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313 results for “Liver resection”
Raw Data for the article: Clinical and Molecular-Based Approach in the Evaluation of Hepatocellular Carcinoma Recurrence after Radical Liver Resection
<p><strong>Background: </strong>Hepatic resection remains the treatment of choice for patients with early-stage HCC with preserved liver function. Unfortunately, however, the majority of patients develop tumor recurrence. While several clinical factors were found to be associated with tumor recurrence, HCC pathogenesis is a complex process of accumulation of somatic genomic alterations, which leads to a huge molecular heterogeneity that has not been completely understood. The aim of this study is to complement potentially predictive clinical and pathological factors with next-generation sequencing genomic profiling and loss of heterozygosity analysis.</p> <p><strong>Methods: </strong>124 HCC patients, who underwent a primary hepatic resection from January 2016 to December 2019, were recruited for this study. Next-generation sequencing (NGS) analysis and allelic imbalance assessment in a case-control subgroup analysis were performed. A time-to-recurrence analysis was performed as well by means of Kaplan-Meier estimators.</p> <p><strong>Results: </strong>Cumulative number of HCC recurrences were 26 (21%) and 32 (26%), respectively, one and two years after surgery. Kaplan-Meier estimates for the probability of recurrence amounted to 37% (95% C.I.: 24-47) and to 51% (95% C.I.: 35-62), after one and two years, respectively. Multivariable analysis identified as independent predictors of HCC recurrence: hepatitis C virus (HCV) infection (HR: 1.96, 95%C.I.: 0.91-4.24, <em>p</em> = 0.085), serum bilirubin levels (HR: 5.32, 95%C.I.: 2.07-13.69, <em>p</em> = 0.001), number of nodules (HR: 1.63, 95%C.I.: 1.12-2.38, <em>p</em> = 0.011) and size of the larger nodule (HR: 1.11, 95%C.I.: 1.03-1.18, <em>p</em> = 0.004). Time-to-recurrence analysis showed that loss of heterozygosity in the <em>PTEN</em> loci (involved in the PI3K/AKT/mTOR signaling pathway) was significantly associated with a lower risk of HCC recurrence (HR: 0.35, 95%C.I.: 0.13-0.93, <em>p</em> = 0.036).</p> <p><strong>Conclusions: </strong>multiple alterations of cancer genes are associated with HCC progression. In particular, the evidence of a specific AI mutation presented in 20 patients seemed to have a protective effect on the risk of HCC recurrence.</p>
Raw data for the article: A commentary on "Simultaneous versus staged resection for synchronous colorectal liver metastases: A population-based cohort study". Importance of avoiding any other additional risk in selected patients with synchronous colorectal liver metastases
<p>We read with great interest the article of Dr. Bogach and Colleagues, in which they have evaluated trends of resection for synchronous colorectal cancer liver metastases (CRLM) and associated patient outcomes with a retrospective cohort study from 2006 to 2015 in the province of Ontario, Canada.</p>
Raw Data for the article: Risk factors for bile leakage after liver resection for neoplastic disease
<p>Biliary leakage (BL) remains the most frequent and feared complication after hepatoresective surgery. Placement of the abdominal drainage at the end of liver surgery remains controversial due to the delicate balance between risks and potential benefits in case of BL. The study was aimed to detect possible risk factors for BL occurrence after liver surgery. We enrolled all oncologic patients who underwent liver resection from June 2016 to March 2021. BL was diagnosed according to the ISGLS definition. We have examined demographic characteristics of the patients, type of neoplasia, presence of cirrhosis, neoadjuvant chemotherapy and type of intervention. Uni- and multivariable analyses were performed to assess the predictive value of potential predictor of BL. A total of 379 patients were enrolled in the study, 16 (4.2%) of which developed BL. Among others, at univariate analysis the occurrence of BL was found to be associated with bilio-digestive anastomosis (OR: 9.75, C.I. 2.7-34.7, p < 0.001) and neoadjuvant chemotherapy (OR: 0.09, C.I 0.01,-0.88, p = 0.039). Multivariable analysis selected the body mass index (OR: 1.21, 95%C.I.: 1.04-1.41, p = 0.015), anatomical resection (OR: 8.35, 95% C.I.: 2.01-34.74, p = 0.004), and blood loss (OR: 1.09, 95%C.I.: 1.05-1.13, p < 0.001). Identification of patients at greater risk of BL can help in the choice of positioning the drainage at the end of liver surgery.</p>
Lumped parameter liver simulation to predict acute hemodynamic alterations following partial resections (simulation data)
<p>This repository contains MATLAB .mat files containing simulation data reported in the manuscript "Lumped parameter liver simulation to predict acute hemodynamic alterations following partial resections" by Jeffrey Tithof, Timothy L. Pruett, and Joseph Sushil Rao (University of Minnesota). See the README file for details of which data set corresponds to which figure.</p>
Clinical Trial of Standard Versus Goal-Directed Perioperative Fluid Management (GDT) for Patients Undergoing Liver Resection
ClinicalTrials.gov study NCT01596283. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Perioperative Outcomes of Simultaneous Colorectal and Liver Resections
ClinicalTrials.gov study NCT05475041. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Nivolumab With or Without Ipilimumab in Treating Patients With Resectable Liver Cancer
ClinicalTrials.gov study NCT03222076. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Vandetanib-eluting Radiopaque Embolic Beads in Patients With Resectable Liver Malignancies
ClinicalTrials.gov study NCT03291379. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Safety and Bioactivity of Ipilimumab and Nivolumab Combination Prior to Liver Resection in Hepatocellular Carcinoma
ClinicalTrials.gov study NCT03682276. IPD Sharing: NO. Countries: 1. Publications: 1.
PET/CT in Diagnosing Patients With Liver Cancer Undergoing Surgical Resection
ClinicalTrials.gov study NCT01395030. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of Human Plasma Protein Transfusion With and Without Crystalloids During Major Liver Resection Surgeries
ClinicalTrials.gov study NCT05033704. IPD Sharing: YES. Countries: 1. Publications: 12.
Preoperative High Dose Steroids for Liver Resection- Effect on Complications in the Immediate Postoperative Period
ClinicalTrials.gov study NCT03403517. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Usefulness of BiClamp Forceps for Liver Resection: A Randomized Clinical Trial
ClinicalTrials.gov study NCT02197481. IPD Sharing: UNDECIDED. Countries: 1. Publications: 4.
Oslo Randomized Laparoscopic Versus Open Liver Resection for Colorectal Metastases Study
ClinicalTrials.gov study NCT01516710. IPD Sharing: YES. Countries: 1. Publications: 3.
Data from: Is strain elastography (IO-SE) sufficient for characterization of liver lesions before surgical resection - or is contrast enhanced ultrasound (CEUS) necessary?
Aim: To evaluate the diagnostic accuracy of IO-SE in comparison to IO-CEUS for the differentiation between malignant and benign liver lesions. Material and Methods: In a retrospective diagnostic study IO-CEUS and SE examinations of 49 liver lesions were evaluated and compared to histopathological examinations. Ultrasound was performed using a multifrequency linear probe (6–9 MHz). The loops of CEUS were evaluated up to 5 min. The qualitative characterization of IO-SE was based on a color coding system (blue = hard, red = soft). Stiffness of all lesions was quantified by a specific scaling of 0–6 (0 = low, 6 = high) using 7 ROIs (2 central, 5 peripheral). Results: All malignant lesions displayed a characteristic portal venous washout and could be diagnosed correctly by IO-CEUS. 3/5 benign lesions could not be characterized properly either by IO-CEUS or IO-SE prior to resection. Thus for IO-CEUS sensitivity, specificity, positive and negative predictive value and accuracy were 100%, 40%, 94%, 100% and 94%. Lesion sizes were between 8 and 59 mm in diameter. Regarding the IO-SE, malignant lesions showed a marked variability. In qualitative analysis, 31 of the malignant lesions were blue colored denoting overall induration. Thirteen malignant lesions showed an inhomogenous color pattern with partial indurations. Two of the benign lesions also displayed overall induration. The other benign lesions showed an inhomogenous color mapping. Calculated sensitivity of the SE was 70.5%, specificity 60%, PPV 94%, NPV 18.75%, and accuracy 69%. Conclusion: IO-CEUS is useful for localization and characterization of liver lesions prior to surgical resection whereas IO-SE provided correct characterization only for a limited number of lesions.
EOB-MR Based Radiomics Analysis to Assess Clinical Outcomes Following Liver Resection in Colorectal Liver Metastases
<p>I uploaded the images of the manuscript " EOB-MR Based Radiomics Analysis to Assess Clinical Outcomes Following Liver Resection in Colorectal Liver Metastases" accepted on Cancers Journal.</p>
CT-Based Radiomics Analysis to predict histo-pathological outcomes following liver resection in Colorectal Liver Metastases
<p>I uploaded the images of the manuscript "CT-Based Radiomics Analysis to predict histo-pathological outcomes following liver resection in Colorectal Liver Metastases".</p> <p>The objective of the study was to assess the radiomics features obtained by computed tomography (CT) examination as prognostic biomarkers in patients with liver colon rectal metastases in order to predict histo-pathological outcomes following liver resection. We demonstrated a good performance considering the single textural significant metric in the identification of front of tumor growth (expansive versus infiltrative) and tumor budding (high grade versus low grade or absent), in the recognition of mucinous type and in the detection of recurrences.</p>
Radiomics Textural Features by MR Imaging to assess clinical outcomes following liver resection in Colorectal Liver Metastases
<p>I uploaded the images od the manuscript "Radiomics Textural Features by MR Imaging to assess clinical outcomes following liver resection in Colorectal Liver Metastases"</p>
Robotic extrahepatic Glissonean pedicle isolation focusing on Laennec's capsule for anatomic liver resection: short-term surgical outcomes
<p>We will submit an article for publication in the <em>Journal of Personalized Medicine, </em>titled <strong>“</strong><strong>Robotic extrahepatic Glissonean pedicle isolation focusing on Laennec's capsule for anatomic liver resection: short-term surgical outcomes</strong><strong>” </strong></p> <p>This article describes the utility of the Glissonean pedicle isolation as an Inflow control in anatomic liver resection. We examined Laennec's capsule surrounding the Glissonean pedicle. Furthermore, we found that the use of a recently developed surgical robotic system may reduce the difficulty and improve the safety of the procedure. These files are video clips of Glissonan pedicle isolation in laparoscopic and robotic surgery.</p> <p><strong>Supplementary file 1.</strong> Laparoscopic extrahepatic left Glissonean pedicle isolation in cadaveric models.</p> <p><strong>Supplementary file 2.</strong> Laparoscopic extrahepatic right anterior and posterior Glissonean pedicle isolation. </p> <p><strong>Supplementary file 3.</strong> Laparoscopic extrahepatic Glissonean pedicle 8 isolation.</p> <p><strong>Supplementary file 4.</strong> Robotic extrahepatic right posterior Glissonean pedicle isolation.</p> <p><strong>Supplementary file 5.</strong> Robotic extrahepatic Glissonean pedicle 4a, 4b, and 4c isolation.</p>
Neoadjuvant Dupilumab and Toripalimab in MSS CRC Subjects With Resectable Liver Metastases
ClinicalTrials.gov study NCT07277322. IPD Sharing: NO. Countries: 1. Publications: 8.
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