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ShareScore release 0.9.0
Dataset results
12 results for “Metabolic endotoxemia”
Yogurt supplementation attenuates insulin resistance in obese mice by reducing metabolic endotoxemia and inflammation
<p><strong>Background</strong></p> <p>Inflammation is an underlying mechanism for development of obesity-related health complications. Yogurt consumption inhibits obesity-associated inflammation, but the tissue-specific mechanisms have not been adequately described.</p> <p><strong>Objectives</strong></p> <p>We aimed to determine the tissue-specific responses by which yogurt supplementation inhibits inflammation.</p> <p><strong>Methods</strong></p> <p>C57BL/6 male mice (5 weeks old) were fed a Teklad Global 14% Protein Rodent Maintenance diet as a control or a high-fat diet (60% calories from fat) to induce obesity for 11 weeks, followed by feeding a Western diet (WD; 43% carbohydrate & 42% fat) or WD supplemented with 5.6 % lyophilized yogurt powder for 3 weeks to test for the impact of yogurt supplementation. Markers of metabolic endotoxemia and inflammation were assessed in plasma and tissues. Cecal and fecal microbiota were profiled by 16S rRNA sequencing.</p> <p><strong>Results</strong></p> <p>In obese mice, relative to the WD control group, yogurt supplementation attenuated HOMA-IR by 57%) (p=0.020), plasma TNF-a by 31% (p<0.05) and colonic IFN-g by 46% (p=0.0034), which were accompanied by a 40% reduction in plasma LBP (p=0.0019) and 45% less colonic <em>Lbp</em> expression (p=0.037), as well as alteration in the beta diversity of cecal microbiota (p=0.0090) and relative abundance of certain cecal microbes (e.g., <em>Lachnospiraceae Dorea longicatena</em> with p=0.049). There were no differences in the LBP, <em>Lbp</em>, and <em>Cd14</em> levels in the liver and small intestine between obese mice with and without yogurt supplementation (p>0.05).</p> <p><strong>Conclusions</strong></p> <p>Yogurt consumption inhibited obesity-induced inflammation in mice by modulating colonic endotoxin detoxification, changing the gut microbiota, and improving glucose metabolism. This work helps to establish the underlying mechanisms by which yogurt consumption affects markers of metabolic and immune health.</p>
The Effect of Ketogenic-caloric Restricted Diet on Metabolic Endotoxemia in Prediabetic Obese Adults
ClinicalTrials.gov study NCT06911879. IPD Sharing: NO. Countries: 1. Publications: 0.
Dietary Green Tea Confection For Resolving Gut Permeability-Induced Metabolic Endotoxemia In Obese Adults
ClinicalTrials.gov study NCT03413735. IPD Sharing: NO. Countries: 1. Publications: 2.
Alleviation Of Metabolic Endotoxemia In Adults With Metabolic Syndrome With Milk Fat Globule Membrane
ClinicalTrials.gov study NCT03860584. IPD Sharing: NO. Countries: 1. Publications: 4.
Yogurt supplementation attenuates insulin resistance in obese mice by reducing metabolic endotoxemia and inflammation
Open the record for dataset details and reuse information.
The Effect of Probiotics on Systemic Inflammation and Metabolic Endotoxemia in Patients Undergoing Bariatric Surgery
ClinicalTrials.gov study NCT05407090. IPD Sharing: NO. Countries: 1. Publications: 1.
Dietary Intervention to Reduce Metabolic Endotoxemia
ClinicalTrials.gov study NCT05776329. IPD Sharing: NO. Countries: 1. Publications: 5.
Bilberries reduce low-grade inflammation and subacute endotoxemia in individuals with features of metabolic syndrome - microarray/QPCR profiling of dietary effects of bilberries in PBMCs
GEO Series GSE34145. Homo sapiens. 60 samples. Type: Expression profiling by array; Expression profiling by RT-PCR.
The Effect of Probiotics on Obesity. Metabolic Endotoxemia and Inflammation
ClinicalTrials.gov study NCT03883685. IPD Sharing: YES. Countries: 1. Publications: 0.
Investigating the Possible Link Between Habitual Diet, Physical Activity, Sleeping Patterns, Obesity Status and Age With Gut Bacterial Composition, Gut Barrier Function, Metabolic Endotoxemia, Systemi
ClinicalTrials.gov study NCT03864107. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Cerebral Blood Flow and Metabolism During Hypoxia and Endotoxemia
ClinicalTrials.gov study NCT00332267. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effect of Gemigliptin on Metabolic Endotoxemia and Lipemia
ClinicalTrials.gov study NCT02186080. IPD Sharing: NO. Countries: 1. Publications: 0.
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