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Dataset results
105 results for “Lymphoid Progenitor”
Expression of terminal deoxynucleotidyl transferase (TdT) identifies lymphoid-primed progenitors in human bone marrow
<p><span>With emerging single-cell techniques in the human hematopoiesis, discrepancies between the traditional cell-surface-marker-based cell-type identification and their single-cell level molecular phenotype are observed. To better associate lymphoid identity with protein-level cell features, we examined the protein expression of terminal deoxynucleotidyl transferase (TdT), a specialized DNA polymerase intrinsic to VDJ recombination, and detected TdT expression within CD34+ progenitors prior to B/T cell emergence. While these TdT+ cells coincided with granulocyte-monocyte progenitor (GMP) immunophenotype, their accessible chromatin regions showed enrichment for lymphoid-associated transcription factor (TF) motifs. TdT expression on GMPs was inversely related to the SLAM family member CD84. Prospective isolation of CD84lo GMPs demonstrated robust lymphoid potential ex vivo, while still retaining significant myeloid differentiation capacity, akin to LMPPs. This multi-omic study identifies previously unappreciated lymphoid-primed progenitors, redefining the lympho-myeloid axis in human hematopoiesis.</span></p>
Expression of terminal deoxynucleotidyl transferase (TdT) identifies lymphoid-primed progenitors in human bone marrow
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EBF1 primes B-lymphoid enhancers and limits the myeloid bias in murine multipotent progenitors
<p>Haematopoietic stem cells (HSC) and multipotent progenitors (MPP) generate all cells of the blood system. Despite their multipotency, MPPs display poorly understood lineage bias. Here, we examine whether lineage-specifying transcription factors, such as the B-lineage determinant EBF1, regulate lineage preference in early progenitors. We detect low level EBF1 expression in myeloid-biased MPP3 and lymphoid-biased MPP4 cells, coinciding with expression of the myeloid determinant C/EBPα. Hematopoietic deletion of <em>Ebf1</em> results in enhanced myelopoiesis and reduced HSC repopulation capacity. <em>Ebf1</em>-deficient MPP3 and MPP4 cells exhibit augmented myeloid differentiation potential and a myeloid-enriched transcriptome that is inversely correlated with <em>Cebpa</em>-deficient progenitors. Correspondingly, EBF1 binds the <em>Cebpa</em> enhancer and <em>Ebf1</em>-deficient MPP3 and MPP4 cells upregulate <em>Cebpa </em>expression. In addition, EBF1 primes the chromatin of B-lymphoid enhancers specifically in MPP3 cells. Thus, our study implicates EBF1 in regulating myeloid/lymphoid fate bias in MPPs by constraining C/EBPα -driven myelopoiesis and priming the B-lymphoid fate.</p>
The Collection of Peripheral Blood Lymphocytes and Marrow Progenitor Cells From Normal Volunteers and Volunteers With Lymphoid or Hematologic Malignancies
ClinicalTrials.gov study NCT00001432. IPD Sharing: Not stated. Countries: 1. Publications: 3.
The transcription factor NFIL3 drives innate lymphoid cell specification from lymphoid progenitors [CUT&RUN]
GEO Series GSE291321. Mus musculus. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Transcription factor Zbtb1 interacts with bridging factor Lmo2 and maintains the T-lineage differentiation capacity of lymphoid progenitor cells
GEO Series GSE199696. Mus musculus. 21 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Common lymphoid progenitor derivation of plasmacytoid dendritic cells is mediated by Bcl11a
GEO Series GSE225768. Mus musculus. 1 samples. Type: Expression profiling by high throughput sequencing.
RNA-Seq of innate lymphoid cells generated in vitro from umbilical cord blood derived CD34+ hematopoietic progenitors.
GEO Series GSE141504. Homo sapiens. 32 samples. Type: Expression profiling by high throughput sequencing.
Reprogramming Mouse Fibroblasts into Engraftable Myeloerythroid and Lymphoid Progenitors: Induction and Underlying Mechanisms
GEO Series GSE86198. Mus musculus. 42 samples. Type: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing.
Innate Lymphoid Cells Originate from Fetal Liver-Derived Tissue-Resident Progenitors
GEO Series GSE294130. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
PU.1 is required for the developmental progression of multipotent progenitors to common lymphoid progenitors.
GEO Series GSE89642. Mus musculus. 6 samples. Type: Expression profiling by array.
Uncovering human yolk sac-derived innate lymphoid-biased multipotent progenitors prior to hematopoietic stem cell formation (CITE-Seq)
GEO Series GSE268141. Homo sapiens. 1 samples. Type: Other.
Uncovering human yolk sac-derived innate lymphoid-biased multipotent progenitors prior to hematopoietic stem cell formation
GEO Series GSE268143. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing; Other.
Gene expression of E13 fetal liver of common lymphoid progenitors Flt3+ a4b7+ compared to a4b7-HSAint, a4b7-HSAhi or a4b7-HSAlow
GEO Series GSE84366. Mus musculus. 12 samples. Type: Expression profiling by array.
Single cell RNA sequencing data of bone marrow lymphoid progenitors
GEO Series GSE100037. Mus musculus. 39 samples. Type: Expression profiling by high throughput sequencing.
Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors
GEO Series GSE92344. Mus musculus. 30 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Structural basis of epigenetic protection of mouse lymphoid progenitor cells by Dnmt1 (Medaka)
GEO Series GSE98646. Oryzias latipes. 6 samples. Type: Methylation profiling by high throughput sequencing.
Uncovering human yolk sac-derived innate lymphoid-biased multipotent progenitors prior to hematopoietic stem cell formation (scRNA-Seq)
GEO Series GSE268142. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
The transcription factor NFIL3 drives innate lymphoid cell specification from lymphoid progenitors [RNA-seq - Tox]
GEO Series GSE291316. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Structural basis of epigenetic protection of mouse lymphoid progenitor cells by Dnmt1 [Mouse WGBS]
GEO Series GSE142834. Mus musculus. 12 samples. Type: Methylation profiling by high throughput sequencing.
ScienceDex guides
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.