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ShareScore release 0.9.0
Dataset results
18 results for “Lyme borreliosis”
Out of Asia? Expansion of Eurasian Lyme borreliosis causing genospecies display unique evolutionary trajectories
<p>Vector-borne pathogens exist in obligate transmission cycles between vector and reservoir host species. Host and vector shifts can lead to geographic expansion of infectious agents and the emergence of new diseases in susceptible individuals. Three bacterial genospecies (<em>Borrelia</em> <em>afzelii</em>, <em>Borrelia</em> <em>bavariensis</em>, and <em>Borrelia</em> <em>garinii</em>) predominantly utilize two distinct tick species as vectors in Asia (<em>Ixodes</em> <em>persulcatus</em>) and Europe (<em>Ixodes</em> <em>ricinus</em>). Through these vectors, the bacteria can infect various vertebrate groups (e.g. rodents, birds) including humans where they cause Lyme borreliosis, the most common vector-borne disease in the Northern hemisphere. Yet, how and in which order the three <em>Borrelia</em> genospecies colonized each continent remains unclear including the evolutionary consequences of this geographic expansion. Here, by reconstructing the evolutionary history of 142 Eurasian isolates, we find evidence that the ancestors of each of the three genospecies likely have an Asian origin. Even so, each genospecies studied displayed a unique sub-structuring and evolutionary response to the colonization of Europe. The pattern of allele sharing between continents is consistent with the dispersal rate of the respective vertebrate hosts, supporting the concept that adaptation of <em>Borrelia</em> genospecies to the host is important for pathogen dispersal. Our results highlight that Eurasian Lyme borreliosis agents are all capable of geographic expansion with host association influencing their dispersal; further displaying the importance of host and vector association to the geographic expansion of vector-borne pathogens and potentially conditioning their capacity as emergent pathogens.</p>
Alternative Schedule Study For VLA15, a Vaccine Candidate Against Lyme Borreliosis
ClinicalTrials.gov study NCT03970733. IPD Sharing: YES. Countries: 1. Publications: 2.
Lyme Borreliosis and Early Cutaneous Diagnostic
ClinicalTrials.gov study NCT02414789. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Phase 2 Study Of VLA15, A Vaccine Candidate Against Lyme Borreliosis, In A Healthy Pediatric And Adult Study Population
ClinicalTrials.gov study NCT04801420. IPD Sharing: YES. Countries: 2. Publications: 2.
Immunogenicity and Safety Study of a Vaccine Against Lyme Borreliosis, in Healthy Adults Aged 18 to 65 Years. Randomized, Controlled, Observer-blind Phase 2 Study.
ClinicalTrials.gov study NCT03769194. IPD Sharing: Not stated. Countries: 3. Publications: 1.
Out of Asia? Expansion of Eurasian Lyme borreliosis causing genospecies display unique evolutionary trajectories
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Study Assessing the Safety, Immunogenicity and Dose Response of VLA15, A New Vaccine Candidate Against Lyme Borreliosis
ClinicalTrials.gov study NCT03010228. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Detection of Borrelia Bacteria in Early Stage Lyme Borreliosis Using the T2Lyme Panel
ClinicalTrials.gov study NCT03581279. IPD Sharing: NO. Countries: 1. Publications: 0.
Comparison of IFA and LIAISON® for Diagnosis of Early Disseminated Lyme Borreliosis in Children, Younger Than 18 Years
ClinicalTrials.gov study NCT03798704. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Effect of Saccharomyces Boulardii CNCM I-745 on Gut Microbiota in Patients Undergoing Antibiotic Therapy (in the Context of Erythema Migrans (Early Skin Form of Lyme Borreliosis))
ClinicalTrials.gov study NCT06451913. IPD Sharing: NO. Countries: 1. Publications: 0.
Performance Evaluation of the DualDur In Vitro Diagnostic System in the Diagnosis of Lyme Borreliosis
ClinicalTrials.gov study NCT03873974. IPD Sharing: UNDECIDED. Countries: 6. Publications: 0.
Perceptions,Social Representations and Experience of Lyme Borreliosis and Ticks in Adolescents Likely to be Infected and Their Parents
ClinicalTrials.gov study NCT05678478. IPD Sharing: NO. Countries: 1. Publications: 0.
Borrelia Species in Cutaneous Lyme Borreliosis
ClinicalTrials.gov study NCT00576082. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Anti-phospolipid Antibodies in Lyme Borreliosis
ClinicalTrials.gov study NCT06929546. IPD Sharing: NO. Countries: 1. Publications: 0.
Direct Diagnosis of Disseminated Lyme Borreliosis.
ClinicalTrials.gov study NCT04719962. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Effectiveness of an Intervention Combining Adapted Physical Activity and Therapeutic Education in Patients With Chronic Symptoms Attributed to Lyme Borreliosis.
ClinicalTrials.gov study NCT05641116. IPD Sharing: NO. Countries: 1. Publications: 0.
Lyme Borreliosis incidence in relation to mammalian abundance, climate, and landscape characteristics in Northern Europe
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Doxycycline Boosted Therapy in Lyme Borreliosis: DoBo Study.
ClinicalTrials.gov study NCT07230028. IPD Sharing: NO. Countries: 0. Publications: 0.
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International Brain Laboratory public data
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OpenNeuro
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