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91 results for “Nitazoxanide”
Macrophage targeting of nitazoxanide-loaded transethosomal gel in cutaneous leishmaniasis
<p>Topical delivery is preferable over systemic delivery for cutaneous leishmaniasis (CL), because of its easy administration, reduced systemic adverse effects, and low cost. Nitazoxanide (NTZ) has broad-spectrum activity against various parasites and has the potential to avoid drug resistance developed by enzymatic mutations. NTZ oral formulation is being associated with severe dyspepsia and stomach pain. Herein, NTZ-transethosomes (NTZ-TES) were prepared and loaded into chitosan gel (NTZ-TEG) for topical delivery. NTZ-TES were prepared by thin-film-hydration method and optimized statistically via Box-Behnken method. The optimized formulation indicated excellent particle size (176 nm), PDI (0.093), zeta potential (-26.4 mV) and entrapment efficiency (EE, 86%). The TEM analysis showed spherical sized particles and FTIR analysis indicated no interaction among the excipients. Similarly, NTZ-TEG showed optimal pH, desirable viscosity and good spreadability. NTZ-TES and NTZ-TEG showed prolonged release behavior and higher skin penetration and deposition in epidermal/dermal layer of skin in comparison with the NTZ-dispersion. Moreover, NTZ-TES showed higher percentage inhibition, lower IC50 against promastigotes and higher macrophage uptake. Additionally, skin irritation and histopathology studies indicated the safe and non-irritant behavior of the NTZ-TEG. The obtained findings suggested the enhanced skin permeation and improved anti-leishmanial effect of NTZ when administered as NTZ-TEG.</p>
The successful treatment of Enterocytozoon bieneusi Microsporidiosis with nitazoxanide in a patient with B-ALL: A case report
<div> <strong>Introduction</strong>: <em>Enterocytozoon</em> <em>bieneusi</em> (<em>E</em>. <em>bieneusi</em>) Microsporidia can cause opportunistic infections in immunocompromised patients and is also an emerging disease in these individuals. Its clinical manifestations are chronic diarrhea and severe wasting syndrome, these can be extremely debilitating and carry a significant risk of death for immunocompromised patients. Often, microsporidia cannot be confirmed immediately by routine examination and culture. Effective and available treatment options are limited for infections caused by <em>E</em>. <em>bieneusi</em> in humans. Such cases are very rare in the Chinese Mainland.</div> <div> </div> <div> <strong>Case Presentation</strong>: A 47-year-old male had recurrent, profuse watery diarrhea and abdominal discomfort for more than 7 months, with a fever for 5 days. Two years earlier, he received treatment with a modified BFM-90 protocol for acute B cell lymphoblastic leukemia and is currently in the final stages of maintenance therapy with oral methotrexate and mercaptopurine. The leukemia was assessed as still in remission two months ago. PET/CT showed massive peritoneal fluid accumulation and a high uptake area in the diffused peritoneum (SUVmax 12.57), suggesting tumor invasion or microbial infections. However, broad-spectrum antibacterial therapies were ineffective. Metagenomic sequencing of plasma and peritoneal fluid showed no suggestion of the existence of a tumor but instead showed a high sequence number of DNA and RNA of the Microsporidia. His albendazole treatment failed and subsequent treatment with nitazoxanide successfully resolved the infection.</div> <div> </div> <div> <strong>Conclusion</strong>: This case shows that we should consider the possibility of atypical pathogen infection in patients with hematologic malignancy who repeatedly develop unexplained diarrhea with wasting. mNGS can help rule out malignant neoplasms and diagnose infections. Our results suggest that nitazoxanide effectively treats <em>E</em>. <em>bieneusi</em> microsporidia infections. </div>
Nitazoxanide Plus Ribavirin and Peginterferon for Therapy of Treatment Naive HCV Genotype 1 and HIV Coinfected Subjects
ClinicalTrials.gov study NCT00991289. IPD Sharing: Not stated. Countries: 2. Publications: 2.
Effects of Early Use of Nitazoxanide in Patients With COVID-19
ClinicalTrials.gov study NCT04552483. IPD Sharing: YES. Countries: 1. Publications: 4.
Nitazoxanide Versus Placebo for the Treatment of Hospitalized Subjects With Severe Acute Respiratory Illness
ClinicalTrials.gov study NCT02057757. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
A Safety and Tolerability Study of Nitazoxanide in HIV-HCV Treatment Failures
ClinicalTrials.gov study NCT01185028. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Trial to Evaluate Efficacy and Safety of Nitazoxanide in the Treatment of Mild or Moderate COVID-19
ClinicalTrials.gov study NCT04486313. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Efficacy of Nitazoxanide in the Treatment of Chronic Hepatitis C Virus (HCV)
ClinicalTrials.gov study NCT01276756. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Nitazoxanide Therapy for Patients With COVID-19 Pneumonia
ClinicalTrials.gov study NCT04561219. IPD Sharing: YES. Countries: 1. Publications: 7.
Safety and Efficacy Study of Nitazoxanide in the Treatment of Acute Uncomplicated Influenza
ClinicalTrials.gov study NCT01227421. IPD Sharing: Not stated. Countries: 1. Publications: 1.
NNITS-Nitazoxanide for Norovirus in Transplant Patients Study
ClinicalTrials.gov study NCT03395405. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The successful treatment of Enterocytozoon bieneusi Microsporidiosis with nitazoxanide in a patient with B-ALL: A case report
Open the record for dataset details and reuse information.
Macrophage targeting of nitazoxanide-loaded transethosomal gel in cutaneous leishmaniasis
Open the record for dataset details and reuse information.
Hydroxychloroquine vs Nitazoxanide in Patients With COVID-19
ClinicalTrials.gov study NCT04341493. IPD Sharing: YES. Countries: 1. Publications: 4.
Interest of Nitazoxanide Treatment of Enterocytozoon Bieneusi Intestinal Microsporidiosis
ClinicalTrials.gov study NCT05417815. IPD Sharing: NO. Countries: 2. Publications: 1.
Nitazoxanide and Lansoprazole Based Regimens for H. Pylori Management
ClinicalTrials.gov study NCT05184491. IPD Sharing: NO. Countries: 1. Publications: 0.
Efficacy of Pegylated Interferon Plus Ribavirin Plus Nitazoxanide in HCV Genotype 4 and HIV Coinfection
ClinicalTrials.gov study NCT01529073. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Efficacy and Safety of Nitazoxanide for the Treatment of Hospitalized Patients With Moderate COVID-19
ClinicalTrials.gov study NCT04348409. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Nitazoxanide as Adjuvant Therapy in Type 2 Diabetes Mellitus
ClinicalTrials.gov study NCT06010992. IPD Sharing: NO. Countries: 1. Publications: 1.
Nitazoxanide for the Treatment of Prolonged Diarrhea in Children
ClinicalTrials.gov study NCT01326338. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
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International Brain Laboratory public data
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OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.