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4 results for “MDF”
20211118_CircAgro_Primary data of Lungau farms and MDF
<p>For a description of the dataset, please see: Readme file for 20211118_CircAgro_Primary data of Lungau farms and MDF.txt</p>
RNA-seq and RT-qPCR data showing MDF role in RNA splicing and gene expression control in Arabidopsis
<p>Plants respond to environmental stresses through controlled stem cell maintenance and meristem activity. One level of transcriptional control is RNA alternative splicing. However the mechanistic link between stress, meristem function and RNA splicing is poorly understood. The MERISTEM-DEFECTIVE (MDF)/DEFECTIVELY ORGANIZED TRIBUTARIES (DOT2) gene of Arabidopsis encodes a SR-related family protein, required for meristem function and leaf vascularization, and is the likely orthologue of the human SART1 and yeast snu66 splicing factors. MDF is required for the correct splicing and expression of key transcripts associated with root meristem function. We identified RSZ33 and ACC1, both known to regulate cell patterning, as splicing targets required for MDF function in the meristem. MDF expression is modulated by osmotic and cold stress, associated with differential splicing and specific isoform accumulation and shuttling between nucleus and cytosol, and acts in part via a splicing target SR34. We propose a model in which MDF controls splicing in the root meristem to promote stemness and repress stress response and cell differentiation pathways.</p>
RNA-seq and RT-qPCR data showing MDF role in RNA splicing and gene expression control in Arabidopsis
Open the record for dataset details and reuse information.
Analyses of the transcriptional and alternative splicing changes in mdf-1 in comparison to WT via RNA sequencing
GEO Series GSE197898. Arabidopsis thaliana. 6 samples. Type: Expression profiling by high throughput sequencing.
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