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ShareScore release 0.9.0
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6 results for “Longshanks”
Data from: An integrative genomic analysis of the Longshanks selection experiment for longer limbs in mice
Evolutionary studies are often limited by missing data that are critical to understanding the history of selection. Selection experiments, which reproduce rapid evolution under controlled conditions, are excellent tools to study how genomes evolve under selection. Here we present a genomic dissection of the Longshanks selection experiment, in which mice were selectively bred over 20 generations for longer tibiae relative to body mass, resulting in 13% longer tibiae in two replicates. We synthesized evolutionary theory, genome sequences and molecular genetics to understand the selection response and found that it involved both polygenic adaptation and discrete loci of major effect, with the strongest loci tending to be selected in parallel between replicates. We show that selection may favor de-repression of bone growth through inactivating two limb enhancers of an inhibitor, Nkx3-2. Our integrative genomic analyses thus show that it is possible to connect individual base-pair changes to the overall selection response.
Data from: An integrative genomic analysis of the Longshanks selection experiment for longer limbs in mice
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Comparative transcriptomic analysis of the proximal tibial growth plates of 14-day old Longshanks and wildtype mice
GEO Series GSE189528. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
An integrative genomic analysis of the Longshanks selection experiment for longer limbs in mice
GEO Series GSE121566. Mus musculus. 30 samples. Type: Other; Genome binding/occupancy profiling by high throughput sequencing.
An integrative genomic analysis of the Longshanks selection experiment for longer limbs in mice (4C-seq)
GEO Series GSE121564. Mus musculus. 27 samples. Type: Other.
An integrative genomic analysis of the Longshanks selection experiment for longer limbs in mice (ATAC-seq)
GEO Series GSE121565. Mus musculus. 3 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
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Allen Brain Atlas
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.