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94 results for “Mycoplasma”
Lipidomic Data of Mycoplasma mycoides and JCVI-Syn3A grown on defined lipid diets
<p>Shotgun Lipidomics of four conditions: Mycoplasma mycoides grown on a 2FA + Cholesterol diet, a POPC + Cholesterol diet, a Diether PC + Cholesterol diet, and JCVI-Syn3A grown on a Diether PC + Cholesterol diet. All data made with three biological replicates. Lipids extracted from cells using the Bligh-Dyer protocol. Lipids analyzed by Lipotype with mass spectrometry based analysis. </p>
Characterisation and comparison of Mycoplasma bovis strain types from Irish and Scottish bovine isolates in a global context - code and datasets.
<p>The objectives of this paper were to firstly, characterise the strains and genetic diversity within isolates of Mycoplasma bovis collected from clinical samples of bovine respiratory disease in Ireland and Scotland, and secondly, to provide a global phylogenetic context to these isolates. </p> <p>This archive contains associated Jupyter notebooks and metadata used in the analysis for the study.</p>
Fig. 1 in Apparent effect of chronic Plasmodium infections on disease severity caused by experimental infections with Mycoplasma gallisepticum in house finches
Fig. 1. Mean severity of eye lesions ± SE (circles), and M. gallisepticum-load (log (qPCR+1)) (triangles) of birds infected through horizontal transmission with the CA2015 strain of M. gallisepticum. Birds in which Plasmodium was detected by PCR (grey symbols) developed more severe disease than birds in which Plasmodium was not found (white symbol). As there is no significant interaction between M. gallisepticum ‾strain and Plasmodium infection (Table 2) the results for the other M. gallisepticum strains are qualitatively similar and therefore not shown.
Comparative genomic analysis identifies potential adaptive variation in Mycoplasma ovipneumoniae
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First detection of herpesvirus and mycoplasma in free-ranging Hermann's tortoises (Testudo hermanni), and in potential pet vectors
<p>Two types of pathogens cause highly contagious upper respiratory tract diseases (URTD) in Chelonians: testudinid herpesviruses (TeHV) and a mycoplasma (<em>Mycoplasma agassizii</em>). In captivity, these infections are frequent and can provoke outbreaks. Pet trade generates international flow of tortoises, often without sanitary checking; individuals intentionally or accidentally released in the wild may spread pathogens. A better understanding of the transmission of infectious agents from captivity to wild tortoises is needed. Many exotic individuals have been introduced in populations of the endangered western Hermann’s tortoise (<em>Testudo hermanni hermanni</em>), notably spur-thighed tortoises (<em>Testudo graeca</em>). We assessed the presence of TeHV and mycoplasma in native western Hermann’s tortoises and in potential pet vectors in south-eastern France. Using a large sample (N=572 tortoises), this study revealed the worrying presence of herpesvirus in 7 free-ranging individuals (3 sub-populations). Additionally, <em>Mycoplasma agassizii</em> was detected in 15 of the 18 populations sampled with a frequency ranging from 2.5 to 25%. Exotic spur-thighed tortoises showed high frequency of <em>Mycoplasma </em>infection in captivity (18%) and in individuals (50%) found in native Hermann’s tortoise sub-populations, suggesting that this species could be a significant vector. The paucity of information of TeHV on European tortoise’ URTD in natural settings, especially in combination with mycoplasma, prompts for further studies. Indeed, sick tortoises remain concealed and may not be easily detected in the field. Our results indicate that both the prevalence and health impact of URTD are high should be scrutinized in the field.</p>
STI IN TIMES OF PREP: HIGH PREVALENCE OF CHLAMYDIA, GONORRHOEA, AND MYCOPLASMA AT DIF-FERENT ANATOMIC SITES IN MEN WHO HAVE SEX WITH MEN IN GERMANY
<p><strong>Background</strong>: Men who have sex with men (MSM) are disproportionally affected by sexually transmitted infections (STI). STI are often extragenital and asymptomatic. Both can delay diagnosis and treatment. HIV-positive (HIV+) MSM often show higher STI-prevalence than HIV-negative MSM (HIV-). Approval of HIV pre-exposure prophylaxis (PrEP) might have influenced sexual behaviour and STI-prevalence of HIV- MSM. We estimated STI-prevalence and risk factors amongst HIV- and HIV+ MSM in Germany to plan effective interventions.</p> <p><strong>Methods</strong>: We conducted a nationwide, cross-sectional study between 2/2018-7/2018. Thirteen MSM-friendly STI-practices screened MSM for <em>Chlamydia trachomatis (CT)</em>, <em>Mycoplasma genitalium</em> (MG), <em>Neisseria gonorrhea (NG)</em>, and <em>Trichomonas vaginalis</em> (TV) using self-collected rectal and pharyngeal swabs, and urine samples. APTIMA<sup>TM</sup> STI-assays (Hologic<sup>TM</sup> Inc., San Diego, USA) were used for diagnostics, and samples were not pooled. We collected information on socio-demographics, HIV-status, clinical symptoms, sexual behaviour within the last 6 months, and PrEP-use. We combined HIV status and PrEP use for defining risk groups, and used multivariate logistic regression to identify risk factors for STI.</p> <p><strong>Results</strong>: 2,303 MSM were included: 50.5% HIV+, median age 39 [18-79] years. Median number of male sex partners within the last six months was 5. Unprotected anal intercourse (active and/or passive, UAI) was reported by 73.2%, 43.5% use of party drugs. 78.9% had a STI history, 32.1% of STI+ MSM reported STI-related symptoms. 27.6% of HIV- MSM used PrEP.</p> <p>Overall STI-prevalence was 30,1%, and 25.0% in HIV-/PrEP- MSM (CT:7.2%; MG:14.2%; NG:7.4%; TV:0%), 40.3% in HIV-/PrEP+ MSM (CT:13.8%; MG:19.4%; NG:14.8%; TV:0.4%), and 30.8% in HIV+ MSM (CT:10.1%; MG:18.4%; NG:8.6%; TV:0.1%).</p> <p>Independent risk factors were HIV/PrEP-status (HIV-/PrEP+ OR:1.4; 95%-CI:1.0-2.0; HIV+ OR:1.5; 95%-CI:1.1-1.9), >5 sex partners (OR:1.5; 95%-CI:1.2-1.9), UAI (OR:1.9; 95%-CI:1.5-2.6), and use of party drugs (OR:1.5; 95%-CI:1.2-2.0).</p> <p><strong>Conclusions</strong>: We found a high STI-prevalence in MSM in Germany, especially in PrEP users, frequently being asymptomatic. Higher STI prevalence in PrEP users than in HIV+ MSM was partly explained by differences in risk behaviour. As a relevant proportion of PrEP users will not use a condom, counselling and comprehensive STI screening is essential and should be low threshold and preferably free of cost. Counselling of PrEP users should also address use of party drugs.</p>
Mycoplasma Genitalium Antibiotic Susceptibility and Treatment (MEGA)
ClinicalTrials.gov study NCT00358462. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Nucleotide alignment and phylogenetic tree illustrating tick-derived Mycoplasma cynos
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Data from: Epidemiological relationship between Mycoplasma pneumoniae pneumonia and recurrent wheezing episode in children: an observational study at a single hospital in Korea
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Data from: Innovative methodology for antimicrobial susceptibility determination in Mycoplasma biofilms
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Molecular prevalence of Bartonella, Babesia, and hemotropic Mycoplasma species in dogs with hemangiosarcoma from across the United States
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Data from: Phylogeny of Mycoplasma bovis isolates from Hungary based on multi locus sequence typing and multiple-locus variable-number tandem repeat analysis
Background: Mycoplasma bovis is an important pathogen causing pneumonia, mastitis and arthritis in cattle worldwide. As this agent is primarily transmitted by direct contact and spread through animal movements, efficient genotyping systems are essential for the monitoring of the disease and for epidemiological investigations. The aim of this study was to compare and evaluate the multi locus sequence typing (MLST) and the multiple-locus variable-number tandem-repeat (VNTR) analysis (MLVA) through the genetic characterization of M. bovis isolates from Hungary. Results: Thirty one Hungarian M. bovis isolates grouped into two clades by MLST. Two strains had the same sequence type (ST) as reference strain PG45, while the other twenty nine Hungarian isolates formed a novel clade comprising five subclades. Isolates originating from the same herds had the same STs except for one case. The same isolates formed two main clades and several subclades and branches by MLVA. One clade contained the reference strain PG45 and three isolates, while the other main clade comprised the rest of the strains. Within-herd strain divergence was also detected by MLVA. Little congruence was found between the results of the two typing systems. Conclusions: MLST is generally considered an intermediate scale typing method and it was found to be discriminatory among the Hungarian M. bovis isolates. MLVA proved to be an appropriate fine scale typing tool for M. bovis as this method was able to distinguish closely related strains isolated from the same farm. We recommend the combined use of the two methods for the genotyping of M. bovis isolates. Strains have to be characterized first by MLST followed by the fine scale typing of identical STs with MLVA.
Streptococcus Pneumoniae ST556 Vs Mycoplasma Pneumoniae M129 genome by Blastn analysis
<p><strong>Introduction:</strong> The overlap between Streptococcus pneumoniae and Mycoplasma pneumoniae genome was studied by Blastn analysis. Mycoplasma is an intracellular pathogen causing pneumonia with staccato cough, predominantly handled by T cell immunity. </p><p><strong>Methods:</strong> Through the NCBI website, the overlap of genome sequences of Streptococcus pneumoniae Taiwan (PT 306), and mycoplasma pneumoniae were studied using Blastn. The accession number for the Streptococcus pneumoniae ST556 was CP003357, and the Mycoplasma pneumoniae strain M129 was U00089, respectively. DNA alignments and nucleotide overlapping alignment sequences were studied.</p><p><strong>Results:</strong> There were significant overlaps between the genome sequences of these two organisms by blastn. The overlapping sequences and dot analysis are shown in the files attached in this accompanying document. The overlapping nucleotides involved with high significance (expect values = 0.0).</p><p><strong>Conclusion:</strong> There are overlaps in genome sequences between Streptococcus pneumoniae and mycoplasma genomes. Further studies are required to study the significance of the COVID-19 context and the recent outbreak of mycoplasma in the community across various countries. The overlap can throw some ideas of the use of the potential of streptococcus pneumoniae vaccines for prevention. If not a prevention Streptococcus pneumonia vaccinations can facilitate a deceleration in the spread of mycoplasma infections.</p><p> </p>
Clinical data of patients and values of antibodies in the IgM, IgA and IgG classess against Mycoplasma pneumoniae
<p><span>Data on <em>Mycoplasma pneumoniae</em> infections during last years are very limited. In this manuscript, we presented the assessment of the seroprevalence of antibodies against <em>Mycoplasma pneumoniae</em> in the numerous group of patients, as well as clinical aspects of the differential diagnostics of respiratory tract infections.</span></p>
Data from: Ultrafast evolution and loss of CRISPRs following a host shift in a novel wildlife pathogen, Mycoplasma gallisepticum
Measureable rates of genome evolution are well documented in human pathogens but are less well understood in bacterial pathogens in the wild, particularly during and after host switches. Mycoplasma gallisepticum (MG) is a pathogenic bacterium that has evolved predominantly in poultry and recently jumped to wild house finches (Carpodacus mexicanus), a common North American songbird. For the first time we characterize the genome and measure rates of genome evolution in House Finch isolates of MG, as well as in poultry outgroups. Using whole genome sequences of 12 House Finch isolates across a 13-year serial sample and an additional four newly sequenced poultry strains, we estimate a nucleotide diversity in House Finch isolates of only ~2% of ancestral poultry strains and a nucleotide substitution rate of 0.8 – 1.2 X 10-5 per site per year both in poultry and in House Finches, an exceptionally fast rate rivaling some of the highest estimates reported thus far for bacteria. We also found high diversity and complete turnover of CRISPR arrays in poultry MG strains prior to the switch to the House Finch host, but after the invasion of House Finches, there is progressive loss of CRISPR repeat diversity, and recruitment of novel CRISPR repeats ceases. Recent (2007) House Finch MG strains retain only ~50% of the CRISPR repertoire founding (1994-95) strains and have lost the CRISPR-associated genes required for CRISPR function. Our results suggest that genome evolution in bacterial pathogens of wild birds can be extremely rapid and in this case is accompanied by apparent functional loss of CRISPRs.
Evaluation of a Serology Diagnostic Kit for the Detection of Genital Mycoplasma in Pregnancy
ClinicalTrials.gov study NCT01281319. IPD Sharing: Not stated. Countries: 1. Publications: 3.
National Observatory of Mycoplasma Infections in Children Under 18 Ages in France
ClinicalTrials.gov study NCT06260371. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Trial of Placebo Versus Macrolide for Mycoplasma Pneumoniae Childhood Pneumonia: MYTHIC Study
ClinicalTrials.gov study NCT06325293. IPD Sharing: NO. Countries: 1. Publications: 9.
Methylprednisolone for Children With Severe Mycoplasma Pneumoniae Pneumonia (MCMP)
ClinicalTrials.gov study NCT02303587. IPD Sharing: NO. Countries: 1. Publications: 8.
Prospective, Monocentric, Interventional Study on Spontaneous Vaginal Clearance of Mycoplasma Genitalium
ClinicalTrials.gov study NCT04841408. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.