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ShareScore release 0.9.0
Dataset results
720 results for “Neuropathic pain”
Study of Mirogabalin for Central Neuropathic Pain
ClinicalTrials.gov study NCT03901352. IPD Sharing: YES. Countries: 3. Publications: 3.
DS-5565 Phase III Study for Diabetic Peripheral Neuropathic Pain
ClinicalTrials.gov study NCT02318706. IPD Sharing: YES. Countries: 1. Publications: 1.
Fibroblast-derived PI16 as a novel regulator of neuropathic pain
<p>Non-neuronal cells, including glia and leukocytes contribute to chronic pain. Here we identify fibroblasts secreting the protein PI16 as novel regulator of neuropathic pain. Mice deficient in PI16, a member of the CAP superfamily of proteases, are protected against neuropathic pain induced by spared nerve injury (SNI) or paclitaxel. SNI increases PI16 in fibroblasts and in vitro myofiborblast differentiation increases PI16 expression and secretion. In vitro, PI16 conditioned medium promotes migration of immune cells across the endothelial layer. Consistently, protection against neuropathic pain in PI16-/- mice was associated with reduced endothelial barrier permeability, lower leukocyte infiltration and reduced activation of the endothelial barrier regulator MLCK. Collectively our findings indicate that the fibroblast- derived protein PI16 promotes neuropathic pain by increasing vascular permeability and cellular infiltration. Due to its key role in pain and limited cellular distribution PI16 is an attractive novel target for pain management.</p>
Role of supraspinal sphingosine-1-phosphate receptor 1 in neuropathic pain
<p><span>An unbiased transcriptomic analysis of the RVM was used to identify genes affected by nerve injury and the impact of S1PR1 antagonism. </span></p>
Feasibility of using remotely delivered Spring Forest Qigong to reduce neuropathic pain in adults with spinal cord injury: A pilot study
<p class="mb15"><strong>Introduction:</strong> Approximately 69% of 299,000 Americans with spinal cord injury (SCI) suffer debilitating chronic neuropathic pain, which is intractable to treatment. The aim of this study is to determine feasibility, as the primary objective, and estimates of efficacy of a remotely delivered Qigong intervention in adults with SCI-related neuropathic pain, as the secondary objective.</p> <p class="mb15"><strong>Methods:</strong> We recruited adults with SCI-related neuropathic pain, with SCI ≥3 months, with complete or incomplete SCI, and highest neuropathic pain level of >3 on the Numeric Pain Rating Scale (NPRS), using nationwide volunteer sampling. Using a non-randomized controlled trial design, participants practiced Spring Forest Qigong's "Five Element Qigong Healing Movements" (online video) by combining movement to the best of their ability with kinesthetic imagery, at least 3x/week for 12 weeks. Adherence was automatically tracked through the Spring Forest Qigong website. Outcomes of neuropathic pain intensity (NPRS) were assessed weekly, and SCI-related symptoms were assessed at baseline, 6, and 12 weeks of Qigong practice and at 6-week and 1-year follow-ups.</p> <p class="mb15"><strong>Results:</strong> We recruited 23 adults with chronic SCI (7/2021–2/2023). In total, 18 participants started the study and completed all study components, including the 6-week follow-up. Twelve participants completed the 1-year follow-up assessment. Feasibility was demonstrated through participants' willingness to participate, adherence, and acceptability of the study. Mean age of the 18 participants was 60 ± 12 years, and they were 15 ± 11 years post-SCI with the highest baseline <em>neuropathic pain</em> of 7.94 ± 2.33, which was reduced to 4.17 ± 3.07 after 12 weeks of Qigong practice (Cohen's <em>d</em> = 1.75). This pain relief remained at 6-week and 1-year follow-ups. Participants reported reduced spasm frequency (change score 1.17 ± 1.20, <em>d</em> = 0.98) and severity (0.72 ± 1.02, <em>d</em> = 0.71), reduced interference of neuropathic pain on mood (3.44 ± 2.53, <em>d</em> = 1.36), sleep (3.39 ± 2.40, <em>d</em> = 1.41), daily activities (3.17 ± 2.77, <em>d</em> = 1.14), greater ability to perform functional activities (6.68 ± 3.07, <em>d</em> = 2.18), and improved mood (2.33 ± 3.31, <em>d</em> = 0.70) after Qigong.</p> <p class="mb15"><strong>Discussion:</strong> Remote Spring Forest Qigong's "Five Element Qigong Healing Movements" practice is feasible in adults with SCI-related neuropathic pain, with promising prolonged results of neuropathic pain relief and improvement in SCI-related symptoms after Qigong practice.</p> <p class="mb15"><strong>Clinical trial registration:</strong> <a href="https://www.clinicaltrials.gov/ct2/show/NCT04917107">https://www.clinicaltrials.gov/ct2/show/NCT04917107</a>, identifier NCT04917107</p>
Combined Peripheral (BreEStim) and Central Electrical Stimulation (tDCS) for Neuropathic Pain Management - Spinal Cord Injury
ClinicalTrials.gov study NCT03302793. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Neuropathic Pain in Knee Osteoarthritis: Pain Severity and Functional Status
ClinicalTrials.gov study NCT07367126. IPD Sharing: YES. Countries: 1. Publications: 6.
Maintenance of Effect of Duloxetine in Patients With Diabetic Peripheral Neuropathic Pain (DPNP)
ClinicalTrials.gov study NCT00322621. IPD Sharing: Not stated. Countries: 4. Publications: 2.
A Study of Sativex® for Relief of Peripheral Neuropathic Pain Associated With Allodynia.
ClinicalTrials.gov study NCT00711880. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effects of Vaporized Marijuana on Neuropathic Pain
ClinicalTrials.gov study NCT01037088. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Does the Application of Cold Decreases the Pain Associated in the Pose of a Patch of Capsaicine at High Concentration on the Carrier Patients of Localized Neuropathic Pains ? - DIDOCAP
ClinicalTrials.gov study NCT02869867. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Virtual Walking to Reduce Chronic Neuropathic Pain in Subjects With SCI
ClinicalTrials.gov study NCT07165353. IPD Sharing: NO. Countries: 1. Publications: 28.
Comparison of 10 kHz SCS Combined With CMM to CMM Alone in the Treatment of Neuropathic Limb Pain
ClinicalTrials.gov study NCT03228420. IPD Sharing: Not stated. Countries: 1. Publications: 9.
Chronic Pain Master Protocol (CPMP): A Study of LY3016859 in Participants With Diabetic Peripheral Neuropathic Pain
ClinicalTrials.gov study NCT04476108. IPD Sharing: YES. Countries: 2. Publications: 1.
Neurotropin to Treat Chronic Neuropathic Pain
ClinicalTrials.gov study NCT00006289. IPD Sharing: Not stated. Countries: 1. Publications: 3.
A Study of Sativex® for Pain Relief of Peripheral Neuropathic Pain, Associated With Allodynia
ClinicalTrials.gov study NCT00710554. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Tapentadol Prolonged Release (PR) Versus Oxycodone/Naloxone Prolonged Release in Severe Chronic Low Back Pain With a Neuropathic Component.
ClinicalTrials.gov study NCT01838616. IPD Sharing: Not stated. Countries: 4. Publications: 1.
Efficacy of Intrathecal Oxytocin in Patients With Neuropathic Pain
ClinicalTrials.gov study NCT02100956. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Tariquidar-ondansetron Combination in Neuropathic Pain
ClinicalTrials.gov study NCT04603066. IPD Sharing: Not stated. Countries: 1. Publications: 3.
A Clinical Study in Subjects With Neuropathic Pain From PHN Who Have Had an Inadequate Response to Gabapentin Treatment
ClinicalTrials.gov study NCT00617461. IPD Sharing: Not stated. Countries: 2. Publications: 1.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.