HPLC-MS) and transcriptomics (RNAseq). Increases in glutathione disulfide and other biomarkers for oxidative damage contrasted with lower levels of the antioxidants biliverdin IX (139-fold decrease, p=5.3E-5), the ubiquinol precursor 3-4-dihydroxy-5-all-trans-decaprenylbenzoate (3-fold decrease, p=1.9E-5), and resolvin E1 (-3,282-fold decrease, p=4E-5), which indicates sensitization to reactive oxygen species. We observed a significant increase in intracellular hypoxanthine (538-fold increase, p=7.7E-6) that may be primarily responsible for oxidative damage in HCC after safranal treatment. The accumulation of free fatty acids and other biomarkers, such as S-methyl-5'-thioadenosine, are consistent with safranal-induced mitochondrial de-uncoupling and explain the sharp increase in hypoxanthine we observed. Overall, the dual omics datasets describe routes to widespread protein destabilization and DNA damage from safranal-induced oxidative stress in HCC cells.</p>
Differential interference contrast (DIC) image of unstained living HepG2 human liver cancer cells
<p><strong>Introduction</strong></p> <p>This dataset is associated with our submission to Computers in Biology and Medicine, titled "Accurate Detection and Instance Segmentation of Unstained Living Adherent Cells in Differential Interference Contrast Images". The submission number for this manuscript is CIBM-D-23-09623R1.</p> <p><strong>Authors</strong>: Fei Pan, Yutong Wu, Kangning Cui, Shuxun Chen, Yanfang Li, Yaofang Liu, Adnan Shakoor, Han Zhao, Beijia Lu, Shaohua Zhi, Raymond Hon-Fu Chan, Dong Sun</p> <p><strong>Dataset Description</strong></p> <p>Our dataset comprises 520 differential interference contrast (DIC) images of 12,198 unstained HepG2 human liver cancer cells, each with a corresponding fluorescence image stained with calcein acetoxymethyl (AM), ensuring high-quality ground-truth annotations. Unique in addressing the multi-state nature of adherent cells commonly seen in wet labs, it includes both healthy and unhealthy cells in a single image, providing a valuable resource for studying multi-state cell detection and instance segmentation.<br>Citation</p> <p>We kindly request that researchers who use this dataset cite both our paper and this dataset. This will help acknowledge the work and facilitate further advancements in the field.</p> <p><br><strong>Please cite as follows:</strong></p> <p><strong>Paper:</strong><br>Pan, F., Wu, Y., Cui, K., Chen, S., Li, Y., Liu, Y., Shakoor, A., Zhao, H., Lu, B., Zhi, S., Chan, R. H.-F., & Sun, D. "Accurate detection and instance segmentation of unstained living adherent cells in differential interference contrast images,” <em>Computers in Biology and Medicine</em>, vol. 182, p. 109151, Nov. 2024, doi: 10/g5p9d8.</p> <p><strong>Dataset:</strong><br>Pan, F., Chen, S., Li, Y., Shakoor, A., Zhao, H., & Sun, D. (2024). Differential interference contrast (DIC) image of unstained living HepG2 human liver cancer cells. Zenodo. </p> <p>Thank you for your interest and support in our work. We look forward to seeing the innovative research that this dataset will enable.</p> <p> </p> <p> </p>
Figure 2 in Explore the antiproliferative phytocompounds from ethanolic extracts of Citrus paradisi against liver cancer cell line by chemical analysis using TLC and FT-IR spectroscopy
Figure 2. Anti-proliferative activity of ethanolic Citrus paradisi leaves extract.
Figure 3 in Explore the antiproliferative phytocompounds from ethanolic extracts of Citrus paradisi against liver cancer cell line by chemical analysis using TLC and FT-IR spectroscopy
Figure 3. FTIR analysis of ethanolic Citrus paradisi fruits extract.
Figure 1 in Explore the antiproliferative phytocompounds from ethanolic extracts of Citrus paradisi against liver cancer cell line by chemical analysis using TLC and FT-IR spectroscopy
Figure 1. Anti-proliferative activity of ethanolic Citrus paradisi fruit extract.
Hepatocellular carcinoma (HCC) Tumor microenvironment is more suppressive than colorectal cancer liver metastasis (CRLM) Tumor microenvironment.
<p><strong>Background and purpose:</strong> While HCC is an inflammation-associated cancer, CRLM develop on permissive healthy liver microenvironment. To evaluate the immune aspects of these two different environments, peripheral blood-(PB), peritumoral-(PT) and tumoral tissues-(TT) from HCC and CRLM patients were evaluated.</p> <p><strong>Methods:</strong> 40 HCC and 34 CRLM were enrolled and freshly TT, PT and PB were collected at the surgery. PB-, PT- and TT-derived CD4<sup>+</sup>CD25<sup>+ </sup>Tregs, M/PMN-MDSC and PB-derived CD4<sup>+</sup>CD25<sup>− </sup>Teffector cells (Teffs) were isolated and characterized. Tregs function was also evaluated in the presence of the CXCR4 inhibitor, Peptide-R29, AMD3100 or anti-PD1. RNA was extracted from PB/PT/TT-tissues and tested for FOXP3, CXCL12, CXCR4, CCL5, IL-15, CXCL5, Arg-1, N-cad, Vim, CXCL8, TGFβ and VEGF-A expression.</p> <p><strong>Results:</strong> In HCC/CRLM-PB higher number of functional Tregs, CD4<sup>+</sup>CD25<sup>hi</sup>FOXP3<sup>+</sup> were detected, although PB-HCC Tregs exert a more suppressive function as compared to CRLM-Tregs. In HCC/CRLM-TT Tregs were highly represented with Activated/ENTPD-1<sup>+</sup>Tregs prevalent in HCC. As compared to CRLM, HCC overexpressed CXCR4 and N-cadherin/Vimentin in a contest rich of arginase and CCL5. Monocytic-MDSCs were highly represented in HCC/CRLM while high Polymorphonuclear-MDSCs were detected only in HCC. Interestingly, CXCR4-PB-Tregs function was impaired in HCC/CRLM by the CXCR4 inhibitor R29.</p> <p><strong>Conclusion:</strong> In HCC and CRLM, peripheral blood, peritumoral and tumoral tissues-Tregs are highly represented and functional. Nevertheless, HCC display a more immunosuppressive TME due to Tregs, MDSCs, intrinsic tumor features (CXCR4, CCL5, arginase) and the contest in which it develops. As CXCR4 is overexpressed in HCC/CRLM tumor/TME cells, CXCR4 inhibitors may be considered for double hits therapy in liver cancer patients.</p>
Chemoembolization Versus Radioembolization in Treating Patients With Liver Cancer That Cannot Be Treated With Radiofrequency Ablation Or Surgery
ClinicalTrials.gov study NCT00956930. IPD Sharing: NO. Countries: 1. Publications: 1.
A Clinical Research Study to Determine Whether PD 0332991 May Be Effective in Treating Patients With Liver Cancer
ClinicalTrials.gov study NCT01356628. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Study of BO-112 With Pembrolizumab for Colorectal or Gastric/GEJ Cancer With Liver Metastasis
ClinicalTrials.gov study NCT04508140. IPD Sharing: NO. Countries: 3. Publications: 1.
BMS-986156, Ipilimumab, and Nivolumab With or Without Stereotactic Body Radiation Therapy in Treating Patients With Advanced or Metastatic Lung/Chest or Liver Cancers
ClinicalTrials.gov study NCT04021043. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety & Efficacy of NV1020 in Colorectal Cancer Metastatic to the Liver
ClinicalTrials.gov study NCT00149396. IPD Sharing: NO. Countries: 1. Publications: 1.
A Study of Vitamin C in the Treatment of Liver Cancer to Determine if it is Safe and Effective
ClinicalTrials.gov study NCT01754987. IPD Sharing: NO. Countries: 1. Publications: 1.
Pre- and Post-operative FOLFOX Based Therapy for Patients With Colorectal Cancer With Liver Involvement
ClinicalTrials.gov study NCT00537823. IPD Sharing: Not stated. Countries: 1. Publications: 30.
Chemoembolization and Bevacizumab in Treating Patients With Liver Cancer That Cannot Be Removed With Surgery
ClinicalTrials.gov study NCT00049322. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Tivozanib in Treating Patients With Liver Cancer That Is Metastatic or Cannot Be Removed by Surgery
ClinicalTrials.gov study NCT01835223. IPD Sharing: Not stated. Countries: 1. Publications: 4.
ABT-888 and Temozolomide for Liver Cancer
ClinicalTrials.gov study NCT01205828. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study Of Sunitinib Malate Versus Sorafenib In Patients With Inoperable Liver Cancer
ClinicalTrials.gov study NCT00699374. IPD Sharing: Not stated. Countries: 23. Publications: 3.
Doxorubicin and Bortezomib in Treating Patients With Liver Cancer
ClinicalTrials.gov study NCT00083226. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Phase 2b Study of Modified Vaccinia Virus to Treat Patients Advanced Liver Cancer Who Failed Sorafenib
ClinicalTrials.gov study NCT01387555. IPD Sharing: Not stated. Countries: 7. Publications: 1.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.