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35 results for “Mutational Correlation”
Synthetic mutational spectra with mixed and correlated mutational signatures SBS1 and SBS5
<p>Experience suggests that it harder to extract mutational signatures that always co-occur and that generate correlated numbers of mutations. Here we provide 12 data sets, each consisting of 500 synthetic mutational spectra with varying degrees of mixture and correlation between two mutational signatures. The signatures studied were SBS1, a "clock-like" signature due to deamination of 5-methyl cytosine that consists primarily of mutations from CG > TG, and SBS5, a relatively flat "clock-like" signature. By "clock-like" we mean that the numbers of mutations attributable to these signatures increase with patients' ages. The 12 data sets varied in two dimensions: (i) average ratio of the number of SBS1 to the number of SBS5 mutations in spectra in the data set and (ii) correlation between the number of SBS1 and the number of SBS5 mutations in spectra in the data set. The mutational signatures SBS1 and SBS5 are described at https://doi.org/10.7303/syn12025148 and https://doi.org/10.1101/322859. </p>
Datset related to article "G507D MUTATION IN FUS GENE CAUSES FAMILIAL AMYOTROPHIC LATERAL SCLEROSIS WITH A SPECIFIC GENOTYPE-PHENOTYPE CORRELATION"
<p><strong>NGS_analysis performed at Fondazione Besta carried out as part of the study reported at title</strong></p>
Dataset related to article"G507D MUTATION IN FUS GENE CAUSES FAMILIAL AMYOTROPHIC LATERAL SCLEROSIS WITH A SPECIFIC GENOTYPE-PHENOTYPE CORRELATION"
<p>NGS Analyses of patients included in the study reported at title followed at Fondazione Besta</p>
A point mutation and large deletion at the candidate avirulence locus AvrMlp7 in the poplar rust fungus correlate with poplar RMlp7 resistance breakdown
<p>Several studies reported the rapid evolution of avirulence (<i>Avr</i>) genes to escape <i>R</i>-mediated plant immunity and identified a variety of mechanisms leading to virulence. The poplar rust fungus <i>Melampsora larici-populina</i> is the most damaging pathogen of poplars. A major adaptive event occurred in 1994 with the breakdown of <i>RMlp7</i> resistance gene in poplar. Population genomics studies identified a locus in the genome of <i>M. larici-populina</i>, which likely corresponds to the <i>AvrMlp7</i> candidate avirulence gene. We used a population genetics approach combined with dedicated qPCR assays on a comprehensive set of 281 isolates, covering 27 years (encompassing the resistance breakdown event), to validate the candidate locus and to assess its polymorphism. We found two mechanisms, a point mutation and a deletion, that allowed the pathogen to escape <i>RMlp7</i>-mediated resistance. Six diploid genotypes were thus characterized at the candidate locus (three avirulent and three virulent). In addition, a temporal analysis revealed that the two virulence alleles pre-existed (harboured as avirulent heterozygous genotypes) since the early samplings and were found in association (as virulent genotypes) at the time of the resistance breakdown.These molecular analyses were complemented by a population genetic analysis of those temporal samples, using 22 microsatellite markers.</p>
Correlation between drug response and driver gene mutations
<p>Raw results of paper 'Single nucleotide and copy number variants of cancer driver genes inform drug response in multiple cancers'</p>
Phase II Trial to Correlate Radiographic Response Induced By Gefitinib With Mutations in the Protein-Tyrosine Kinase Domain of the EGF Receptor Gene
ClinicalTrials.gov study NCT00588445. IPD Sharing: Not stated. Countries: 1. Publications: 2.
A point mutation and large deletion at the candidate avirulence locus AvrMlp7 in the poplar rust fungus correlate with poplar RMlp7 resistance breakdown
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Detailed Phenotypic and Genotype Study to Correlate RB1 Mutations Relating to Primary Ocular Tumors and Secondary Extra-ocular Metastasis.
ClinicalTrials.gov study NCT06725173. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Study to Determine Mutations in the Gaucher Gene in Patients With Idiopathic Parkinson's Disease for Phenotype-genotype Correlation
ClinicalTrials.gov study NCT01272687. IPD Sharing: Not stated. Countries: 2. Publications: 13.
Non-Interventional Retrospective Correlation Of Tumor Mutational Status To Clinical Benefit Of GIST Patients Treated With Sunitinib
ClinicalTrials.gov study NCT01459757. IPD Sharing: Not stated. Countries: 16. Publications: 1.
Data from: What affects the predictability of evolutionary constraints using a G-matrix? The relative effects of modular pleiotropy and mutational correlation
Phenotypic traits do not always respond to selection independently from each other and often show correlated responses to selection. The structure of a genotype-phenotype map (GP map) determines trait covariation, which involves variation in the degree and strength of the pleiotropic effects of the underlying genes. It is still unclear, and debated, how much of that structure can be deduced from variational properties of quantitative traits that are inferred from their genetic (co)variance matrix (G-matrix). Here we aim to clarify how the extent of pleiotropy and the correlation among the pleiotropic effects of mutations differentially affect the structure of a G-matrix and our ability to detect genetic constraints from its eigen decomposition. We show that the eigenvectors of a G-matrix can be predictive of evolutionary constraints when they map to underlying pleiotropic modules with correlated mutational effects. Without mutational correlation, evolutionary constraints caused by the fitness costs associated with increased pleiotropy are harder to infer from evolutionary metrics based on a G-matrix's geometric properties because uncorrelated pleiotropic effects do not affect traits' genetic correlations. Correlational selection induces much weaker modular partitioning of traits' genetic correlations in absence then in presence of underlying modular pleiotropy.
A Study on the Correlation Between Tarceva (Erlotinib) - Induced Rash and Efficacy in EGFR Mutated Participants With Advanced Non-Small Cell Lung Cancer Receiving First-Line Therapy
ClinicalTrials.gov study NCT01174563. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: What affects the predictability of evolutionary constraints using a G-matrix? The relative effects of modular pleiotropy and mutational correlation
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Data from: Sexual selection on spontaneous mutations strengthens the between-sex genetic correlation for fitness
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Conjunctival melanoma copy number alterations and correlation with mutation status, tumor features and clinical outcome
GEO Series GSE123011. Homo sapiens. 59 samples. Type: Genome variation profiling by SNP array.
Deep mutational scanning reveals a tight correlation between protein degradation and toxicity of thousands of non-native aspartoacylase protein variants
GEO Series GSE254639. synthetic construct. 61 samples. Type: Other.
Vulnerability and life-history traits correlate with the load of deleterious mutations in fish
<p><strong>Phylogenetic dataset associated to the article : Vulnerability and life-history traits correlate with the load of deleterious mutations in fish</strong></p> <ul> <li>fastagenes.tar.gz : all the fasta file alignments used for the study.</li> <li>teleost.tr: phylogenetic tree used for mapnh et codeml analyses.</li> <li>tree-date.tr : phylogenetic tree used to control for phylogeny (tip labels corresponding to alignments).</li> <li>tree-date_spNames.tre : phylogenetic tree used to control for phylogeny (tip labels = species names).</li> <li> <p>ENSDARE00000004235_nucl.fasta.bppml_dnds: example of option file for bppml.</p> </li> <li> <p>ENSDARE00000004235_nucl.fasta.mapnhYN98: example of option file for mapnh.</p> </li> <li> <p>ENSDARE00000004235_nucl.phylip.ctl: example of control file for codeml.</p> <p> </p> <p> </p> <p> </p> </li> </ul>
Mutation of the BTK Gene and Genotype-phenotype Correlation of Chinese Patients With X-Linked Agammaglobulinemia
ClinicalTrials.gov study NCT02234791. IPD Sharing: Not stated. Countries: 1. Publications: 0.
MEVALONATE KINASE GENE MUTATIONS AND THEIR CLINICAL CORRELATIONS IN BEHÇET'S DISEASE
ClinicalTrials.gov study NCT01780363. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Genotype-phenotype Correlations in Children and Adults With CTNNB1 Mutation
ClinicalTrials.gov study NCT04812119. IPD Sharing: NO. Countries: 2. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.