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10 results for “Mesolimbic”
BRAIN Journal-Electrophysiological Neuroimaging using sLORETA Comparing 100 Schizophrenia Patients to 48 Patients with Major Depression -Figure 3. Resulting comparisons isolating the Dopamine D2 Mesolimbic Pathway
<p>Moreover, a study in Prague identified that Toxoplasmosis triggers schizophrenia in<br> predisposed subjects (Flegr et al., 2014). It may very well be that the Toxoplasmosis parasite<br> increasing dopamine secretions in the frontal lobes may very well lead to decreased cerebral<br> volumes. Cat feces, sexual contact, and eating raw or undercooked pork are well known transmitters<br> of the Toxoplasmosis parasite and may be advisable that patients take precautions of the possibility<br> of these triggering symptoms of psychosis with these possible routes of infection. Another adjunct to Atypical Antipsychotics may be to treat the potential cerebral Toxoplasmosis infection with<br> Cotrimoxazole or Pyrimethamine/Clindamycin.</p>
BRAIN Journal-Electrophysiological Neuroimaging using sLORETA Comparing 100 Schizophrenia Patients to 48 Patients with Major Depression -Figure 1. Group comparisons designed for isolating the mesolimbic Dopamine D2
<p>All patients diagnosed with Schizophrenia were medicated with atypical antipsychotics, Olanzapine (dose 5mg/day to 20mg/day) or Risperidone (dose 1mg/day to 4mg/day) blocking both Dopamine D2 and Serotonin 5-HT2 receptors. Whereas, all of the patients diagnosed with Major Depression or Depressive Episode were medicated with Sertraline (50mg/day to 200mg/day maximum dose) or Citalopram (20mg/day to 40mg/day maximum dose). This research protocol was approved by the Bioethical Commission of the Medical University of Lublin. </p>
Mesolimbic dopamine neurons drive infradian rhythms in sleep-wake and heightened activity state
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Insulin sensitivity in mesolimbic pathways predicts and improves with weight loss in older dieters
<p><span>Central insulin is involved in the regulation of hedonic feeding. Insulin resistance in overweight has recently been shown to reduce the inhibitory function of insulin in the human brain, but how this affects future weight management is unclear. Also unknown is the role of central insulin sensitivity on eating behavior of older people, who are highly vulnerable to hyperinsulinemia and in whom neural target systems of insulin action undergo age-related changes. Here, fifty overweight, pre-diabetic elderly participated in a double-blind, placebo-controlled pharmacological fMRI study before and after randomization to a 3-month caloric restriction or active waiting group. We show that treatment outcome in dieters can be predicted by baseline measures of individual intranasal insulin (INI) inhibition of value signals in the ventral tegmental area related to sweet food liking as well as, independently, by peripheral insulin sensitivity. At follow-up, both INI inhibition of hedonic value signals in the nucleus accumbens and whole-body insulin sensitivity improved with weight loss. These data highlight the critical role of central insulin function in mesolimbic systems for future weight management in humans and directly demonstrate that neural insulin function can be improved by weight loss even in older age, which may be essential for preventing metabolic disorders in later life.</span></p>
Insulin sensitivity in mesolimbic pathways predicts and improves with weight loss in older dieters
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An endogenous GLP-1 circuit engages VTA GABA neurons to regulate mesolimbic dopamine neurons and attenuate cocaine seeking
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Characterization of the Relationship Between the Human Mesolimbic Reward System and Immune Functioning
ClinicalTrials.gov study NCT03951870. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Opioid withdrawal produces sex-specific effects on fentanyl-vs.-food choice and mesolimbic transcription
GEO Series GSE173959. Rattus norvegicus. 24 samples. Type: Expression profiling by high throughput sequencing.
Effects of Aripiprazole and Haloperidol on Mesolimbic System Functioning
ClinicalTrials.gov study NCT01161277. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Gene expression profiling of inputs to the mesolimbic dopamine circuit
GEO Series GSE95234. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.