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84 results for “MC38”
RNAseq transcriptome of draining lymph node (LN) and tumor of MC38 murine tumors treated with cryoablation and chitosan/IL-12
<p class="MsoNormal">Focal ablation technologies are routinely used in the clinical management of inoperable solid tumors but often result in incomplete ablations leading to high recurrence rates. Adjuvant therapies capable of safely eliminating residual tumor cells are therefore of great clinical interest. Interleukin 12 (IL-12) is a potent antitumor cytokine that can be localized intratumorally through coformulation with <span>viscous biopolymers</span> including chitosan (CS) solutions. The objective of this research was to determine if localized immunotherapy with CS/IL-12 could prevent <span>tumor recurrence after cryoablation (CA). Tumor recurrence, overall survival, and protective immunity were assessed. Systemic immunity was evaluated in spontaneously metastatic and bilateral tumor models. Temporal bulk RNA sequencing was performed on tumor and draining lymph node samples.</span> In multiple murine tumor models, the addition of CS/IL-12 to CA reduced recurrence rates by 30–55%. Altogether, this cryo-immunotherapy induced complete durable regression of large tumors in 80–100% of treated animals. <span>Mice</span> treated with CA plus adjuvant CS/IL-12 were partially or completely protected from tumor rechallenge. <span>Systemically,</span> CS/IL-12 prevented lung metastases when delivered as a neoadjuvant to CA. However, CA plus CS/IL-12 had minimal antitumor activity against established, untreated abscopal tumors. Adjuvant anti-PD-1 therapy delayed the growth of abscopal tumors. Transcriptome analyses revealed early immunological changes in <span>the dLN</span>, followed by a significant increase in gene expression associated with immune suppression and regulation. Cryo-immunotherapy with localized CS/IL-12<span> reduces recurrences and</span> enhances the elimination of large primary tumors<span>. This focal combination therapy also induces significant systemic</span> antitumor immunity <span>although further studies are necessary</span>.</p>
RNAseq transcriptome of draining lymph node (LN) and tumor of MC38 murine tumors treated with cryoablation and chitosan/IL-12
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Photoconversion of MC38
GEO Series GSE193654. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional response to vanoxerine in vivo treatments in MC38 colorectal tumors
GEO Series GSE207032. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
RNA Sequencing Identification of MC38-P and Its Liver Metastatic Derivatives, MC38-LM3a and MC38-LM3b [Bulk RNA-seq]
GEO Series GSE290134. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profile of tumor infiltrating cells in MC38 tumor that grown on C57/Bl6 mice subjected to total body irradiation (TBI) with ABT263 treatment,
GEO Series GSE256486. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
MC38 tumors from mice fed high-fat or control diet
GEO Series GSE157999. Mus musculus. 43 samples. Type: Expression profiling by high throughput sequencing.
Effects of Id1 depletion in TAMs on the genes expression of MC38 cells.
GEO Series GSE200855. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic profiling of the cancer-associated fibroblasts (CAFs) on murine MC38 liver metastasis sections by NanoString GeoMX DSP
GEO Series GSE225456. Mus musculus. 10 samples. Type: Other.
scRNA-Seq of MC38 CD45+ Cells treated with EZH2 inhibitor PF-06821497
GEO Series GSE188473. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
TCR profiling of whole MC38 tumors, treated with PBS + IgG , Cis + PBS + aPD-1, Cis + DCP-IL-12/FLT3L + IgG or Cis + DCP-IL-12/FLT3L + ɑPD-1.
GEO Series GSE228161. Mus musculus. 22 samples. Type: Other.
Bulk RNA-seq of CD11b+ cells from MC38 tumours in Kaede transgenic mice
GEO Series GSE298881. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Tumor immune evasion arises through loss of TNF sensitivity [MC38]
GEO Series GSE112252. Mus musculus. 28 samples. Type: Expression profiling by high throughput sequencing.
The scRNA-seq analysis of immune cells in colorectal cancer liver metastatic lesions formed by MC38-LM3b-shScramble and MC38-LM3b-shSLAMF3.
GEO Series GSE290135. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome analysis of CD4+ T cells from spleen and MC38 tumor
GEO Series GSE134851. Mus musculus. 5 samples. Type: Expression profiling by high throughput sequencing.
scRNA-seq of myeloid cells from subcutaneous MC38-Ova tumours and draining lymph nodes (LN) in photoconvertible Kaede mice
GEO Series GSE221513. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
T cells and Dendritic cells from MC38 tumors treated with anti-PD-1 or anti-PD-1 plus D18
GEO Series GSE146784. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Effects of Id1 depletion in TAMs on the genes expression of MC38 cells.
GEO Series GSE188572. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Profiling the inflammatory signatures of bulk MC38, Pan02 and KPC tumors from wild-type mice and Sirpα-KO mice before and after radiation therapy
GEO Series GSE149882. Mus musculus. 12 samples. Type: Expression profiling by array.
m6A-seq analysis of Mettl3fl/fl (WT) and Mettl3fl/fl,LyzM-cre (cKO) bone-marrow-derived macrophages (BMDMs) transcriptomes after co-culturing with MC38 cells
GEO Series GSE189994. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
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