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56 results for “NFAT”
NFAT transcriptome in T-ALL
<p><span>T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy with few available targeted therapies. We previously reported that the phosphatase calcineurin (Cn) is required for LIC (leukemia Initiating Capacity) potential of T-ALL pointing to Cn as an interesting therapeutic target. Calcineurin inhibitors have however unwanted side effects. NFAT transcription factors play crucial roles downstream of calcineurin during thymocyte development, T cell differentiation, activation and energy. Here we elucidate NFAT functional relevance in T-ALL. Using murine T-ALL models in which <i>Nfat </i>genes can be inactivated either singly or in combination, we show that NFATs are required for T-ALL LIC potential and essential to survival, proliferation and migration of T-ALL cells. We also demonstrate that <i>Nfat </i>genes<i> </i>are functionally redundant in T-ALL and identified a node of genes commonly deregulated upon Cn or NFAT inactivation, which may serve as future candidate targets for T-ALL. </span></p>
NFAT-Dependent Cytokine Gene Expression for Immune Monitoring in Kidney Transplant Patients
ClinicalTrials.gov study NCT01771705. IPD Sharing: Not stated. Countries: 1. Publications: 7.
NFAT transcriptome in T-ALL
Open the record for dataset details and reuse information.
Tacrolimus Adjustment by NFAT-related Gene Expression in Lung Allograft Recipients.
ClinicalTrials.gov study NCT02278952. IPD Sharing: Not stated. Countries: 1. Publications: 0.
NFAT Mediates Pro-Tumorigenic Inflammation in Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma [mouse model]
GEO Series GSE292093. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
NFAT Mediates Pro-Tumorigenic Inflammation in Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma [mouse multiome]
GEO Series GSE292094. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Select EZH2 inhibitors enhance the viral mimicry effects of DNMT inhibition through a mechanism involving Calcium-Calcineurin-NFAT signaling [EPIC]
GEO Series GSE237553. Homo sapiens. 10 samples. Type: Methylation profiling by genome tiling array.
Lag3 and PD-1 pathways regulate NFAT-dependent TCR signalling programmes during early CD4+ T cell activation
GEO Series GSE260895. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Exploring Regulatory Mechanisms of Atrial Myocyte Hypertrophy of Mitral Regurgitation through Gene Expression Profiling Analysis: Role of NFAT in Cardiac Hypertrophy
GEO Series GSE63045. Homo sapiens. 10 samples. Type: Expression profiling by array.
R406-Inhibition of Syk-Cn-NFAT Signaling Axis Promotes Chemical Reprogramming via Metabolic Rewiring and H2S Production
GEO Series GSE154687. Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Select EZH2 inhibitors enhance the viral mimicry effects of DNMT inhibition through a mechanism involving Calcium-Calcineurin-NFAT signaling [siQ-ChIP]
GEO Series GSE236897. Homo sapiens. 15 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
CRELD2 is a novel modulator of calcium mobilisation and calcineurin-NFAT signalling during osteoclast differentiation
GEO Series GSE199189. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Select EZH2 inhibitors enhance the viral mimicry effects of DNMT inhibition through a mechanism involving Calcium-Calcineurin-NFAT signaling [EM-seq]
GEO Series GSE237662. Homo sapiens. 6 samples. Type: Methylation profiling by high throughput sequencing.
Calcineurin-NFAT signaling controls the neutrophils´ ability of chemoattraction upon fungal infection.
GEO Series GSE259282. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
NFAT Mediates Pro-Tumorigenic Inflammation in Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma [human multiome]
GEO Series GSE292095. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Targeting chronic NFAT activation with calcineurin inhibitors in diffuse large B-cell lymphoma
GEO Series GSE140882. Homo sapiens. 27 samples. Type: Expression profiling by array.
NFAT signalling in human mesenchymal stromal cells affects extracellular matrix metabolism and anti-fungal immune responses
GEO Series GSE157981. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Select EZH2 inhibitors enhance the viral mimicry effects of DNMT inhibition through a mechanism involving Calcium-Calcineurin-NFAT signaling [RNA-seq]
GEO Series GSE236896. Homo sapiens. 33 samples. Type: Expression profiling by high throughput sequencing.
NFAT Mediates Pro-Tumorigenic Inflammation in Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma [mouse VIVIT]
GEO Series GSE292096. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
NFAT-regulated Gene Expression After Tacrolimus
ClinicalTrials.gov study NCT03315858. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.