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11 results for “Myeloperoxidase”
Myeloperoxidase can differentiate between sepsis and non-infectious SIRS and predicts mortality in intensive care patients with SIRS.
<p>Dataset of "Myeloperoxidase can differentiate between sepsis and non-infectious SIRS and predicts mortality in intensive care patients with SIRS."</p>
Flow Cytometric Analysis of Peripheral Blood Neutrophil Myeloperoxidase Expression and Myelodysplastic Syndromes
ClinicalTrials.gov study NCT03363399. IPD Sharing: YES. Countries: 1. Publications: 2.
Flow Cytometric Analysis of Peripheral Blood Neutrophil Myeloperoxidase Expression for Ruling Out Myelodysplastic Syndromes: Protocol for a Diagnostic Accuracy Study
ClinicalTrials.gov study NCT05175469. IPD Sharing: YES. Countries: 1. Publications: 1.
Development and Prospective Validation of a Standardized Flow Cytometric Assay of Peripheral Blood Neutrophil Myeloperoxidase Expression for Ruling Out Myelodysplastic Syndromes.
ClinicalTrials.gov study NCT04399018. IPD Sharing: YES. Countries: 1. Publications: 2.
Data from: Myeloperoxidase oxidation of methionine associates with early cystic fibrosis lung disease
Open the record for dataset details and reuse information.
Dataset related to: Characterization of a Rat Model of Myeloperoxidase-Anti-Neutrophil Cytoplasmic Antibody-Associated Crescentic Glomerulonephritis
<p><strong>Background/aim: </strong> Necrotizing crescentic glomerulonephritis (GN) associated with anti-neutrophil cytoplasmic antibodies (ANCA) against myeloperoxidase (MPO) is a devastating disease that quickly progresses to kidney failure. Current therapies are broadly immunosuppressive and associated with adverse effects. We wanted to set up a model that could be suitable for testing narrowly targeted therapies.</p> <p><strong>Methods: </strong> The model was constructed in male Wistar Kyoto rats through injections of human MPO (hMPO) and pertussis toxin, followed by a sub-nephritogenic dose of sheep anti-rat glomerular basement membrane (GBM) serum to boost the disease. Rats were monitored for 35 days. Rats given hMPO alone, saline, or human serum albumin with or without anti-GBM serum were also studied.</p> <p><strong>Results: </strong> Rats receiving hMPO developed circulating anti-hMPO and anti-rat MPO antibodies. Challenging hMPO-immunized rats with the anti-GBM serum led to more glomerular neutrophil infiltration and MPO release, and severe haematuria, heavy proteinuria, and higher blood urea nitrogen than hMPO alone. Pauci-immune GN developed with crescents, affecting 25% of glomeruli. The majority of crescents were fibrocellular. Necrotizing lesions and Bowman capsule ruptures were detected. Cells double positive for claudin-1 (a marker of parietal epithelial cells [PECs]) and neural cell adhesion molecule (NCAM; progenitor PECs) were present in crescents. Double staining for NCAM and Ki-67 established proliferative status of progenitor PECs. Podocyte damage was associated with endothelial and GBM changes by electron microscopy. Monocyte/macrophages and CD4+ and CD8+ T cells accumulated in glomeruli and the surrounding area and in the tubulointerstitium. Lung haemorrhage also manifested.</p> <p><strong>Conclusion: </strong> This model reflects histological lesions of human ANCA-associated rapidly progressive GN and may be useful for investigating new therapies.</p>
Evaluating of Role of Myeloperoxidase in Prediction of Outcomes of Cardiac Surgery Procedures.
ClinicalTrials.gov study NCT03786965. IPD Sharing: NO. Countries: 1. Publications: 0.
Myeloperoxidase (MPO) Inhibitor A_Zeneca for Heart Failure With Preserved Ejection Fraction (HFpEF)
ClinicalTrials.gov study NCT03611153. IPD Sharing: NO. Countries: 1. Publications: 0.
Myeloperoxidase and Multi-Markers In the Diagnosis of Diagnoses of Acute Coronary Syndrome (MIDAS) - Sample Procurement
ClinicalTrials.gov study NCT00415948. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Plasma Myeloperoxidase Levels in Patients With Coronary Artery Disease
ClinicalTrials.gov study NCT01239979. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effect of Adjunctive Use of Vitamin B3 and B9 on Myeloperoxidase Level in the GCF of Patients With Stage I and II Periodontitis
ClinicalTrials.gov study NCT05435378. IPD Sharing: NO. Countries: 0. Publications: 0.
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