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298 results for “NF-κB”
Damaged mitochondria recruit the effector NEMO to activate NF-κB signaling
<p>Failure to clear damaged mitochondria via mitophagy disrupts physiological function and may initiate damage signaling via inflammatory cascades, though how these pathways intersect remains unclear. We discovered that NF-κB essential regulator NEMO is recruited to damaged mitochondria in a Parkin-dependent manner in a time-course similar to recruitment of the structurally-related mitophagy adaptor, OPTN. Upon recruitment, NEMO partitions into phase-separated condensates distinct from OPTN, but colocalizing with p62/SQSTM1. NEMO recruitment in turn recruits the active catalytic IKK component phospho-IKKb, initiating NF-κB signaling and the upregulation of inflammatory cytokines. Consistent with a potential neuroinflammatory role, NEMO is recruited to mitochondria in primary astrocytes upon oxidative stress. These findings suggest that damaged, ubiquitinated mitochondria serve as an intracellular platform to initiate innate immune signaling, promoting the formation of activated IKK complexes sufficient to activate NF-kB signaling. We propose that mitophagy and NF-κB signaling are initiated as parallel pathways in response to mitochondrial stress. </p>
Data from: LAR1 activates NF-κB signaling pathway by binding to APOC1 mRNA and enhancing its expression: A novel mechanism underlying breast carcinogenesis
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Transcriptome profiling associated with CARD11 overexpres-sion in Colorectal Cancer implicates a potential role for Tumour Immune Microenvironment and Cancer pathways modulation via NF-κB
<p>tables for CARD11</p>
Transcriptome profiling associated with CARD11 overexpres-sion in Colorectal Cancer implicates a potential role for Tumour Immune Microenvironment and Cancer pathways modulation via NF-κB
<p>Images for CARD11 study in IJMS</p>
Salt-inducible kinase 3 protects tumor cells from cytotoxic T-cell attack by promoting TNF-induced NF-κB activation
<p>WHAT IS ALREADY KNOWN ON THIS TOPIC</p> <ul> <li> <p>Tumor-intrinsic resistance to T cell (TC)-released cytokines, such as tumor necrosis factor (TNF)-α, has recently emerged as a major mechanism of tumor immune evasion. Yet, a deeper characterization of the genes that are responsible for this effect is needed.</p> </li> </ul> <p>WHAT THIS STUDY ADDS</p> <ul> <li> <p>Salt-inducible kinase 3 (SIK3) is a novel regulator of tumor-intrinsic resistance to cytotoxic TC attack.</p> </li> <li> <p>SIK3 confers tumor cell protection from TC-released TNF by sustaining the expression of pro-survival and anti-apoptotic genes under the control of nuclear factor kappa B (NF-κB).</p> </li> <li> <p>A TNF/SIK3/NF-κB-mediated gene signature correlated with significantly reduced patient survival in pancreatic cancer.</p> </li> </ul> <p>HOW THIS STUDY MIGHT AFFECT RESEARCH, PRACTICE AND/OR POLICY</p> <ul> <li> <p>Pharmacological inhibition of SIK3 might be an effective strategy to sensitize cancer cells to TC-based immunotherapies by rewiring tumor cell responses to TC-secreted TNF.</p> </li> </ul>
Silencing of TRAF5 enhances necroptosis in hepatocellular carcinoma by inhibiting LTBR-mediated NF-κB signaling
<p>Raw data of the article titled Silencing of TRAF5 enhances necroptosis in hepatocellular carcinoma by inhibiting LTBR-mediated NF-κB signaling</p>
Fig. 7 in Sesquiterpenes from Kadsura coccinea attenuate rheumatoid arthritis-related inflammation by inhibiting the NF-κB and JAK2/STAT3 signal pathways
Fig. 7. Experimental validation of the representative signaling pathways in vitro. Compound 19 inhibited the NF-kB (A) and JAK2/STAT3 (B) signaling pathways in RAW 264.7 cells induced by LPS. #p <0.05 compared with control group. *p <0.05, **p <0.01 compared with model group.
Fig. 6 in Sesquiterpenes from Kadsura coccinea attenuate rheumatoid arthritis-related inflammation by inhibiting the NF-κB and JAK2/STAT3 signal pathways
Fig. 6. (A) The gene ontology (GO) enrichment analysis for potential targets. (B) The KEGG pathway enrichment analysis of potential targets. (C) The drugcompound-target-pathway (D-C-T-P) network established by Cytoscape V 3.6.0. The red node represents K. coccinea, the yellow represents active compounds, the blue nodes represent targets, and the green nodes represent the pathways. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Fig. 5 in Sesquiterpenes from Kadsura coccinea attenuate rheumatoid arthritis-related inflammation by inhibiting the NF-κB and JAK2/STAT3 signal pathways
Fig. 5. The networks of sesquiterpenoid compounds of K. coccinea in treating rheumatoid arthritis. (A) The drug-compound-target (D-C-T) network of K. coccinea. The red node represents K. coccinea, the yellow represents active compounds, and the blue nodes represent targets. (B) The protein-protein interaction (PPI) network of protein targets obtained from the STRING database and visualized by Cytoscape V 3.6.0. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
TSG101 Associates with PARP1 and is Essential for PARylation and DNA Damage-induced NF-κB Activation
<p>This dataset contains the raw luciferase assay data generated in the genome-wide siRNA screen.</p>
Eupatorin modulates BCPAP in thyroid cancer cell proliferation via suppressing the NF-κB/P13K/AKT signaling pathways
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Fig. 3 in Sesquiterpenes from Kadsura coccinea attenuate rheumatoid arthritis-related inflammation by inhibiting the NF-κB and JAK2/STAT3 signal pathways
Fig. 3. Key ROESY correlations of compounds 1and 2.
Fig. 1 in Sesquiterpenes from Kadsura coccinea attenuate rheumatoid arthritis-related inflammation by inhibiting the NF-κB and JAK2/STAT3 signal pathways
Fig. 1. Structures of compounds 1–20 from K. coccinea.
Fig. 2. Key 1H–1H in Sesquiterpenes from Kadsura coccinea attenuate rheumatoid arthritis-related inflammation by inhibiting the NF-κB and JAK2/STAT3 signal pathways
Fig. 2. Key 1H–1H COSY and HMBC correlations of compounds 1and 2.
Fig. 1 in Norlignan glucosides from Hypoxis hemerocallidea and their potential in vitro anti-inflammatory activity via inhibition of iNOS and NF-ΚB
Fig. 1. Structures of compounds 1–7 and X-Z.
Fig. 2. Key HMBC correlations and COSY couplings for compounds 1–7, Y in Norlignan glucosides from Hypoxis hemerocallidea and their potential in vitro anti-inflammatory activity via inhibition of iNOS and NF-ΚB
Fig. 2. Key HMBC correlations and COSY couplings for compounds 1–7, Y, and Z.
Data from: NF-κB oscillations translate into functionally related patterns of gene expression
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RRAD, IL4I1, CDKN1A, and SERPINE1 genes are potentially co-regulated by NF-κB and p53 transcription factors in cells exposed to high doses of ionizing radiation [RNA-Seq]
GEO Series GSE110762. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Granulosa cell-derived serum TNF-α mediates inflammation and apoptosis in renal tubular cells through NF-κB signaling and indicates PCOS-related kidney injury.
GEO Series GSE229106. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
EZH1/SUZ12 complex positively regulates the transcription of NF-κB target genes via interaction with UXT
GEO Series GSE75217. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.