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183
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ShareScore release 0.9.0
Dataset results
183 results for “Neural tube”
Addressing the impact of surface ectoderm and somitic mesoderm development on neural tube morphogenesis
<p>This dataset was generated during the implementation of the MSCA individual fellowship project (<a>101038073</a>).</p>
Global analysis of cell behavior and protein localization dynamics reveals region-specific functions for Shroom3 and N-cadherin during neural tube closure
<p>Failures of neural tube closure are common and serious birth defects, yet we have a poor understanding of the interaction of genetics and cell biology during neural tube closure. Additionally, mutations that cause neural tube defects (NTDs) tend to affect anterior or posterior regions of the neural tube but rarely both, indicating a regional specificity to NTD genetics. To better understand the regional specificity of cell behaviors during neural tube closure, we analyzed the dynamic localization of actin and N-cadherin via high-resolution tissue-level time-lapse microscopy during Xenopus neural tube closure. To investigate the regionality of gene function, we generated mosaic mutations in shroom3, a key regulator or neural tube closure This approach elucidates new differences between cell behaviors during cranial/anterior and spinal/posterior neural tube closure, provides mechanistic insight into the function of shroom3 and demonstrates the ability of tissue-level imaging and analysis to generate cell-biological mechanistic insights into neural tube closure.</p>
Data from: Feedback between tissue packing and neurogenesis in the zebrafish neural tube
Balancing the rate of differentiation and proliferation in developing tissues is essential to produce organs of robust size and composition. Although many molecular regulators have been established, how these connect to physical and geometrical aspects of tissue architecture is poorly understood. Here, using high-resolution timelapse imaging, we find that changes to cell geometry associated with dense tissue packing play a significant role in regulating differentiation rate in the zebrafish neural tube. Specifically, progenitors that are displaced away from the apical surface due to crowding, tend to differentiate in a Notch-dependent manner. Using simulations we show that interplay between progenitor density, cell shape and changes in differentiation rate could naturally result in negative-feedback control on progenitor cell number. Given these results, we suggest a model whereby differentiation rate is regulated by density dependent effects on cell geometry to: (1) correct variability in cell number; and (2) balance the rates of proliferation and differentiation over development to 'fill' the available space.
Somitic mesoderm morphogenesis is necessary for neural tube closure during Xenopus development
<p>Data generated during the implementation of the MSCA infividual fellowship project 101038073.</p>
Powder Topical Rifampicin on Reducing Infections After Neural Tube Defect Surgery in Infants
ClinicalTrials.gov study NCT03198819. IPD Sharing: YES. Countries: 1. Publications: 3.
Short- Term Follow up Of Neonates Born With Neural Tube Defect
ClinicalTrials.gov study NCT04760509. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Prediction of Endotracheal Tube Depth by Using Deep Convolutional Neural Networks
ClinicalTrials.gov study NCT05085743. IPD Sharing: Not stated. Countries: 1. Publications: 8.
Data from: Feedback between tissue packing and neurogenesis in the zebrafish neural tube
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Global analysis of cell behavior and protein localization dynamics reveals region-specific functions for Shroom3 and N-cadherin during neural tube closure
Open the record for dataset details and reuse information.
Data from: Transcriptional response of Hoxb genes to retinoid signalling is regionally restricted along the neural tube rostrocaudal axis
During vertebrate neural development, positional information is largely specified by extracellular morphogens. Their distribution, however, is very dynamic due to the multiple roles played by the same signals in the developing and adult neural tissue. This suggests that neural progenitors are able to modify their competence to respond to morphogen signalling and autonomously maintain positional identities after their initial specification. In this work, we take advantage of in vitro culture systems of mouse neural stem/progenitor cells (NSPCs) to show that NSPCs isolated from rostral or caudal regions of the mouse neural tube are differentially responsive to retinoic acid (RA), a pivotal morphogen for the specification of posterior neural fates. Hoxb genes are among the best known RA direct targets in the neural tissue, yet we found that RA could promote their transcription only in caudal but not in rostral NSPCs. Correlating with these effects, key RA-responsive regulatory regions in the Hoxb cluster displayed opposite enrichment of activating or repressing histone marks in rostral and caudal NSPCs. Finally, RA was able to strengthen Hoxb chromatin activation in caudal NSPCs, but was ineffective on the repressed Hoxb chromatin of rostral NSPCs. These results suggest that the response of NSPCs to morphogen signalling across the rostrocaudal axis of the neural tube may be gated by the epigenetic configuration of target patterning genes, allowing long-term maintenance of intrinsic positional values in spite of continuously changing extrinsic signals.
Data from: Transcriptional response of Hoxb genes to retinoid signalling is regionally restricted along the neural tube rostrocaudal axis
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microRNA-seq from neural tube (ENCSR107JRF)
GEO Series GSE105278. Mus musculus. 2 samples. Type: Non-coding RNA profiling by high throughput sequencing.
ChIP-seq from neural tube (ENCSR240OUM)
GEO Series GSE82523. Mus musculus. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
ChIP-seq from neural tube (ENCSR704IWS)
GEO Series GSE82894. Mus musculus. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
ChIP-seq from neural tube (ENCSR448TTC)
GEO Series GSE82702. Mus musculus. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
DEVELOPMENTAL MicroRNA EXPRESSION PROFILING OF MURINE NEURAL TUBE
GEO Series GSE20879. Homo sapiens; Mus musculus; Rattus norvegicus. 9 samples. Type: Non-coding RNA profiling by array.
ChIP-seq from neural tube (ENCSR918ZSJ)
GEO Series GSE83019. Mus musculus. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
DNase-seq from neural tube (ENCSR312QVY)
GEO Series GSE83171. Mus musculus. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Modelling rostro-caudal neural tube regionalization from human embryonic stem cells with a microfluidic morphogenic gradient
GEO Series GSE135399. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
Aberrant expression of histone homocysteinylation: Implications for neural tube defects (ChIP-seq)
GEO Series GSE104093. Mus musculus. 3 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.