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104 results for “Mycobacterium avium”
Supplementary Material to article "Molecular Diversity of Mycobacterium avium subsp. paratuberculosis in Four Dairy Goat Herds from Thuringia (Germany)"
<p>These data (supplementary material) belong to the publication "Molecular Diversity of <i>Mycobacterium avium</i> subsp. <i>paratuberculosis</i> in Four Dairy Goat Herds from Thuringia (Germany)". The study determined the diversity of <i>Mycobacterium avium</i> subsp. <i>paratuberculosis</i> (MAP) isolated from four goat herds affected by paratuberculosis in Thuringia (Germany), as well as the detailed distribution of MAP genotypes among the animals and their environment in one herd (herd 1). A combination of three methods was used to genotype isolates from fecal samples of infected goats, from various intestinal and other tissues of clinically affected goats, and from environmental samples. The six MAP-C genotypes identified could be assigned to five different phylogenetic subgroups. The results suggest individual infection strains within each herd. In herd 1, one predominant strain was found, and two strains occurred sporadically. The identified genotypes were not goat specific.</p>
Supplementary dataset to publication: Complete Genome Sequence of Ovine Mycobacterium avium subsp. paratuberculosis Strain JIII-386 (MAP-S/type III) and Its Comparison to MAP-S/type I, MAP-C, and M. avium Complex Genomes.
<p>This is the modified supplemented material to the publication “Complete genome sequence of ovine Mycobacterium avium subsp. paratuberculosis strain JIII-386 (MAP-S/type III) and its comparison to MAP-S/type I, MAP-C, and M. avium complex genomes”.</p> <p>The complete circular genome of Mycobacterium avium subsp. paratuberculosis (MAP) strain JIII-386 from Germany, closed by Nanopore technology in this study, was presented and compared with the draft genome of JIII-386, previously published in [doi:10.1093/gbe/ew154], the closed genome of the MAP-S/type I strain Telford, the MAP-S/type III draft genome of strain S397, twelve closed MAP-C (type II) strains and eight closed Mycobacterium avium (M. a.) strains of subsp. hominissuis (MAH) and subsp. avium (MAA). Structural comparisons clearly revealed the mosaic nature of MAP genomes, the differences between MAP subtypes I, II and III, and the higher diversity of MAP-S compared to MAP-C genomes. </p> <p>The material provides a wealth of detailed results from these analyses and comparisons. These include a list of identified ncRNA and Riboswitches, as well as additional genes in finished JIII-386, the gene content of identified prophage regions, copy number of identified transposable elements and a list of selected virulence-associated genes in the different MAP-type (I - III) strains. The genomic islands identified and included genes along with their predicted functions were presented for six MAP genomes (belonging to MAP-S/type I and III, and MAP-C), one MAH genome and one MAA genome. One table shows the corresponding genomic islands in the genomes of JIII-386, Telford and three MAP-C genomes. Furthermore, homologous genes of known MAP-S specific Large Sequence Polymorphisms regions (LSP<sup>S</sup> = LSP-S) were recorded in different MAP-S type strains, one MAH and one MAA strain, as well as genes of deletions #1 (LSP<sup>A</sup>-20), #2, and s-delta-1, previously described as MAP-S-specific deletions, their presence or absence in 3 MAP-S, 12 MAP-C, 4 MAH, and 4 MAA strains were listed. Different presence or absence of genes, but also identified frameshifts or disruptions of various virulence-associated genes could lead to the different MAP-type specific phenotypic characteristics. Comprehensive core and pan genome analyses (results listed in six tables) revealed unique genes and genes likely to have been acquired by horizontal gene transfer in different MAP types and subtypes, but also emphasized the highly conserved and close relationship, and the complex evolution of M. a. strains.</p> <p> </p>
Development of a spectral library for the discovery of altered genomic events in Mycobacterium avium associated with virulence using mass spectrometry-based proteogenomic analysis
<p><em>Mycobacterium avium</em> is one of the prominent disease-causing bacteria in humans. It causes lymphadenitis, chronic and extrapulmonary, and disseminated infections in adults, children, and immunocompromised patients. <em>M. avium</em> has ~4,500 predicted protein-coding regions on an average, which can be helpful in discovering several variants at the proteome level. Many of them are potentially associated with virulence, thus identifying such proteins can be a helpful feature in the development of panel-based theranostics. In line with such a long-term goal, we carried out an in-depth proteomic analysis of <em>M. avium</em> with both data-dependent and data-independent acquisition methods. Further, a set of proteogenomic investigations were carried out using the protein database for <em>Mycobacterium tuberculosis,</em> and a genome six-frame translated database and a variant protein database of <em>M. avium</em>. A search of mass spectrometry data analysis against <em>M. avium</em> protein database resulted in the identification of 2,954 proteins. Further, proteogenomic analyses aided in the identification of 1,301 novel peptide sequences and correction of translation start sites for 15 proteins. At the end, we created a spectral library of <em>M. avium</em> proteins including novel genome search-specific peptides and variant peptides detected in this study. We validated the spectral library by a data-independent acquisition of the <em>M. avium</em> proteome. Thus, we present a <em>M. avium </em>spectral library of 29,033 peptide precursors supported by 0.4 million fragment ions for further use by the biomedical community.</p>
Comparison of Two- Versus Three-antibiotic Therapy for Pulmonary Mycobacterium Avium Complex Disease
ClinicalTrials.gov study NCT03672630. IPD Sharing: YES. Countries: 2. Publications: 18.
A Study of Standard Drugs for Mycobacterium Avium Complex
ClinicalTrials.gov study NCT04287049. IPD Sharing: NO. Countries: 1. Publications: 10.
Validation of Patient Reported Outcome Measures in Participants With Nontuberculous Mycobacterial Lung Infection Caused by Mycobacterium Avium Complex
ClinicalTrials.gov study NCT04677543. IPD Sharing: NO. Countries: 12. Publications: 1.
The Safety and Effectiveness of Clarithromycin in the Prevention of Mycobacterium Avium Complex (MAC) Infection in HIV-Infected Patients
ClinicalTrials.gov study NCT00002336. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Comparison of Three Drug Combinations Containing Clarithromycin in the Treatment of Mycobacterium Avium Complex (MAC) Disease in Patients With AIDS
ClinicalTrials.gov study NCT00001058. IPD Sharing: Not stated. Countries: 2. Publications: 1.
A Phase II/III Trial of Rifampin, Ciprofloxacin, Clofazimine, Ethambutol, and Amikacin in the Treatment of Disseminated Mycobacterium Avium Infection in HIV-Infected Individuals.
ClinicalTrials.gov study NCT00000641. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Study of Four Different Treatment Approaches for Patients Who Have Mycobacterium Avium Complex Disease (MAC) Plus AIDS
ClinicalTrials.gov study NCT00001047. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of SPR720 as Compared With Placebo for the Treatment of Participants With Mycobacterium Avium Complex (MAC) Pulmonary Disea
ClinicalTrials.gov study NCT05496374. IPD Sharing: NO. Countries: 1. Publications: 0.
Study to Evaluate ALIS (Amikacin Liposome Inhalation Suspension) in Participants With Nontuberculous Mycobacterial Lung Infection Caused by Mycobacterium Avium Complex
ClinicalTrials.gov study NCT04677569. IPD Sharing: NO. Countries: 23. Publications: 0.
A Randomized, Double-Blinded, Placebo-Controlled, Phase II Inhaled Interferon Gamma-1b and Antimycobacterials to Treat Pulmonary Mycobacterium Avium Complex Infections
ClinicalTrials.gov study NCT00021567. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Adjuvant Cytokine Therapy to Treat Pulmonary Mycobacterium Avium Complex Infection
ClinicalTrials.gov study NCT00111397. IPD Sharing: Not stated. Countries: 1. Publications: 3.
The Safety and Effectiveness of Clarithromycin and Rifabutin Used Alone or in Combination to Prevent Mycobacterium Avium Complex (MAC) or Disseminated MAC Disease in HIV-Infected Patients
ClinicalTrials.gov study NCT00001030. IPD Sharing: Not stated. Countries: 2. Publications: 7.
Subcutaneously Administered Interleukin-12 Therapy in HIV-Infected Patients With Disseminated Mycobacterium Avium Complex Infection
ClinicalTrials.gov study NCT00001763. IPD Sharing: Not stated. Countries: 1. Publications: 3.
A Randomized Controlled Prophylactic Study of Clofazimine To Prevent Mycobacterium Avium Complex Infection in HIV Disease
ClinicalTrials.gov study NCT00002058. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Safety, Tolerability, Pharmacokinetics and Efficacy of SPR720 for the Treatment of Patients With Mycobacterium Avium Complex (MAC) Pulmonary Disease
ClinicalTrials.gov study NCT04553406. IPD Sharing: NO. Countries: 1. Publications: 0.
Rifabutin Therapy for the Prevention of Mycobacterium Avium Complex (MAC) Bacteremia in AIDS Patients With CD4 Counts = or < 200: A Double-Blind, Placebo-Controlled Trial
ClinicalTrials.gov study NCT00002032. IPD Sharing: Not stated. Countries: 1. Publications: 2.
The Effects of Treatment for Mycobacterium Avium Complex (MAC) on the Cells of HIV-Infected Patients
ClinicalTrials.gov study NCT00000860. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.