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35 results for “Metabolic depression”
Treating Immuno-metabolic Depression With Anti-inflammatory Drugs
ClinicalTrials.gov study NCT05415397. IPD Sharing: YES. Countries: 1. Publications: 10.
Metabolic depression in sea urchin barrens associated with food deprivation
<p>The proliferation of sea urchins can decimate macroalgal forests in coastal ecosystems, leading to persistent barren seascapes. While kelp forests are among the most productive ecosystems on the planet, productivity in these urchin barrens is dramatically reduced. Moreover, urchins inhabiting these food-depauperate barrens face starvation and many survive in these barrens for years or decades. Urchins in barrens can persist by eating food subsidies from drift algae, pelagic salps, tubeworms, as well as encrusting and filamentous algae, microbial mats, and slow-growing species resistant to herbivory. Despite both food from endogenous production and exogenous subsidies, many urchins in barrens likely experience prolonged food deprivation. This resource limitation may create a trade-off between reproduction and survival; for example, fecundity of purple sea urchins (<em>Strongylocentrotus purpuratus</em>) is 99.9% lower in barrens. Despite food constraints, red sea urchins (<em>Mesocentrotus franciscanus</em>), the dominant urchin species at our study sites, can live in excess of 100 years and barrens in Haida Gwaii, British Columbia (BC), Canada, have persisted for at least 143 years. While these phenomena are widespread and well documented, the bioenergetic adaptations that allow urchins to persist in these food-depauperate barrens remain poorly understood. To quantify habitat-specific differences in metabolic rates and energy reserves (as measured by gonadal mass), we conducted respirometry on and measured gonadal mass in <em>M. franciscanus</em> at three locations in BC inside and outside of adjacent kelp forest and barrens habitat. Here we demonstrate that <em>M. franciscanus</em> in barrens versus kelp forests have substantially lower energy reserves and, importantly, also exhibit dramatic reductions in size-specific resting metabolic rates (RMR), even after standardizing by metabolically active body mass. On average, gonadal mass was 44.6% lower and RMR scaled to metabolically active body mass was 40% lower in barrens urchins than in kelp forest urchins. Such a shift in metabolic rate may provide a mechanism that facilitates barren state stability over long time scales as <em>M. franciscanus</em> can lower energetic demands while they wait for small pulses of food, scrape by on low-productivity resources, and suppress recruitment of macroalgae for months, years, or decades.</p>
Effect of Probiotics "Psychobiotics" on Depression and Metabolic Syndrome in Saudi Arabia
ClinicalTrials.gov study NCT06765057. IPD Sharing: YES. Countries: 1. Publications: 10.
The Influence of Probiotic Supplementation on Depressive Symptoms, Inflammation and Oxidative Stress Parameters and Faecal Microbiota in Patients With Depression Depending on Metabolic Syndrome Comorb
ClinicalTrials.gov study NCT04756544. IPD Sharing: UNDECIDED. Countries: 1. Publications: 6.
Ketogenic Metabolic Therapy in Schizophrenia, Bipolar Disorder, Major Depressive Disorder: Deep Omic Profiling
ClinicalTrials.gov study NCT06748950. IPD Sharing: NO. Countries: 1. Publications: 1.
Reducing Disparities in Late Life Depression and Metabolic Syndrome
ClinicalTrials.gov study NCT01428791. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Determine The Percentage Of Depressed Outpatients Who Do Not Effectively Metabolize Extended-release Venlafaxine HCl
ClinicalTrials.gov study NCT00788944. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of Psilocybin Only and Psilocybin Assisted Cognitive Behavioral Therapy in the Management of Major Depressive Disorder and Associated Metabolic, Immune, Inflammatory, Neuroplasticity and Electr
ClinicalTrials.gov study NCT06746441. IPD Sharing: YES. Countries: 1. Publications: 5.
Data from: Metabolic depression and the evolution of hypoxia tolerance in threespine stickleback, Gasterosteus aculeatus
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Metabolic depression in sea urchin barrens associated with food deprivation
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Exploring the Effects of Coenzyme Q10 on Bioenergetics Metabolism in Geriatric Bipolar Depression
ClinicalTrials.gov study NCT01390389. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Brain Energy Metabolism in Individuals With Major Depressive Disorder Receiving Escitalopram
ClinicalTrials.gov study NCT00183677. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Role of Dopamine Metabolism in the Antidepressant Effects of Sleep Deprivation and Sertraline in Depressed Patients
ClinicalTrials.gov study NCT00581009. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Pioglitazone for the Treatment of Major Depressive Disorder Comorbid With Metabolic Syndrome
ClinicalTrials.gov study NCT00671515. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: Calorespirometry reveals that goldfish prioritize aerobic metabolism over metabolic rate depression in all but near-anoxic environments
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EZHIP boosts neuronal-like synaptic gene programs and depresses polyamine metabolism in human neural models
GEO Series GSE291006. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Determination Physical Activity Levels,Quality Life,Depression and Fatigue Severity Individuals With Metabolic Syndrome
ClinicalTrials.gov study NCT05184634. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Use of Multiple Brain Imaging Modalities (PET and MRS) to Identify Metabolic Abnormalities in Major Depression
ClinicalTrials.gov study NCT01465165. IPD Sharing: YES. Countries: 1. Publications: 0.
Exploring Blood Plasma Metabolomics: Unraveling the Metabolic Landscape in Treatment-Resistant Adolescent Depression
ClinicalTrials.gov study NCT06331572. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Vitamin D for Improving Metabolic Control and Depressive Symptoms
ClinicalTrials.gov study NCT01185574. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.