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140 results for “Malignant transformation”
Knockout of liver fluke granulin, Ov-grn-1, impedes malignant transformation during chronic infection with Opisthorchis viverrini: BrdU staining and fibrosis
<p>Knockout of liver fluke granulin, Ov-grn-1, impedes malignant transformation during chronic infection with Opisthorchis viverrini:</p> <p>1. BrdU stained images for the detection of proliferation with manual counting of brown stained cell proportion. Each group in a seperate file BRDUxxx</p> <p>2. Fibrosis local images stained with Sirius red with automated analysis with imageJ. Grouped into one zip file</p> <p>3. Global analysis of liver fibrosis pathogenesis (Ishak scores) performed by 2 blinded pathologists. Grouped into one zip file</p> <p>Methods in associated publication. Briefly 3 groups of 15 hamsters were infected with 100 NEJ flukes that had been gene edited with CRISPR/Cas9 plasmids targeting either Ov-grn-1, Ov-tsp-2, or a scrambled sequence as the control group. Images in these files are the micrographs from these three groups of hamsters. Numbered 1-15 representing the hamster and left/middle/right representing the liver lobe the section was taken from.</p> <p> </p> <p>Knockout of liver fluke granulin, Ov-grn-1, impedes malignant transformation during chronic infection with Opisthorchis viverrini</p> <p>ABSTRACT: Infection with the food-borne liver fluke <em>Opisthorchis viverrini</em> is the principal risk factor for cholangiocarcinoma (CCA) in the Mekong Basin countries of Thailand, Lao PDR, Vietnam, Myanmar and Cambodia. Using a novel model of CCA, involving infection with gene-edited liver flukes in the hamster during concurrent exposure to dietary nitrosamine, we explored the role of the fluke granulin-like growth factor <em>Ov</em>-GRN-1 in malignancy. We derived RNA-guided gene knockout flukes (<em>ΔOv-grn-1)</em> using CRISPR/Cas9/gRNA materials delivered by electroporation. Genome sequencing confirmed programmed Cas9-catalyzed mutations of the targeted genes, which was accompanied by rapid depletion of transcripts and the proteins they encode. Gene-edited parasites colonized the biliary tract of hamsters and developed into adult flukes. However, less hepatobiliary tract disease manifested during chronic infection with <em>ΔOv-grn-1</em> worms in comparison to hamsters infected with control gene-edited and mock-edited parasites. Specifically, immuno- and colorimetric-histochemical analysis of livers revealed markedly less periductal fibrosis surrounding the flukes and less fibrosis globally within the hepatobiliary tract during infection with <em>ΔOv-grn-1</em> genotype worms, minimal biliary epithelial cell proliferation, and significantly fewer mutations of <em>TP53</em> in biliary epithelial cells. Moreover, fewer hamsters developed high-grade CCA compared to controls. The clinically relevant, pathophysiological phenotype of the hepatobiliary tract confirmed a role for this secreted growth factor in malignancy and morbidity during opisthorchiasis.</p>
Saliva and Plasma Exosomes for Oral Leukoplakia Malignant Transformation Diagnosis and Oral Cancer Prognosis Monitoring
ClinicalTrials.gov study NCT06469892. IPD Sharing: YES. Countries: 1. Publications: 14.
Methylation of p16 CpG Island And Malignant Transformation of Oral Epithelial Dysplasia
ClinicalTrials.gov study NCT00835341. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Transformation of Plexiform Neurofibromas to Malignant Peripheral Nerve Sheath Tumors in Neurofibromatosis Type 1
ClinicalTrials.gov study NCT02211768. IPD Sharing: YES. Countries: 1. Publications: 3.
Sensitivity and Specificity of Serum and Salivary CYFRA21-1 in the Detection of Malignant Transformation in Oral Potentially Malignant Mucosal Lesions (Diagnostic Accuracy Study)
ClinicalTrials.gov study NCT03686020. IPD Sharing: UNDECIDED. Countries: 1. Publications: 7.
Syndrome Patterns for Chronic Atrophic Gastritis Malignant Transformation
ClinicalTrials.gov study NCT03314038. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study of Metabolic Changes in the Transformation Malignant Precancerous Skin Lesions
ClinicalTrials.gov study NCT04389112. IPD Sharing: NO. Countries: 1. Publications: 4.
Transcriptome profiling of the interconnection of pathways involved in malignant transformation and response to hypoxia
GEO Series GSE109367. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
The Pediatric Leukemia Oncoprotein NUP98-KDM5A Induces Genomic Instability That May Facilitate Malignant Transformation
GEO Series GSE224499. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Smc3 regulates B-cell transit through germinal centers and restricts their malignant transformation
GEO Series GSE143852. Mus musculus. 29 samples. Type: Other; Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Genomic analyses reveal miR-137 broad impact on genes associated with malignant transformation and neuronal differentiation in glioblastoma cells
GEO Series GSE53220. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing; Other.
Multi-omics datasets for finer-scale dissection of chromatin architecture alterations in radiation induced malignant transformation of bronchial epithelial cells [RNA-seq]
GEO Series GSE175859. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Dynamics of MBD2 deposition across methylated DNA regions during malignant transformation of human mammary epithelial cells
GEO Series GSE63237. Homo sapiens. 30 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by genome tiling array; Methylation profiling by genome tiling array.
Loss of NF2 drives malignant transformation of human pancreatic acinar cells and enhances cell fitness under nutrient deprivation and therapeutical stress [CRISPR_screen]
GEO Series GSE292511. Homo sapiens. 16 samples. Type: Other.
Loss of NF2 drives malignant transformation of human pancreatic acinar cells and enhances cell fitness under nutrient deprivation and therapeutical stress [single_cell_RNAseq]
GEO Series GSE292513. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Nanolipoprotein mediated Her2 protein transfection induces malignant transformation in human breast acinar cultures
GEO Series GSE184648. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
The cellular origin and malignant transformation of Waldenström's Macroglobulinemia [copy number variation]
GEO Series GSE61650. Homo sapiens. 59 samples. Type: Genome variation profiling by SNP array.
Loss of NF2 drives malignant transformation of human pancreatic acinar cells and enhances cell fitness under nutrient deprivation and therapeutical stress [bulk_RNAseq]
GEO Series GSE292512. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
PU.1-dependent enhancer inhibition separates clonal hematopoiesis from malignant transformation (RNA-Seq)
GEO Series GSE186146. Mus musculus. 17 samples. Type: Expression profiling by high throughput sequencing.
Cellular identity loss occurring during both iPS cells generation and malignant transformation can be followed using the somatic markers Thy1 and Bcl11b [scRNA-seq]
GEO Series GSE181451. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.