Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
454
datasets available to search
ShareScore release 0.9.0
Dataset results
454 results for “NASH”
Data from: "Alteration of the gut microbiota's composition and metabolic output correlates with COVID-19-like severity in obese NASH hamsters"
<p>This dataset contains all data collected and used for the publication : "Alteration of the gut microbiota’s composition and metabolic output correlates with COVID-19-like severity in obese NASH hamsters". Besides the Readme, it contains 11 files.</p> <p><br> Excel files with classification (i.e. genes according to their fold induction or repression) are provided. Data include different conditions with varying number of samples per group. Data are structured according to employed methods and then stratify the data obtained within the individual work packages.</p>
Nash's Field grassland experiment Silwood Park, UK
<p>Nash's Field is one of the field experiments of Imperial College London, Silwood Park campus and is part of The Ecological Continuity Trust (<a href="https://www.ecologicalcontinuitytrust.org/" target="_blank" rel="noopener">ECT</a>). The experiment is a long-term study that aims to understand the degree to which nutrients, soil acidity and herbivory affect grassland ecology. It is a five-factor factorial experiment replicated in two blocks of plots using a split-plot design in a neutral grassland (MG5 Cynosurus cristatus/Centaurea debeauxii, under the UK National Vegetation Classification system). Overall, the experiment contains 8 invertebrate exclusion plots (± insects and ± molluscs, 22 x 44 m), 16 vertebrate exclusion plots (± rabbits, 22 x 22 m), 32 soil acidity plots (high vs low pH, 8 x 18 m), 96 plant competition plots (± grasses, ± herbs, 6 x 8 m) and 1,152 fertilization plots (12 combinations of N, P, K and Mg, 2 x 2 m). Except for herbicides, which were used only at the start of the experiment, all treatments have been applied continuously since 1992. Data of aboveground biomass or coverage per plant species of all herbaceous plants present has been collected annually for several years from 1992.</p>
Brachiaria platyphylla (Munro ex C.Wright) Nash (BR0000011475835)
Belgium Herbarium image of <a href="https://www.plantentuinmeise.be">Meise Botanic Garden</a>.
Brachiaria platyphylla (Munro ex C.Wright) Nash (BR0000011475507)
Belgium Herbarium image of <a href="https://www.plantentuinmeise.be">Meise Botanic Garden</a>.
Brachiaria platyphylla (Munro ex C.Wright) Nash (BR0000011475026)
Belgium Herbarium image of <a href="https://www.plantentuinmeise.be">Meise Botanic Garden</a>.
Brachiaria platyphylla (Munro ex C.Wright) Nash (BR0000011475590)
Belgium Herbarium image of <a href="https://www.plantentuinmeise.be">Meise Botanic Garden</a>.
Brachiaria platyphylla (Munro ex C.Wright) Nash (BR0000011475927)
Belgium Herbarium image of <a href="https://www.plantentuinmeise.be">Meise Botanic Garden</a>.
Brachiaria platyphylla (Munro ex C.Wright) Nash (BR0000011475170)
Belgium Herbarium image of <a href="https://www.plantentuinmeise.be">Meise Botanic Garden</a>.
Brachiaria platyphylla (Munro ex C.Wright) Nash (BR0000011476160)
Belgium Herbarium image of <a href="https://www.plantentuinmeise.be">Meise Botanic Garden</a>.
Brachiaria platyphylla (Munro ex C.Wright) Nash (BR0000012635238)
Belgium Herbarium image of <a href="https://www.plantentuinmeise.be">Meise Botanic Garden</a>.
Study of Safety, Tolerability, and Efficacy of a Combination Treatment of LJN452 and CVC in Adult Patients With NASH and Liver Fibrosis
ClinicalTrials.gov study NCT03517540. IPD Sharing: UNDECIDED. Countries: 17. Publications: 2.
Study of Various Treatments in Non-alcoholic Fatty Liver Disease (NAFLD) Patients Who Have Aspects of Non-alcoholic Steatohepatitis (NASH)
ClinicalTrials.gov study NCT04147195. IPD Sharing: YES. Countries: 3. Publications: 1.
Study of Safety and Efficacy of Tropifexor (LJN452) in Patients With Non-alcoholic Steatohepatitis (NASH)
ClinicalTrials.gov study NCT02855164. IPD Sharing: UNDECIDED. Countries: 17. Publications: 2.
Diet-induced obesity and NASH impair disease recovery in SARS-CoV-2-infected golden hamsters
<p>Obese patients with nonalcoholic steatohepatitis (NASH) are prone to severe forms of COVID-19. There is an urgent need for new treatments that lower the severity of COVID-19 in this vulnerable population. To better replicate the human context, we set up a diet-induced model of obesity associated with dyslipidemia and NASH in the golden hamster (known to be a relevant preclinical model of COVID-19). A 20-week, free-choice diet induces obesity, dyslipidemia and NASH (liver inflammation and fibrosis) in golden hamsters. Obese NASH hamsters have higher blood and pulmonary levels of inflammatory cytokines. In the early stages of a SARS-CoV-2 infection, the lung viral load and inflammation levels were similar in lean hamsters and obese NASH hamsters. However, obese NASH hamsters showed worse recovery (i.e. less resolution of lung inflammation 10 days post-infection (dpi), and lower body weight recovery on dpi 25). Obese NASH hamsters also exhibited higher levels of pulmonary fibrosis on dpi 25. Unlike lean animals, obese NASH hamsters infected with SARS-CoV-2 presented long-lasting dyslipidemia and systemic inflammation. Relative to lean controls, obese NASH hamsters had lower serum levels of angiotensin-converting enzyme 2 activity and higher serum levels of angiotensin II - a component known to favor inflammation and fibrosis. Even though the SARS-CoV-2 infection resulted in early weight loss and incomplete body weight recovery, obese NASH hamsters showed sustained liver steatosis, inflammation, hepatocyte ballooning, and marked liver fibrosis on dpi 25.<strong> </strong>We conclude that diet-induced obesity and NASH impair disease recovery in SARS-CoV-2-infected hamsters. This model might be of value in characterizing the pathophysiologic mechanisms of COVID-19 and in evaluating the efficacy of treatments for the severe forms of COVID-19 observed in obese patients with NASH.</p>
A Study of Tirzepatide (LY3298176) in Participants With Nonalcoholic Steatohepatitis (NASH)
ClinicalTrials.gov study NCT04166773. IPD Sharing: YES. Countries: 10. Publications: 1.
University of Texas H.S.C. San Antonio Pioglitazone in Non-Alcoholic Steatohepatitis Trial (UTHSCSA NASH Trial)
ClinicalTrials.gov study NCT00994682. IPD Sharing: Not stated. Countries: 1. Publications: 3.
A Study to Test Safety and Efficacy of Survodutide (BI456906) in Adults With Non-alcoholic Steatohepatitis (NASH) and Fibrosis (F1-F3)
ClinicalTrials.gov study NCT04771273. IPD Sharing: YES. Countries: 25. Publications: 1.
Safety, Tolerability, and Efficacy of Selonsertib, Firsocostat, and Cilofexor in Adults With Nonalcoholic Steatohepatitis (NASH)
ClinicalTrials.gov study NCT02781584. IPD Sharing: NO. Countries: 2. Publications: 2.
A Multiple Ascending Dose Study of Pegozafermin in Participants With Biopsy Confirmed Nonalcoholic Steatohepatitis (NASH) or Nonalcoholic Fatty Liver Disease (NAFLD) and at High Risk of NASH
ClinicalTrials.gov study NCT04048135. IPD Sharing: UNDECIDED. Countries: 2. Publications: 3.
Volixibat (SHP626) in the Treatment of Adults With Nonalcoholic Steatohepatitis (NASH)
ClinicalTrials.gov study NCT02787304. IPD Sharing: Not stated. Countries: 4. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.