Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
124
datasets available to search
ShareScore release 0.9.0
Dataset results
124 results for “Lymphoid tissue”
Double-negative B cells and DNASE1L3 colocalise with microbiota in gut-associated lymphoid tissue - IMC+RNAScope images
<p><span>Intestinal homeostasis is maintained by the response of gut-associated lymphoid tissue to bacteria transported across the follicle associated epithelium into the subepithelial dome. The initial response to antigens and how bacteria are handled is incompletely understood. By iterative application of spatial transcriptomics and multiplexed single-cell technologies, we identify that the double negative 2 subset of B cells, previously associated with autoimmune diseases, is present in the subepithelial dome in health. We show that in this location double negative 2 B cells interact with dendritic cells co-expressing the lupus autoantigens DNASE1L3 and C1q and microbicides.<span> </span>We observe that in humans, but not in mice, dendritic cells expressing DNASE1L3 are associated with sampled bacteria but not DNA derived from apoptotic cells. We propose that fundamental features of autoimmune diseases are microbiota-associated, interacting components of normal intestinal immunity.</span></p>
Distinct tissue-dependent composition and gene expression of human fetal innate lymphoid cells
<p>Countmatrix and metadata for gene expression in bulk NK cells and CD304+ ILC3s isolated from human fetal liver, lung, intestine, and skin. </p>
Diversity of group 1 innate lymphoid cells in human tissues
<p>Group 1 innate lymphoid cells (ILC1s) are cytotoxic and interferon gamma-producing lymphocytes lacking antigen-specific receptors, which include ILC1s and natural killer (NK) cells. In mice, ILC1s differ from NK cells, as they develop independently of the NK-specifying transcription factor EOMES, while requiring the repressor ZFP683 (ZNF683 in humans) for tissue residency. Here we identify highly variable ILC1 subtypes across tissues through investigation of human ILC1 diversity by single-cell RNA sequencing and flow cytometry. The intestinal epithelium contained abundant mature EOMES<sup>-</sup> ILC1s expressing PRDM1 rather than ZNF683, alongside a few immature TCF7<sup>+</sup>PRDM1<sup>-</sup> ILC1s. Other tissues harbored NK cells expressing ZNF683 and EOMES transcripts; however, EOMES protein content was variable. These ZNF683<sup>+</sup> NK cells are tissue-imprinted NK cells phenotypically resembling ILC1s. The tissue ILC1-NK spectrum also encompassed conventional NK cells and NK cells distinguished by PTGDS expression. These findings establish a foundation for evaluating phenotypic and functional changes within the NK-ILC1 spectrum in diseases.</p>
Evaluation of archival HIV DNA in brain and lymphoid tissues
<p>HIV reservoirs persist in anatomic compartments despite antiretroviral therapy (ART). Characterizing HIV reservoirs in central nervous system (CNS) and other tissues is crucial to inform cure strategies. We evaluated paired autopsy brain – frontal cortex (FC), occipital cortex (OCC), basal ganglia (BG) – and peripheral lymphoid tissues from 63 people with HIV. Participants passed away while virally suppressed on ART and without evidence of CNS opportunistic disease. We quantified HIV DNA and, from a subset of 14 participants, we obtained full-length HIV-envelope (FL HIV-env) sequences. We detected HIV DNA (<em>gag</em>) in most brain (65.1%) and all lymphoid tissues. Lymphoid tissues had higher HIV DNA levels compared to brain (p<0.01). Levels of HIV <em>gag</em> between BG and FC were similar (p>0.2), while OCC had the lowest levels (p=0.01). Females had higher HIV DNA levels in tissues than males (<em>gag</em>: p=0.03; 2-LTR, p=0.05), suggesting possible sex-associated mechanisms for HIV reservoir persistence. Most FL HIV-env sequences (n=143) were intact, while 42 were defective. Clonal sequences were found in eight participants; one participant had the same clonal defective sequences in brain and spleen, suggestive of cell migration. From 10 donors with paired brain and lymphoid sequences, we observed evidence of compartmentalized sequences in two participants. Our data contribute to the idea that the brain is a site for HIV reservoirs during ART where compartmentalized proviral populations may occur in a subset of people. Future studies accessing FL HIV-provirus and replication competence in vitro are needed to further evaluate the HIV reservoirs' composition in tissues.</p>
Radiation Therapy Alone for the Treatment of Stage 1 and 2 Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma
ClinicalTrials.gov study NCT04465162. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Rituximab Plus Lenalidomide in Patients With Mucosa Associated Lymphoid Tissue
ClinicalTrials.gov study NCT01611259. IPD Sharing: NO. Countries: 1. Publications: 1.
A Pilot Project of Virologic, Pharmacologic and Immunologic Correlates of Gastrointestinal-Associated Lymphoid Tissue Immune Reconstitution Following Maraviroc Therapy
ClinicalTrials.gov study NCT00870363. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Data from: Vaccine targeting to mucosal lymphoid tissues promotes humoral immunity in the gastrointestinal tract
Open the record for dataset details and reuse information.
Sepsis restructures the mitochondrial calcium uniporter complex in the lymphoid tissues of mice and humans
Open the record for dataset details and reuse information.
Evaluation of archival HIV DNA in brain and lymphoid tissues
Open the record for dataset details and reuse information.
Presence of tertiary lymphoid structures and exhausted tissue-resident T cells determines clinical response to PD-1 blockade in renal cell carcinoma
Open the record for dataset details and reuse information.
Trial of Lenalidomide in Patients With Lymphoma of the Mucosa Associated Lymphoid Tissue (MALT) Type
ClinicalTrials.gov study NCT00923663. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of Cell Surface Markers and Lymphoid Cell Distribution on the Arterial Tissue Repair (ECLAR)
ClinicalTrials.gov study NCT02421081. IPD Sharing: Not stated. Countries: 1. Publications: 10.
Residual Replication of HIV-1 in the Gut Associated Lymphoid Tissue (GALT) of Patients on Highly Active Antiretroviral Therapy (HAART): the ANRS EP 44 Study
ClinicalTrials.gov study NCT01038401. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Trial of Bendamustine And Rituximab for Patients With Previously Untreated Extranodal Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma
ClinicalTrials.gov study NCT01015248. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Antiretroviral Localization in Gut-Associated Lymphoid Tissue and Lower Female Genital Tract Tissue of HIV+ Subjects
ClinicalTrials.gov study NCT02641444. IPD Sharing: NO. Countries: 1. Publications: 2.
A Study of Lymphoseek® as a Lymphoid Tissue Targeting Agent in Pediatric Patients With Melanoma, Rhabdomyosarcoma, or Other Solid Tumors Who Are Undergoing Lymph Node Mapping
ClinicalTrials.gov study NCT02509598. IPD Sharing: NO. Countries: 1. Publications: 0.
Lymphoseek® as Lymphoid Tissue Targeting Agents in Colon Cancer(CNC)
ClinicalTrials.gov study NCT01902953. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Lymphoid Tissue Pharmacology of Antiretroviral Drugs
ClinicalTrials.gov study NCT02707926. IPD Sharing: YES. Countries: 0. Publications: 2.
Transcription factor TCF-1 regulates the functions but not the development of lymphoid tissue inducer subsets in different tissues [RNA-seq]
GEO Series GSE190299. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.