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25 results for “Microfluidic chips”
Dataset for Evaluation of a novel microfluidic chip-like device for purifying bovine frozen-thawed semen for in vitro fertilization
<p>VetCount<sup>TM</sup> Harvester (MotilityCount ApS, Copenhagen, Denmark) is a novel sperm<br> purification device. It consists of two chambers separated by a 10 μM microporous<br> membrane. Untreated semen is applied in one chamber, sperm collection medium<br> in the other. Motile sperm cells are selected by actively swimming through the<br> membrane pores into the medium containing chamber. After 30 min incubation,<br> the sperm collection medium can be aspirated and the purified sperm is ready<br> for further use.<br> In a first experiment we assessed sperm quality and recovery of frozen-thawed semen<br> from six different bulls (n = 6) prior to and after purification with the<br> VetCount<sup>TM</sup> Harvester or BoviPure<sup>TM</sup> gradient centrifugation, a commercial available standard technique. In a second approach, a competitive fertilization assay was performed. Ten straws per bull were pooled, split<br> in two subsamples, and simultaneously purified either with the VetCount<sup>TM</sup> Harvester<br> or BoviPure<sup>TM</sup> gradient centrifugation. Following purification, sperm cells<br> from each treatment group were fluorescently labeled with either MitoTracker<sup>TM</sup><br> Red FM or MitoTracker<sup>TM</sup> Green FM. <em>In vitro</em> matured oocytes were inseminated with<br> equal numbers of red and green labeled sperm. Eighteen hours after fertilization,<br> fluorescence microscopy was used to determine the origin of the fertilizing spermatozoon.</p>
Analysis of lac operon induction with single cell resolution using the DIMM microfluidics chip and the MoMA software
<p>In this work, we demonstrate the power of the DIMM (Dual Input Mother Machine), a new microfluidics setup allowing long term environmental control and single cell resolution, and MoMA (Mother Machine Analyzer), its companion image analysis sofware.</p> <p>We study the induction of the <em>lac</em> operon in <em>Escherichia coli</em> MG1655 when nutrients alternate between glucose and lactose, using a translational fusion of LacZ with GFP integrated at the endogeneous locus.</p> <p>The dataset is made of two archives:</p> <ul> <li>DIMM_MoMA_images.tar.gz contains the image data produced in this study in a form ready to be used in MoMA</li> <li>DIMM_MoMA_data.tar.gz contains textual data files produced by MoMA and its postprocessing, with the cell identifier, length and fluorescence intensity of each cell in each frame.</li> </ul> <p>Detailed instructions are provided in the ReadMe.md file (NB: this is a text file using markdown syntax, you can open it in your favorite text editor).</p>
Photoactive integrated microfluidic valves for on-chip fluid control
<p>This dataset is acompannying the publication: Photoactive integrated microfluidic valves for on-chip fluid control.</p>
The Path from Nasal Tissue to Nasal Mucosa on Chip Part 2- Advanced Microfluidic Nasal In Vitro Model for Drug Absorption Testing
<p><strong>Abstract: </strong>The nasal mucosa, being accessible and highly vascularized, opens up new opportunities for the systemic administration of drugs. However, due to several protective functions like the mucociliary clearance, this physiological barrier is a difficult obstacle for drug candidates to overcome. For this reason, effective testing procedures are required in the preclinical phase of pharmaceutical development. Based on a recently reported immortalized porcine nasal epithelial cell line, we developed a test platform based on a tissue-compatible microfluidic chip. A biomimetic glass chip equipped with a controlled bidirectional airflow to induce a physiologically relevant wall shear stress on the epithelial cell layer was microfabricated. By developing a membrane transfer technique, the epithelial cell layer could be pre-cultivated in a static holder prior to cultivation in the microfluidic environment. The dynamic cultivation within the chip showed a homogenous distribution of the mucus film on top of the cell layer and a significant increase of cilia formation compared to static cultivation condition. In addition, the recording of the ciliary transport mechanism by micro particle image velocimetry was successful. Using FITC-dextran 4000 as an example, it was shown that this nasal mucosa on a chip is suitable for permeation studies. The obtained permeation coefficient was in the range of values determined by means of other established in vitro and in vivo models. The novel nasal mucosa on chip can in future be automated and used as a substitute for animal testing.</p>
Supplementary material from: Microfluidic vessel-on-chip platform for investigation of cellular defects in venous malformations and responses to various shear stress and flow conditions
Open the record for dataset details and reuse information.
supplement videos of Solution for Mass Production of High-Throughput Digital Microfluidic Chip Based on Thin Film Transistor Technology
<p>supplement videos of Solution for Mass Production of High-Throughput Digital Microfluidic Chip Based on Thin Film Transistor Technology</p>
Microfluidic Chip Method Versus Density-gradient Centrifugation Method in IVF
ClinicalTrials.gov study NCT06005311. IPD Sharing: YES. Countries: 1. Publications: 0.
The Evaluation of the Effect of Microfluidic Sperm Sorting Chip 'Labs-on-a-chip' on IVF Success in Male Factor
ClinicalTrials.gov study NCT03960229. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Custom microfluidic chip design enables cost-effective three-dimensional spatiotemporal transcriptomics with a wide field of view
<pre>Data analysis code and preprocessed data for MAGIC-seq.</pre>
Bioengineered pancreas-liver crosstalk in a microfluidic co-culture chip identifies human metabolic response signatures in prediabetic hyperglycemia
GEO Series GSE214764. Homo sapiens. 14 samples. Type: Expression profiling by high throughput sequencing.
Cell type-specific changes in transcriptomic profiles of endothelial cells, iPSC-derived neurons and astrocytes cultured on microfluidic chips
GEO Series GSE154799. Rattus norvegicus; Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Multicellular modeling of ciliopathy by combining iPS cells and microfluidic airway-on-a-chip technology
GEO Series GSE162012. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Construction of Microfluidic Exosome Chip for Diagnosis of Lung Metastasis of Osteosarcoma
ClinicalTrials.gov study NCT05101655. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Microfluidic Chip Method Versus Density Gradient Centrifugation Method on Semen Parameters
ClinicalTrials.gov study NCT05978947. IPD Sharing: NO. Countries: 1. Publications: 0.
Microfluidic Chip vs Density Gradient Centrifugation on the Euploidy Rate of Pre-implantation Genetic Testing
ClinicalTrials.gov study NCT06023472. IPD Sharing: YES. Countries: 1. Publications: 0.
Sperm Selection and Embryo Development: Comparison of the Density Gradient Centrifugation and Microfluidic Chip Sperm Preparation Methods Sperm Selection and Embryo Development: Comparison of the Dens
ClinicalTrials.gov study NCT04962074. IPD Sharing: NO. Countries: 1. Publications: 0.
Establishment of a Microfluidic Based Liquid Biopsy Platform for Recurrent/Metastatic Head and Neck Cancers Prognostication Using NK Cell IFN-γ Expression and CTM Correlation With DS-SACA Chip
ClinicalTrials.gov study NCT06678724. IPD Sharing: YES. Countries: 1. Publications: 0.
A microfluidic bone marrow chip for the safety profiling of biologics in pre-clinical drug development
GEO Series GSE281012. Homo sapiens. 11 samples. Type: Expression profiling by high throughput sequencing.
Comparative transcriptomics of epithelial cells grown under static and microfluidic gut-on-chip conditions and benchmarked against human in vivo intestinal cells
GEO Series GSE156269. Homo sapiens. 8 samples. Type: Expression profiling by array.
Microfluidic Device Facilitates In Vitro Modeling of Human Neonatal Necrotizing Enterocolitis-on-a-Chip
GEO Series GSE226086. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.