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56 results for “MutS”
Fig. 5 in Late Tortonian bryozoans from Mut Basin, Central Anatolian Plateau, southern Turkey
Fig. 5. Interior view of an ascophoran bryozoan Ostrovskia triforamina gen. et sp. nov. from the Miocene of Turkey. A. PM2−T1155, interior view of several zooecia showing a perforated ovicell, marginal areolar−septular pore canals in section, small pseudopores, and, in the left−hand zooecium, the interior of a triangular heterozooecium inside the peristome. B. PM2−T1157, proximal interior of a peristome with the fractured chamber of a triangular intraperistomial heterozooecium. C. PM2−T1158, detail of two broken peristomes showing triangular heterozooecium with small pores situated inside. D. PM2−T1156, oblique view of ovicell autozooecium showing perforation of ovicell and part of an intra−peristomial heterozooecium with one corner opening toward an interior areolar−septular pore. Scale bars 100 µm.
Fig. 4 in Late Tortonian bryozoans from Mut Basin, Central Anatolian Plateau, southern Turkey
Fig. 4. Exterior and interior view of an ascophoran bryozoan Ostrovskia triforamina gen. et sp. nov. from the Miocene of Turkey. A. PM2−T1245, holotype, exterior view showing arrangement of autozooecia and the broken tips of intra−peristomial heterozooecia visible on the proximal margin of the orifice, appearing as denticles. B. PM2−T1246, interior view showing immersed ovicell, marginal areolar−septular pore canals in section, perforation of frontal wall and small condyles on the sides of the orifice. C. PM2−T1247, detail of autozooecia showing ovicells with perforated endooecium and a small suboral area of imperforate frontal shield. D. PM2−T1134, detail of ovicell with entooecial perforations and, proximolateral to it on both sides, broken areolar−septular pore canals. All specimens from sample BAS 4. Scale bars A, 1 mm; B–D, 100 µm.
Fig. 3 in Late Tortonian bryozoans from Mut Basin, Central Anatolian Plateau, southern Turkey
Fig. 3. Interior view of an ascophoran bryozoan Basyaylella elsae gen. et sp. nov. from the Miocene of Turkey. A. PM2−T126, detail showing part of a concealed ovicell chamber (broken) and the reduced umbonuloid part of the frontal shield. B. PM2−T1159, autozooecial profiles with clearly observable umbonuloid part of the frontal shield, smooth peristome, large pseudopores and laminations in frontal shield. C. PM2−T1227, detail of a laterally broken specimen with well pronounced laminations in frontal shield and a smooth peristome. D. PM2−T1228, interior view showing broken, concealed ovicellular chambers, deeply immersed in distal autozooecia. E. PM2−T1229a, similar view to D and also showing the umbonuloid part of the frontal shield. F. PM2−T1160, detail of ovicell interior with entooecial perforations. A, C, D, E sample BAS 4; B, F sample BAS 7. Scale bars 100 µm.
Fig. 1 in Late Tortonian bryozoans from Mut Basin, Central Anatolian Plateau, southern Turkey
Fig. 1. Late Tortonian bryozoans from the Başyayla section. A. Exidmonea sp. (PM2−T1124) with very extended frontal gonozooecium from sample BAS 2. B–E. Biflustra savartii auctt. B. PM2−T1127, frontal view of colony, sample BAS 8. C. PM2−T1126, abfrontal view showing three rows of autozooecia with characteristic angled appearance, sample BAS 8. D. PM2−T1125, lateral view of the three autozooecia showing regularly distributed lateral communication pores, sample BAS 4. E. PM2−T1129, detail of lateral communication pores showing multiporous septula, sample BAS 4. F–H. Margaretta sp. F. PM2−T1130, external view showing concealed ovicells (visible as bulges in frontal shield), sample BAS 8. G. PM2−T1131, internal view showing peristomial chamber, with an ascopore situated in the midline of the frontal shield, sample BAS 11. H. PM2−T1132, detail of the aperture of a colony showing linear structures in the peristomial wall, sample BAS 7. I. Margaretta cereoides (Ellis and Solander, 1786) (PM2−P1939) from section Hlohovec (Moravia) showing the smooth interior surface of the peristome. Scale bars A, B, F, 1 mm; C–E, G–I, 100 µm.
The goddess Mut
The goddess Mut was done after a photographic representation of the head of the statue. The Royal Cast Collection at SMK (The National Gallery of Denmark) has owned a plaster cast of the work since 1903. The original statue, now housed at the Egyptian museum in Cairo, is a fragment of a so-called colossal statue depicting the goddess Mut. Mut was part of the 'Theban triad', a trinity of gods consisting of Amon the father, Mut the mother and Khonsu, their son. These deities gained a prominent place in Egyptian mythology when Thebes was a royal residence just around the time the statue was carved. Source: Objaverse 1.0 / Sketchfab
BELIEF (Bevacizumab and ErLotinib In EGFR Mut+ NSCLC)
ClinicalTrials.gov study NCT01562028. IPD Sharing: Not stated. Countries: 8. Publications: 4.
The Study Observes How Long Patients With Non-small Cell Lung Cancer (NSCLC) Benefit From Treatment With Epidermal Growth Factor Tyrosine Kinase Inhibitor (EGFR-TKI) When Given Either for Uncommon Mut
ClinicalTrials.gov study NCT04179890. IPD Sharing: NO. Countries: 1. Publications: 1.
Recurrent mismatch binding by MutS mobile clamps on DNA localizes repair complexes nearby
<p>DNA mismatch repair (MMR), the guardian of the genome, commences when MutS identifies a mismatch and recruits MutL to nick the error-containing strand, allowing excision and DNA resynthesis. Dominant MMR models posit that after mismatch recognition, ATP converts MutS to a hydrolysis-independent, diffusive mobile clamp that no longer recognizes the mismatch. Little is known about the postrecognition MutS mobile clamp and its interactions with MutL. Two disparate frameworks have been proposed: One in which MutS–MutL complexes remain mobile on the DNA, and one in which MutL stops MutS movement. Here we use single-molecule FRET to follow the postrecognition states of MutS and the impact of MutL on its properties. In contrast to current thinking, we find that after the initial mobile clamp formation event, MutS undergoes frequent cycles of mismatch rebinding and mobile clamp reformation without releasing DNA. Notably, ATP hydrolysis is required to alter the conformation of MutS such that it can recognize the mismatch again instead of bypassing it; thus, ATP hydrolysis licenses the MutS mobile clamp to rebind the mismatch. Moreover, interaction with MutL can both trap MutS at the mismatch en route to mobile clamp formation and stop movement of the mobile clamp on DNA. MutS's frequent rebinding of the mismatch, which increases its residence time in the vicinity of the mismatch, coupled with MutL's ability to trap MutS, should increase the probability that MutS–MutL MMR initiation complexes localize near the mismatch.</p> <p> </p>
Imatinib and Toripalimab in Patients With Locally Advanced/Metastatic Melanoma Harbored With CKIT Mut
ClinicalTrials.gov study NCT05274438. IPD Sharing: NO. Countries: 1. Publications: 1.
PD-1 Antibody Plus Bevacizumab and CAPOX as First-line Treatment for RAS-mut MSS mCRC
ClinicalTrials.gov study NCT06206096. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Recurrent mismatch binding by MutS mobile clamps on DNA localizes repair complexes nearby
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Cap analysis gene expression (CAGE) of Aspergillus luchuensis mut. kawachii control and sirtuin D disruptant strains
GEO Series GSE132729. Aspergillus luchuensis. 6 samples. Type: Expression profiling by high throughput sequencing.
MDA-MB-231 cell: infected with lentivirus to stably express mut-Elf5 vs WT-Elf5
GEO Series GSE32144. Homo sapiens. 6 samples. Type: Expression profiling by array.
ActD timecourse in HeLa cells, HeLa RNF219 KO cells, HeLa RNF219 KO cells overexpressing 3xFLAG-SBP-RNF219-WT or 3xFLAG-SBP-RNF219-mut
GEO Series GSE172019. Homo sapiens. 32 samples. Type: Expression profiling by high throughput sequencing.
FACS-sorted Six2-positive nephron progenitor cells at embryonic day 15.5: wildtype (WT) vs. conditional HDAC1&2-null (MUT)
GEO Series GSE84305. Mus musculus. 8 samples. Type: Expression profiling by array.
Analysis of gene expression changes upon ZBTB18 full length (FL), ZBTB18 full length-mutant (FL-mut), ZBTB18 short form Nte (SF-Nte) and ZBTB18 short form Nte (SF-mut) in SNB19 glioblastoma cell line
GEO Series GSE184890. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
Expression in the Mut- ko/ki (Mut p.M700K) and controls
GEO Series GSE121060. Mus musculus. 9 samples. Type: Expression profiling by array.
RNA-Seq experiments for isolated mice tissues in both WT and Mut mice
GEO Series GSE291697. Mus musculus. 32 samples. Type: Expression profiling by high throughput sequencing.
RNAseq of SEC23B wildtype (WT) and mutant (MUT) thyroid cell lines treated with Tunicamycin (Tunica, ER stress)
GEO Series GSE112661. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
Microarray expression in whole brain of Hfe-/-xTfr2mut (double mut) vs wildtype (wt) AKR mice
GEO Series GSE70431. Mus musculus. 8 samples. Type: Expression profiling by array.
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OpenNeuro
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