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2 results for “Neuroethology”
Mapping the neuroethological signatures of pain, analgesia and recovery in mice
<p><strong>Mapping the neuroethological signatures of pain, analgesia and recovery in mice.</strong><br> Repository containing datasets obtained for M. Bohic, L Pattison, et al. 2023. Neuron. </p> <p><strong>Abstract</strong><br> Ongoing pain is driven by direct activation of pain-sensing neurons and neuroimmune mediated sensitization. These heightened pain states alter physiology, reduce motor function, and affect motivation to engage in normal behaviors. The complexity of the pain state has evaded a comprehensive definition, especially in nonverbal animals. Here in mice, we capture the physiological state of sensitized neurons and use computational tools to automatically map behavioral signatures of evoked and spontaneous displays of pain at different time points for both an acute model of paw inflammatory pain and a chronic model of knee joint pain. First, retrograde labeling coupled with electrophysiology of neurons innervating injury sites revealed key time points corresponding to peripheral sensitivity in multiple pain models. Next, we used high-speed videography combined with supervised and unsupervised machine learning tools to uncover sensory-evoked defensive coping postures, unique to each pain condition. Using 3D pose analytics inspired by natural language processing, we identify movement sequences that correspond to robust representations of ongoing pain states. With this new analytical framework, we find that commonly used analgesics do not return an animal’s behavior to a pre-injury state. Instead, animals adopt a novel set of spontaneous behaviors that are maintained even after most evoked behavioral features of pain have resolved. Together, these findings reveal previously unidentified neuroethological signatures of pain and analgesia at timescales when inflammation induces heightened pain states and during recovery.</p>
A molecular neuroethological approach for identifying and characterizing a melody of behaviorally regulated genes
GEO Series GSE4629. Taeniopygia guttata. 14 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.