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9 results for “Non-hormonal contraceptive”
Assessing PATL2 as a Non-hormonal Contraceptive Target
<p>PATL2 is an RNA-binding, translation repressing protein involved in the female reproductive system. In this article, we discuss the need for non-hormonal contraceptives, the viability of PATL2 as a protein target, as well as work completed and in progress to characterize PATL2.</p>
Characterization and Assessment of KCNU1/SLO3 as a Potential Non-hormonal Contraceptive Target
<p>The Structural Genomics Consortium (SGC) has recently embarked on its first research project in reproductive biology as a part of the SGC’s new open science Women’s and Children’s Health Program (WCHP). This program, which was generously funded by the Bill & Melinda Gates Foundation will focus on drug discovery for childhood diseases and development as well as reproductive biology and disease. One of the first initiatives of WCHP is to identify and characterize protein targets for non-hormonal contraceptive agents.</p> <p>Although most contraceptive strategies have focused on the female reproductive system, there is great interest in developing contraceptives for the male reproductive system. Ion channels in sperm are of interest as viable targets for non-hormonal contraceptives for several reasons. First, they are promising drug targets due to their involvement in various pathophysiologies as well as their roles in sperm capacitation and the acrosomal reaction. Second, they contain druggable sites at cell surfaces, and third, proteins that respond to ion signaling are essential to sperm cells which must adapt to changing environments and respond to cues from the female reproductive tract. It is worth noting that approximately 15% of current drug targets are ion channels. One potential target is potassium/calcium-activated channel subfamily U member I (KCNU1), sometimes referred to as SLO3, a potassium channel that is expressed solely in mammalian sperm<span>. </span>In this work, we will describe our efforts to characterize KCNU1 as a potential protein target for non-hormonal contraceptives.</p>
A promising target for non-hormonal contraception – The a/b Hydrolase Domain 2
<p>Summary of results in 2022 for a/b Hydrolase Domain 2 (ABHD2) in the scope of the Structural Genomics Consortium's Women’s and Children’s Health Initiative funded by the Bill & Melinda Gates Foundation for characterizing potential targets for new non-hormonal contraceptives.</p>
LF111 or Drospirenone Chew vs Non-hormonal Contraceptive Methods on Bone Mineral Density in Adolescent and Adult Women
ClinicalTrials.gov study NCT05303636. IPD Sharing: NO. Countries: 1. Publications: 7.
Assessing Ovastacin an Fetuin B as a Non-Hormonal Contraceptive Targets
<p>Ovastacin/Fetuin B cloning results with small scale expression</p>
Effects of NLS-133, a Potential Non-Hormonal "On-Demand" Male Contraceptive
ClinicalTrials.gov study NCT07393334. IPD Sharing: NO. Countries: 1. Publications: 0.
Metabolic Profile of Users of Hormonal and Non-hormonal Contraceptives
ClinicalTrials.gov study NCT03383185. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Depo-Provera: Bone Mineral Density and Total Body Calcium in Adolescent DP150CI Users and Non-Hormonal Contraception
ClinicalTrials.gov study NCT00139685. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Illumina sequencing of vaginal epithelial cells from women using depot medroxyprogesterone acetate or non-hormonal contraception
GEO Series GSE68229. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
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