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19 results for “Mycobacterium intracellulare”
Data from: Bacteriophage infection and killing of intracellular Mycobacterium abscessus
<p><em>Mycobacterium</em> <em>abscessus</em> is a nontuberculous mycobacterium (NTM) that contributes to the decline and death of patients with lung diseases such as cystic fibrosis and other muco-obstructive airway diseases. <em>M. abscessus</em> is challenging to treat due to its extensive antibiotic resistance and ability to survive inside mammalian cells. An alternative to antibiotics is the therapeutic use of bacteriophages (phages). There are recent cases of phage therapy being used to treat <em>M. abscessus</em> infections in people under compassionate-use conditions. However, little is known about the ability of phages to kill bacteria, such as <em>M. abscessus</em>, that reside in an intracellular environment. Here, we used <em>M. abscessus</em> strains and phages from recent phage therapy cases to determine if phages can enter mammalian cells and if they can infect and kill intracellular <em>M. abscessus</em>. Using fluorescence microscopy, we demonstrate phage uptake by macrophages and lung epithelial cells, and we further demonstrate phage infection of intracellular <em>M. abscessus</em> with fluorescent reporter phages. Transmission electron microscopy was additionally used to image phage infection of intracellular <em>M. abscessus</em>. Together, these findings provide the first visualizations of phage-<em>M. abscessus</em> interactions in an intracellular environment. Finally, we show that phage treatment can significantly reduce the intracellular burden of <em>M. abscessus</em> in a manner that depends on both the specific phage and mammalian cell type involved. These results demonstrate the potential to use phage therapy to treat intracellular bacteria, specifically <em>M. abscessus</em>, while also highlighting the importance of prescreening phage therapy candidates for activity in an intracellular environment.</p>
Data from: Bacteriophage infection and killing of intracellular Mycobacterium abscessus
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Mass spectrometry data from: Deficiency in Galectin-3, -8, and -9 impairs immunity to chronic Mycobacterium tuberculosis infection but not acute infection with multiple intracellular pathogens
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Impaired fatty acid import and metabolism in macrophages restricts intracellular growth of Mycobacterium tuberculosis
GEO Series GSE270571. Mus musculus; Mycobacterium tuberculosis. 12 samples. Type: Expression profiling by high throughput sequencing.
Involvement of transcription elongation factor GreA in Mycobacterium tuberculosis viability, antibiotic susceptibility, and intracellular fitness
GEO Series GSE143764. Mycolicibacterium smegmatis MC2 155. 10 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
A Lysosomal In Vitro Exposure (LivE) Model to Identify Pathways Critical for Mycobacterium tuberculosis Intracellular Persistence
GEO Series GSE68337. Mycobacterium tuberculosis CDC1551. 15 samples. Type: Expression profiling by high throughput sequencing.
Mycobacterium tuberculosis Exploits a Molecular Off Switch of the Immune System for Intracellular Survival
GEO Series GSE108363. Homo sapiens. 186 samples. Type: Expression profiling by array.
The involvement of Mycobacterium type III-A CRISPR-Cas system in oxidative stress and intracellular fitness
GEO Series GSE166137. Mycobacterium tuberculosis variant bovis. 6 samples. Type: Expression profiling by high throughput sequencing.
The hsa_circ_0002371/hsa-miR-502-5p/ATG16L1 axis modulates the survival of intracellular Mycobacterium tuberculosis and autophagy in macrophages
GEO Series GSE261175. Homo sapiens. 6 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Comparative evaluation of band-based genotyping methods for Mycobacterium intracellulare and its application for epidemiological analysis
<p><em>Mycobacterium intracellulare</em> is a leading cause of nontuberculous mycobacterial pulmonary disease, with a rapidly increasing prevalence worldwide. This bacterium, commonly distributed in soil and water, is known to be transmitted through the environment rather than between people. Therefore, it is imperative to establish distinguishable genotyping methods to understand the clinical outcome, disease relapses, and epidemiology. Therefore, the present study comprised two steps. First, variable number tandem repetition (VNTR), VNTR-mycobacterial interspersed repetitive units (VNTR-MIRU), repetitive sequence based-PCR (rep-PCR) and pulsed field gel electrophoresis (PFGE) as band-based genotyping methods were performed using 19 <em>M. intracellualre</em> isolated from patients with PD. The comparative results of genotyping techniques and geographical characteristics in this study may provide fundamental information for the epidemiology of <em>M. intracellulare</em>.</p>
Mycobacterium Avium Intracellulare Complex (MAC) Study
ClinicalTrials.gov study NCT00826423. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Global gene networks of canine monocyte-derived macrophages infected with Mycobacterium intracellulare
GEO Series GSE158425. Canis lupus familiaris. 16 samples. Type: Expression profiling by high throughput sequencing.
Intracellular transcriptional adaptation of Mycobacterium tuberculosis complex (MTC) clinical isolates inside resting murine macrophages
GEO Series GSE21112. Mycobacterium tuberculosis. 34 samples. Type: Expression profiling by array.
The Intracellular Life of Mycobacterium avium subsp. paratuberculosis During Macrophage Stress: A Key Role for the Alternative Sigma Factor, SigH
GEO Series GSE43182. Mycobacterium avium subsp. paratuberculosis K-10. 4 samples. Type: Expression profiling by high throughput sequencing.
Intracellular transcriptional adaptation of Mycobacterium tuberculosis complex (MTC) clinical isolates inside activated murine macrophages
GEO Series GSE21113. Mycobacterium tuberculosis. 34 samples. Type: Expression profiling by array.
Evaluation of the Therapeutic Benefit of r-metHuIFN- Gamma in AIDS Patients With Disseminated Mycobacterium Avium-Intracellulare (MAI) Infection: A Multi-Centered Pilot Study
ClinicalTrials.gov study NCT00002037. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Clofazamine for the Treatment of Mycobacterium Avium Intracellulare(MAI)
ClinicalTrials.gov study NCT00652067. IPD Sharing: Not stated. Countries: 0. Publications: 0.
An Open, Multicenter, Randomized, Dose-Ranging Study of Azithromycin in the Treatment of Disseminated Mycobacterium Avium-Intracellulare Complex Infection (MAC) in Patients With Acquired Immune Defici
ClinicalTrials.gov study NCT00002090. IPD Sharing: Not stated. Countries: 1. Publications: 0.
An Open-Label Study of the Use of Azithromycin in Patients With Symptomatic Disseminated Mycobacterium Avium-Intracellulare Complex (MAC) Infection Failing Current Therapy
ClinicalTrials.gov study NCT00002089. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.