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144
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Dataset results
144 results for “Myocarditis”
Data from: Major group-B enterovirus populations deleted in the noncoding 5' region of genomic RNA modulate activation of the type I interferon pathway in cardiomyocytes and induce myocarditis
<p>Major 5'-terminally deleted (5'TD) RNA forms of group-B coxsackievirus (CVB-5'TD) has been associated with myocarditis in both mice and humans. Although it is known that interferon-β (IFN-β) signaling is critical for an efficient innate immune response against CVB-induced myocarditis, the link between CVB-5'TD RNA forms and type I IFN signaling in cardiomyocytes remains to be explored. In a mouse model of CVB3/28-induced myocarditis, major early-emerging forms of CVB-5'TD RNA have been characterized as replicative viral populations that impair IFN-β production in the heart. Synthetic CVB3/28 RNA forms mimicking each of these major 5'TD virus populations were transfected in mice and have been shown to modulate innate immune responses in the heart and to induce myocarditis in mice. Remarkably, transfection of synthetic viral RNA with deletions in the secondary structures of the 5'-terminal CVB3 RNA domain I, modifying stem-loops "b", "c" or "d", were found to impair IFN-β production in human cardiomyocytes. In addition, the activation of innate immune response by Poly(I:C), was found to restore IFN-β production and to reduce the burden of CVB-5'TD RNA-forms in cardiac tissues, thereby reducing the mortality rate of infected mice. Overall, our results indicate that major early-emerging CVB3 populations deleted in the domain I of genomic RNA, in the 5' noncoding region, modulate the activation of the type I IFN pathway in cardiomyocytes and induce myocarditis in mice. These findings shed new light on the role of replicative CVB-5'TD RNA forms as key pathophysiological factors in CVB-induced human myocarditis.</p>
Raw Data for the article: Usefulness of longitudinal systolic strain and delayed enhancement cardiac magnetic resonance in depicting risk of supraventricular arrythmias in patients with acute myocarditis and preserved left ventricular function
<p><strong>Background: </strong>Myocarditis have variable clinical presentation, evolution and prognosis. Aim of our study was to evaluate the value of speckle tracking echocardiography and cardiac magnetic resonance (CMR) in the short-term prediction of supraventricular arrhythmias (SVA) in patients with acute myocarditis.</p> <p><strong>Methods: </strong>Seventy patients (mean age 31±14 years old) with acute myocarditis and preserved left ventricular ejection fraction (LVEF) were enrolled. Longitudinal systolic strain (LS) of the left ventricle (LV), mechanical dispersion (MD) and CMR with quantitative measurement of delayed enhancement (DE) were performed in a subset of 43 patients. Logistic regression and ROC analysis were used to identify predictors of SVA RESULTS: Only LS measured at sup-epicardial, mid-wall and sub-endocardial level of the apical 4-chamber view was significantly lower in patients with SVA, while MD was marginally prolonged in this setting. A value of LS > - 16.1% measured at LV mid-wall in the apical 4-chamber view (ROC-AUC .75, Sensitivity 63%, Specificity 85%) was the most accurate measure to identify patients with SVA. DE mass was also helpful with a ROC-AUC .76; a DE-Mass > 18.9 gr. had a Sensitivity 63% and a Specificity 77%, to identify patients at risk of SVA.</p> <p><strong>Conclusions: </strong>Both DE mass and LS were associated with higher risk of SVA in patients with acute myocarditis and preserved LVEF. However, LS measured at the mid-wall level and limited to LV segments included in the apical 4-chamber view was the most accurate measure and did not show interaction with DE mass.</p>
Impact of CardiolRx on Myocardial Recovery in Patients With Acute Myocarditis
ClinicalTrials.gov study NCT05180240. IPD Sharing: NO. Countries: 5. Publications: 1.
Effects of Abatacept on Myocarditis in Rheumatoid Arthritis
ClinicalTrials.gov study NCT03619876. IPD Sharing: Not stated. Countries: 1. Publications: 14.
AbataCept for the Treatment of Immune-cHeckpoint Inhibitors Induced mYocarditiS
ClinicalTrials.gov study NCT05195645. IPD Sharing: YES. Countries: 1. Publications: 1.
Data from: Major group-B enterovirus populations deleted in the noncoding 5' region of genomic RNA modulate activation of the type I interferon pathway in cardiomyocytes and induce myocarditis
Open the record for dataset details and reuse information.
Myocarditis Causing Premature Ventricular Contractions:Insights From the MAVERIC Registry
ClinicalTrials.gov study NCT05158751. IPD Sharing: Not stated. Countries: 1. Publications: 30.
Colchicine Versus Placebo in Acute Myocarditis Patients
ClinicalTrials.gov study NCT05855746. IPD Sharing: NO. Countries: 1. Publications: 5.
Myocarditis After SARS-CoV2-Vaccination
ClinicalTrials.gov study NCT05268458. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Descriptive and Retrospective Analysis of Acute Myocarditis Associated With Pandemic COVID-19 in Children
ClinicalTrials.gov study NCT04420468. IPD Sharing: NO. Countries: 1. Publications: 3.
Acute Myocarditis Registry With Prognostic, Histologic, Immunologic, Biological, Imaging and Clinical Assessment
ClinicalTrials.gov study NCT04844151. IPD Sharing: UNDECIDED. Countries: 1. Publications: 23.
MYTHS - MYocarditis THerapy With Steroids
ClinicalTrials.gov study NCT05150704. IPD Sharing: NO. Countries: 9. Publications: 9.
Cardiovascular Imaging in Pediatric Myocarditis
ClinicalTrials.gov study NCT06652399. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
Abatacept in Immune Checkpoint Inhibitor Myocarditis
ClinicalTrials.gov study NCT05335928. IPD Sharing: NO. Countries: 2. Publications: 1.
Image-Based Prediction of Ventricular Tachycardias in Post-Myocarditis Patients: an International Multicenter Case-control Study
ClinicalTrials.gov study NCT06730607. IPD Sharing: NO. Countries: 2. Publications: 4.
Clinical, Morphological and Functional Aspects in Myocarditis.
ClinicalTrials.gov study NCT04217876. IPD Sharing: NO. Countries: 1. Publications: 11.
Ventricular Arrhythmia After Myocarditis in Sportsman
ClinicalTrials.gov study NCT03842592. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
The Role of Electrocardiograms in Risk Stratification and Analysis of the Characteristics of ST Elevation in Acute Myocarditis: a 2-centre Study
ClinicalTrials.gov study NCT04498494. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Anakinra Versus Placebo for the Treatment of Acute MyocarditIS
ClinicalTrials.gov study NCT03018834. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Occurrence, Trends, Management and Outcomes of Patients Hospitalized With Myocarditis
ClinicalTrials.gov study NCT04827706. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
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International Brain Laboratory public data
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OpenNeuro
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