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202 results for “Megakaryocytes”
Megakaryocyte volume modulates bone marrow niche properties and cell migration dynamics
<p>Supplementary videos showing raw time and z-stacks as well a final, processed result for Neutrophil tracking in naive and platelet depleted mouse.</p> <p>Matlab scripts to run simulation of megakaryocytes, neutrophils and hematopoetic stem cell in a vessel environment.</p> <p>Ilastik training data set used in segmentation of bone and bone marrow.</p> <p> </p>
Global Characterization of Megakaryocytes in Bone Marrow, Peripheral Blood, and Cord Blood by Single-cell RNA Sequencing
<p><span><span>Megakaryocytes (MK) are mainly derived from bone marrow (BM) and are mainly involved in platelet production. Recent studies have shown that MK derived from BM may have immune function, and that MK from peripheral blood (PB) are associated with prostate cancer. We analyzed more than 1.2 million single-cell transcriptome data from 132 samples of PB, BM, and cord blood (CB) from healthy individuals and patients, and obtained 4474 MK single cell and 14 MK subtypes. We found that MK were widely distributed and the amount of MK in PB was more than that in BM and there were specificity MK subtypes in PB. We found classical MK1 with typical MK characteristics and non-classical MK2 closely related to immunity which was the most common subtype in BM and CB. Classical MK1 was closely related to Non-Small Cell Lung Cancer (NSCLC) and has diagnostic ability. MK2 may have potential adaptive immune function and play a role in tumor NSCLC and autoimmune diseases Systemic Lupus Erythematosus. This study deepened our understanding of MK and suggested that MK had potential immune functions and was involved in various diseases.</span></span></p>
Global Characterization of Megakaryocytes in Bone Marrow, Peripheral Blood, and Cord Blood by Single-cell RNA Sequencing
Open the record for dataset details and reuse information.
Critical shifts in lipid metabolism promote megakaryocyte differentiation and proplatelet formation
<p>During megakaryopoiesis, megakaryocytes (MK) undergo cellular morphological changes with strong modification of membrane composition and lipid signaling. Here we adopt a lipid-centric multiomics approach to create a quantitative map of the MK lipidome during maturation and proplatelet formation. Data reveal that MK differentiation is driven by an increased fatty acyl import and <em>de novo</em> lipid synthesis, resulting in an anionic membrane phenotype. Pharmacological perturbation of fatty acid import and phospholipid synthesis blocked membrane remodeling and directly reduced MK polyploidization and proplatelet formation resulting in thrombocytopenia. The anionic lipid shift during megakaryopoiesis was paralleled by lipid-dependent relocalization of the scaffold protein CKIP-1 and recruitment of the kinase CK2α to the plasma membrane, which seems to be essential for sufficient platelet biogenesis. Overall, this study provides a framework to understand how the MK lipidome is altered during maturation and the impact of MK membrane lipid remodeling on MK kinase signaling involved in thrombopoiesis.</p>
Megakaryocytic Progenitor Cells for Prophylaxis and Treatment of Thrombocytopenia
ClinicalTrials.gov study NCT02241031. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Megakaryocyte
SciDraw upload
GATA1-defective megakaryocytes as possible drivers of idiopathic pulmonary fibrosis
<p>To be done</p>
Study of Megakaryocytes From Patients With Abnormal Platelet Vesicles
ClinicalTrials.gov study NCT00086476. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Single cell transcriptomics of hiPSC-derived forward programmed megakaryocytes
GEO Series GSE121579. Homo sapiens. 192 samples. Type: Expression profiling by high throughput sequencing.
total RNA-seq from megakaryocyte progenitor cell (ENCSR848LXY)
GEO Series GSE88585. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide localization of NF-E2 p45 in mouse primary megakaryocytes.
GEO Series GSE42249. Mus musculus. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Treatment of CHRF288-11 Megakaryocytic Cells with Wnt compounds
GEO Series GSE42071. Homo sapiens. 12 samples. Type: Expression profiling by array.
DNMT3A regulates megakaryocyte-biased hematopoietic stem cell fate decisions [RNASeq]
GEO Series GSE276901. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Beclin 1 of megakaryocytic lineage cells is locally dispensable for platelet hemostasis but functions distally in bone homeostasis
GEO Series GSE283093. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
total RNA-seq from megakaryocyte (ENCSR340NCF)
GEO Series GSE88202. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Shear flow vs. static culture of d9 and d12 megakaryocytes
GEO Series GSE75766. Homo sapiens. 18 samples. Type: Expression profiling by array.
RNA-Seq Analysis of Gfi1b KO Megakaryocytes
GEO Series GSE71310. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Impact of Elevated Plasma 5-HT on Global Gene Expression of Murine Megakaryocytes
GEO Series GSE37273. Mus musculus. 7 samples. Type: Expression profiling by array.
Decoding Human Megakaryocyte Development
GEO Series GSE144024. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
PF4-Cre mediated deletion of SRF in murine megakaryocytes.
GEO Series GSE21859. Mus musculus. 6 samples. Type: Expression profiling by array.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
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