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5 results for “Motor thalamus”
Movements during sleep reveal the developmental emergence of a cerebellar-dependent internal model in motor thalamus
<p>With our eyes closed, we can track a limb's moment-to-moment location in space. If this capacity relied on sensory feedback from the limb, we would always be a step behind because sensory feedback takes time: For the execution of rapid and precise movements, such lags are not tolerable. Nervous systems solve this problem by computing representations—or internal models—that mimic movements as they are happening, with the associated neural activity occurring after the motor command but before the sensory feedback. Research in adults indicates that the cerebellum is necessary to compute internal models. What is not known, however, is when—and under what conditions—this computational capacity develops. Here, taking advantage of the unique kinematic features of the discrete, spontaneous limb twitches that characterize active sleep, we captured the developmental emergence of a cerebellar-dependent internal model. Using rats at postnatal days (P) 12, P16, and P20, we compared neural activity in the ventral posterior (VP) and ventral lateral (VL) thalamic nuclei, both of which receive somatosensory input but only the latter of which receives cerebellar input. At all ages, twitch-related activity in VP lagged behind the movement, consistent with sensory processing; similar activity was observed in VL through P16. At P20, however, VL activity no longer lagged behind movement, but instead precisely mimicked the movement itself; this activity depended on cerebellar input. In addition to demonstrating the emergence of internal models of movement, these findings implicate twitches in their development and calibration through, at least, the preweanling period.</p>
Deep Brain Stimulation Motor Ventral Thalamus (VOP/VIM) for Restoration of Speech and Upper-limb Function in People With Subcortical Stroke
ClinicalTrials.gov study NCT06303869. IPD Sharing: YES. Countries: 1. Publications: 7.
Long-term Brain Stimulation of the Motor Ventral Thalamus (VOP/VIM) to Improve Motor Function
ClinicalTrials.gov study NCT07056348. IPD Sharing: YES. Countries: 1. Publications: 8.
Movements during sleep reveal the developmental emergence of a cerebellar-dependent internal model in motor thalamus
Open the record for dataset details and reuse information.
High-frequency stimulation of the ventrolateral thalamus regulates gene expression in hippocampus, motor cortex and caudate-putamen
GEO Series GSE25860. Rattus norvegicus. 11 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.