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522 results for “Lung function”
Function of RORA in mouse lung inflammation
<p>This dataset contains microscopy images of mice lung, RORA KO vs wildtype. The mice were infected with N. brasiliensis.</p>
The Effect of Dupilumab on Lung Inflammation and Related Changes in Airway Volumes Detectable by Functional Respiratory Imaging in Patients With Moderate-severe Asthma
ClinicalTrials.gov study NCT04400318. IPD Sharing: YES. Countries: 13. Publications: 2.
Efficacy Regarding Renal Function of Everolimus in Combination With Specific Standard Immunosuppressive Regimen Lung Transplant Recipients
ClinicalTrials.gov study NCT01404325. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Data from: Integrative genomic analysis in African American children with asthma finds 3 novel loci associated with lung function
<p>Bronchodilator drugs are commonly prescribed for treatment and management of obstructive lung function present with diseases such as asthma. Administration of bronchodilator medication can partially or fully restore lung function as measured by pulmonary function tests. The genetics of baseline lung function measures taken prior to bronchodilator medication has been extensively studied, and the genetics of the bronchodilator response itself has received some attention. However, few studies have focused on the genetics of post-bronchodilator lung function. To address this gap, we analyzed lung function phenotypes in 1,103 subjects from the Study of African Americans, Asthma, Genes, and Environment (SAGE), a pediatric asthma case-control cohort, using an integrative genomic analysis approach that combined genotype, locus-specific genetic ancestry, and functional annotation information. We integrated genome-wide association study (GWAS) results with an admixture mapping scan of three pulmonary function tests (FEV1, FVC, and FEV1/FVC) taken before and after albuterol bronchodilator administration on the same subjects, yielding six traits. We identified 18 GWAS loci, and 5 additional loci from admixture mapping, spanning several known and novel lung function candidate genes. Most loci identified via admixture mapping exhibited wide variation in minor allele frequency across genotyped global populations. Functional fine-mapping revealed an enrichment of epigenetic annotations from peripheral blood mononuclear cells, fetal lung tissue, and lung fibroblasts. Our results point to three novel potential genetic drivers of pre- and post-bronchodilator lung function: ADAMTS1, RAD54B, and EGLN3. </p>
Vitamin C to Decrease Effects of Smoking in Pregnancy on Infant Lung Function
ClinicalTrials.gov study NCT01723696. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Evaluation of Lung Function and Symptoms in Patients Diagnosed With Chronic Obstructive Pulmonary Disease (COPD) on Long-Acting Bronchodilator Monotherapy
ClinicalTrials.gov study NCT00791518. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Feasibility Study Incorporating Lung Function Imaging Into Radiation Therapy for Lung Cancer Patients
ClinicalTrials.gov study NCT02528942. IPD Sharing: NO. Countries: 1. Publications: 2.
Effect of Roflumilast on Lung Function in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Salmeterol: The EOS Study (BY217/M2-127)
ClinicalTrials.gov study NCT00313209. IPD Sharing: Not stated. Countries: 10. Publications: 2.
Effect of a Daily Text Reminder on Asthma Medication Use, Symptom Control, and Lung Function in Children
ClinicalTrials.gov study NCT07053839. IPD Sharing: NO. Countries: 1. Publications: 5.
Study to Assess Efficacy and Safety of PT009 Compared to PT005, PT008, and Symbicort® Turbuhaler® on Lung Function Over 24-Weeks in Subjects With Moderate to Very Severe COPD
ClinicalTrials.gov study NCT02766608. IPD Sharing: Not stated. Countries: 8. Publications: 2.
Study Assessing the Long-term Effect of Dupilumab on Prevention of Lung Function Decline in Adult Patients With Uncontrolled Moderate to Severe Asthma
ClinicalTrials.gov study NCT05097287. IPD Sharing: YES. Countries: 23. Publications: 1.
A Crossover Study to Determine the Effect on Lung Function of Indacaterol in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD), Using Tiotropium as an Active Control
ClinicalTrials.gov study NCT00615459. IPD Sharing: Not stated. Countries: 7. Publications: 1.
Imaging of Chemotherapy-induced Morphological and Functional Lung Changes in Childhood ALL and HD
ClinicalTrials.gov study NCT06093334. IPD Sharing: YES. Countries: 1. Publications: 4.
A Study to Find Out Whether BI 1015550 Improves Lung Function in People With Idiopathic Pulmonary Fibrosis (IPF)
ClinicalTrials.gov study NCT05321069. IPD Sharing: YES. Countries: 37. Publications: 3.
Evaluation of the Long- Term Effects of Spiriva on Lung Function in COPD Patients
ClinicalTrials.gov study NCT00144339. IPD Sharing: Not stated. Countries: 37. Publications: 12.
Extending CPAP Therapy in Stable Preterm Infants to Increase Lung Growth and Function
ClinicalTrials.gov study NCT04295564. IPD Sharing: YES. Countries: 1. Publications: 3.
A Study to Test How Taking BI 1015550 for 12 Weeks Affects Lung Function in People With Idiopathic Pulmonary Fibrosis (IPF)
ClinicalTrials.gov study NCT04419506. IPD Sharing: YES. Countries: 22. Publications: 1.
Probiotics in COPD: Effects on Symptoms, Lung Function, and Inflammation
ClinicalTrials.gov study NCT07339280. IPD Sharing: NO. Countries: 1. Publications: 14.
A Study to Find Out Whether BI 1015550 Improves Lung Function in People With Progressive Fibrosing Interstitial Lung Diseases (PF-ILDs)
ClinicalTrials.gov study NCT05321082. IPD Sharing: YES. Countries: 45. Publications: 3.
Efficacy and Safety of Nintedanib Co-administered With Sildenafil in Idiopathic Pulmonary Fibrosis Patients With Advanced Lung Function Impairment
ClinicalTrials.gov study NCT02802345. IPD Sharing: Not stated. Countries: 13. Publications: 3.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.