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138 results for “Low Grade Glioma”
Return to work following diagnosis of low-grade glioma: A nationwide matched cohort study
<p>Objective: Return-to-work (RTW) following diagnosis of infiltrative low-grade gliomas (LGG) is unknown. </p> <p>Methods: Swedish patients with histopathological verified WHO grade II diffuse glioma diagnosed between 2005-2015 were included. Data were acquired from several Swedish registries. A total of 381 patients aged 18-60 were eligible. A matched control population (n=1900) was acquired. Individual data on sick leave, compensations, comorbidity, and treatments assigned were assessed. Predictors were explored using multivariable logistic regression. </p> <p>Results: One year before surgery/index date, 88 % of cases were working compared to 91 % of controls. The proportion of controls working remained constant, while patients had a rapid increase in sick leave approximately six months prior to surgery. After one and two years respectively, 52 % and 63 % of the patients were working. Predictors for no-RTW after one year were previous sick leave (OR 0.92, 95 % CI 0.88-0.96, p <0.001), older age (OR 0.96, 95 % CI 0.94-0.99, p=0.005) and lower functional level (OR 0.64 95% CI, 0.45-0.91 p=0.01). Patients receiving adjuvant treatment were less likely to RTW within the first year. At two years, biopsy (as opposed to resection), female sex and co-morbidity were also unfavorable, while age and adjuvant treatment were no longer significant. </p> <p>Conclusions: Approximately half of the patients RTW within the first year. Lower functional status, previous sick leave, older age, and adjuvant treatment were risk factors for no-RTW at one year after surgery. Female sex, co-morbidity, and biopsy only were also unfavorable for RTW at two years.</p>
PNOC 001: Phase II Study of Everolimus for Recurrent or Progressive Low-grade Gliomas in Children
ClinicalTrials.gov study NCT01734512. IPD Sharing: NO. Countries: 1. Publications: 1.
Carboplatin, Vincristine, and Temozolomide in Treating Children With Progressive and/or Symptomatic Low-Grade Glioma
ClinicalTrials.gov study NCT00077207. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Bevacizumab and Irinotecan in Treating Young Patients With Recurrent, Progressive, or Refractory Glioma, Medulloblastoma, Ependymoma, or Low Grade Glioma
ClinicalTrials.gov study NCT00381797. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study of Varlilumab and IMA950 Vaccine Plus Poly-ICLC in Patients With WHO Grade II Low-Grade Glioma (LGG)
ClinicalTrials.gov study NCT02924038. IPD Sharing: NO. Countries: 1. Publications: 1.
A Trial of Poly-ICLC in the Management of Recurrent Pediatric Low Grade Gliomas
ClinicalTrials.gov study NCT01188096. IPD Sharing: NO. Countries: 1. Publications: 0.
Return to work following diagnosis of low-grade glioma: A nationwide matched cohort study
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Feasibility of Individualized, Model-guided Optimization of Proton Beam Treatment Planning in Patients With Low Grade Glioma
ClinicalTrials.gov study NCT05964569. IPD Sharing: NO. Countries: 1. Publications: 0.
Registry Study on Epidemiological and Biological Disease Profile as Well as Clinical Outcome in Patients With Low Grade Gliomas
ClinicalTrials.gov study NCT02686229. IPD Sharing: NO. Countries: 1. Publications: 1.
Proton Beam Radiation Therapy in Treating Patients With Low Grade Gliomas
ClinicalTrials.gov study NCT01024907. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Vinblastine and Carboplatin in Treating Young Patients With Newly Diagnosed or Recurrent Low-Grade Glioma
ClinicalTrials.gov study NCT00352495. IPD Sharing: Not stated. Countries: 2. Publications: 1.
A Study Comparing Two Carboplatin Containing Regimens for Children and Young Adults With Previously Untreated Low Grade Glioma
ClinicalTrials.gov study NCT02455245. IPD Sharing: Not stated. Countries: 1. Publications: 18.
Fluorescence-guided Surgery for Low- and High-grade Gliomas
ClinicalTrials.gov study NCT01502280. IPD Sharing: Not stated. Countries: 1. Publications: 1.
FG001 in Subjects with Meningiomas or Presumed Low-Grade Gliomas Scheduled for Neurosurgery
ClinicalTrials.gov study NCT06684795. IPD Sharing: NO. Countries: 1. Publications: 2.
A Study of the Drugs Selumetinib Versus Carboplatin/Vincristine in Patients With Neurofibromatosis and Low-Grade Glioma
ClinicalTrials.gov study NCT03871257. IPD Sharing: YES. Countries: 3. Publications: 1.
A Study to Evaluate Tovorafenib in Pediatric and Young Adult Participants With Relapsed or Progressive Low-Grade Glioma and Advance Solid Tumors
ClinicalTrials.gov study NCT04775485. IPD Sharing: Not stated. Countries: 11. Publications: 1.
Weekly Vinblastine for Chemotherapy Naive Children With Progressive Low Grade Glioma (PLGGs)
ClinicalTrials.gov study NCT00575796. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study of AB-218 in Patients With IDH1 Mutated Low Grade Glioma
ClinicalTrials.gov study NCT05577416. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Selumetinib in Treating Young Patients With Recurrent or Refractory Low Grade Glioma
ClinicalTrials.gov study NCT01089101. IPD Sharing: Not stated. Countries: 1. Publications: 1.
DAY101 vs. Standard of Care Chemotherapy in Pediatric Participants With Low-Grade Glioma Requiring First-Line Systemic Therapy (LOGGIC/FIREFLY-2)
ClinicalTrials.gov study NCT05566795. IPD Sharing: NO. Countries: 30. Publications: 1.
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