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462 results for “Lung injury”
Prediction of repurposed drugs for treating lung injury in COVID-19
<p>These are output files of shared R scripts used in prediction of repurposed drugs for treating lung injury in COVID-19.</p> <p> </p> <p>R scripts are available here: https://doi.org/10.5281/zenodo.3822923</p> <p> </p> <p>Description of files:</p> <p>HCC515_6_data_for_drug.csv #Differential expression of genes in HCC515 cell at 6 h after treatment of ACE2 inhibitor</p> <p>HCC515_24_data_for_drug.csv #Differential expression of genes in HCC515 cell at 24 h after treatment of ACE2 inhibitor</p> <p>COVID19-Lung_data_for_drug.csv #Differential expression of genes in lung tissues with COVID-19</p> <p>HCC515_6_drug.csv #Drugs for HCC515 cell at 6 h after transfection of ACE2 inhibitor</p> <p>HCC515_24_drug.csv #Drugs for HCC515 cell at 24 h after transfection of ACE2 inhibitor</p> <p>COVID19-Lung_drug.csv #Drugs for lung tissuse from COVID-19 patients</p> <p>COL-3_single_treatment_response_data.csv #Differential expression of genes in HCC515 cell at 24h after treatment of COL-3</p> <p>CGP-60474_single_treatment_response_data.csv #Differential expression of genes in HCC515 cell at 24h after treatment of CGP-60474</p>
RNA sequencing of macrophages co-cultured with MSCs and RNA sequencing of alveolar macrophages from mice with lung injury treated with MSCs
<p>RNA sequencing of macrophages co-cultured with MSCS Table 5</p> <p>RNA sequencing of alveolar macrophages from mice with lung injury treated with MSCS Table 8</p>
Raw Data for the article: Donor Preconditioning with Inhaled Sevoflurane Mitigates the Effects of Ischemia-Reperfusion Injury in a Swine Model of Lung Transplantation
<p>Primary graft dysfunction (PGD) and ischemia-reperfusion injury (IRI) occur in up to 30% of patients undergoing lung transplantation and may impact on the clinical outcome. Several strategies for the prevention and treatment of PGD have been proposed, but with limited use in clinical practice. In this study, we investigate the potential application of sevoflurane (SEV) preconditioning to mitigate IRI after lung transplantation. The study included two groups of swines (preconditioned and not preconditioned with SEV) undergoing left lung transplantation after 24-hour of cold ischemia. Recipients' data was collected for 6 hours after reperfusion. Outcome analysis included assessment of ventilatory, hemodynamic, and hemogasanalytic parameters, evaluation of cellularity and cytokines in BAL samples, and histological analysis of tissue samples. Hemogasanalytic, hemodynamic, and respiratory parameters were significantly favorable, and the histological score showed less inflammatory and fibrotic injury in animals receiving SEV treatment. BAL cellular and cytokine profiling showed an anti-inflammatory pattern in animals receiving SEV compared to controls. In a swine model of lung transplantation after prolonged cold ischemia, SEV showed to mitigate the adverse effects of ischemia/reperfusion and to improve animal survival. Given the low cost and easy applicability, the administration of SEV in lung donors may be more extensively explored in clinical practice.</p>
SAFEty Study of Early Infusion of Vitamin C for Treatment of Novel Coronavirus Acute Lung Injury (SAFE EVICT CORONA-ALI)
ClinicalTrials.gov study NCT04344184. IPD Sharing: NO. Countries: 1. Publications: 10.
2D Electrial Impedance Tomography - Porcine model of Acute Lung Injury - PEEP trial
<p>This is an Electrical Impedance Tomography (EIT) dataset of a porcine model of acute lung injury (ALI), performing positive end-expiratory pressure (PEEP) trials in order to find 'optimal' PEEP.</p> <p>The data constist of 8 pigs with 2 measurements each, once before ALI and once after ALI induciton.</p> <p>Data is present as the *.bin format exported from Dräger Pulmovista V500 software. It can be read and analysed using the ALIVE eitprocessing software. </p>
Antimicrobial peptides modulate lung injury by altering the intestinal microbiota
<p>This repository contains the OTU tables for "Antimicrobial peptides modulate pulmonary inflammation by altering the intestinal microbiota" by Abdelgawad and Nicola et al., an analysis of the role of antimicrobial peptide in the gut-lung axis during hyperoxia-induced lung injury. This work was supported by the National Heart, Lung, and Blood Institute of the U.S. National Institutes of Health, K NIH: K08 HL151907 (KW), K08 HL141652 (CL), K08 DK120871 (AO); the Kaul Pediatric Research Institute at Children’s of Alabama (KW), and the Microbiome Center at UAB (KW). The funding agencies had no role in the design, conduct, and analysis of the study or in the decision to submit the manuscript for publication. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. All data in this repository is the intellectual property of the authors and may be utilized for academic publication only with prior written permission.</p>
Vitamin C Infusion for Treatment in Sepsis Induced Acute Lung Injury
ClinicalTrials.gov study NCT02106975. IPD Sharing: NO. Countries: 1. Publications: 1.
The Safety, Tolerability, PK and PD of GSK2586881 in Patients With Acute Lung Injury
ClinicalTrials.gov study NCT01597635. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Hemodynamics and Extravascular Lung Water in Acute Lung Injury
ClinicalTrials.gov study NCT00624650. IPD Sharing: Not stated. Countries: 1. Publications: 78.
CALIPSO: Calfactant for Acute Lung Injury in Pediatric Stem Cell Transplant and Oncology Patients
ClinicalTrials.gov study NCT00999713. IPD Sharing: Not stated. Countries: 2. Publications: 2.
The Role of Circulating Soluble CD74 in Acute Lung Injury
ClinicalTrials.gov study NCT02201446. IPD Sharing: NO. Countries: 1. Publications: 1.
Drug Study of Albuterol to Treat Acute Lung Injury
ClinicalTrials.gov study NCT00434993. IPD Sharing: YES. Countries: 1. Publications: 3.
Clinical Trial to Evaluate CERC-002 in Adults With COVID-19 Pneumonia and Acute Lung Injury
ClinicalTrials.gov study NCT04412057. IPD Sharing: NO. Countries: 1. Publications: 2.
LIPS-A: Lung Injury Prevention Study With Aspirin
ClinicalTrials.gov study NCT01504867. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Airway Pressure Release Ventilation in Acute Lung Injury
ClinicalTrials.gov study NCT00750204. IPD Sharing: Not stated. Countries: 1. Publications: 9.
Ventilator-induced Lung Injury Vortex in Patients With SARS-CoV-2
ClinicalTrials.gov study NCT04174313. IPD Sharing: NO. Countries: 1. Publications: 5.
Anesthetics to Prevent Lung Injury in Cardiac Surgery
ClinicalTrials.gov study NCT02918877. IPD Sharing: NO. Countries: 1. Publications: 1.
LIPS-B: Lung Injury Prevention Study With Budesonide and Beta
ClinicalTrials.gov study NCT01783821. IPD Sharing: NO. Countries: 1. Publications: 1.
A Study to Assess the Efficacy and Safety of Gimsilumab in Subjects With Lung Injury or Acute Respiratory Distress Syndrome Secondary to COVID-19 (BREATHE)
ClinicalTrials.gov study NCT04351243. IPD Sharing: NO. Countries: 1. Publications: 1.
Modulation of Lung Injury Complicating Lung Resection
ClinicalTrials.gov study NCT00655928. IPD Sharing: NO. Countries: 1. Publications: 1.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.