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ShareScore release 0.9.0
Dataset results
22 results for “Non-obstructive azoospermia”
All-atom Molecular Dynamics Simulations of Meiosis 1-associated protein (M1AP) to Investagate the Impact of Known Missense Mutations Associated with Male Infertility through Non-obstructive Azoospermia
<p>Protein structure of meiosis 1-associated protein (M1AP) was modelled by using GalaxyWeb (from Seok Lab). We used this model to investigate the impact of variants (i.e., S50P, R266Q, P389L, G317R, and L430P) in M1AP which were recently associated with non-obstructive azoospermia (NOA). NOA is a male infertility-related condition causing absence of sperm in the seminal fluid due to meiosis failure. We aimed to elucidate the pathogenicity mechanisms of these five missense NOA-related mutations on M1AP by performing molecular modeling and molecular dynamics (MD) simulations. This dataset includes the results of 1000 ns MD simulations (two repeats, each 500 ns) for each of the mutant and wild-type systems.</p> <p>Systems were prepared in Visual Molecular Dynamics (VMD 1.9.3) by placing them in a TIP3P water box with approximately 20 Å thickness from the protein surface and neutralizing the system charge with 0.15 M KCl. Of note, only protein parts were kept for the submission to reduce the size of files. Nanoscale Molecular Dynamics (NAMD 2.13-CUDA) was used to perform MD simulations with CHARMM36m force field. For pressure and temperature controls, Nosé-Hoover Langevin barostat and Langevin thermostat were used. ShakeH algorithm of NAMD was applied for water molecule constraints. 12 Å cut-off distance was used for van der Waals interactions. Switching function starts at 10 Å and reaches zero at 14 Å. Integration time-step was 2 fs. To compute the long-range Coulomb interactions, the particle-mash Ewald method was used. NPT ensemble was applied for whole simulations. Two step minimization & equilibration procedure was performed: (1) 5,000-step minimization and 1 ns equilibrium with constraints on the protein; (2) 5,000-step minimization and 1 ns equilibrium without the constraints on the protein. All related configuration files for wild-type system were also included to the dataset. Production simulations were run twice along 500 ns by using different random seeds to assign the velocities from Boltzmann distribution (total simulation time for each system was 1000 ns, which are given as 500 ns repeat 1, and 500 ns repeat 2). The production simulations were supplied in the dataset. "out" and "log" files were used for energy analysis.</p> <p>For all analysis scripts, see https://github.com/ugerlevik/M1AP_analysis.</p>
NT-NOA - Novel Treatment of Some Men With Non-Obstructive Azoospermia
ClinicalTrials.gov study NCT06706414. IPD Sharing: NO. Countries: 1. Publications: 22.
Preimplantation Genetic Testing for Aneuploidy (PGT-A) in Couples With Non-obstructive Azoospermia (NOA)
ClinicalTrials.gov study NCT06566599. IPD Sharing: NO. Countries: 1. Publications: 8.
GnRHa Combined With hCG and hMG for Treatment of Patients With Non-obstructive Azoospermia
ClinicalTrials.gov study NCT02544191. IPD Sharing: Not stated. Countries: 1. Publications: 1.
RNA-seq based transcriptome profiles of the human testis tissues across multiple conditions, with an intention to mainly study non-obstructive azoospermia
GEO Series GSE216907. Homo sapiens. 14 samples. Type: Expression profiling by high throughput sequencing.
Biomarkers in semen/urine from non-obstructive azoospermia patients to predict the presence of testicular spermatozoa and spermatogonia
GEO Series GSE224511. Homo sapiens. 64 samples. Type: Non-coding RNA profiling by high throughput sequencing.
In situ transcriptomic analysis of spermatocytes in non-obstructive azoospermia reveals senescence-like states in arrested spermatocytes
GEO Series GSE238078. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Inflammation-induced lncRNA SNHG1 Orchestrates Spermatogonium Development in Non-obstructive Azoospermia via IL-17A Signaling Pathway
GEO Series GSE313132. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Microdissection Testicular Sperm Extraction (MicroTESE) and IVF-ICSI Outcome in Non-Obstructive Azoospermia (NOA)
ClinicalTrials.gov study NCT00484081. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Estradiol and Testosterone Levels in Seminal Plasma of Men With Non-obstructive Azoospermia
ClinicalTrials.gov study NCT02255396. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Spermatogonial Stem Cells in Azoospermic Patients: a Comparison Between Obstructive and Non-obstructive Azoospermia
ClinicalTrials.gov study NCT01178463. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Interest of Clomiphene Citrate in Patients With Non-obstructive Azoospermia on the Quantity of Sperm Cells
ClinicalTrials.gov study NCT03615547. IPD Sharing: NO. Countries: 1. Publications: 0.
Use of Semen TEX101 to Improve Sperm Retrieval Rates for Men With Non-obstructive Azoospermia
ClinicalTrials.gov study NCT02851966. IPD Sharing: UNDECIDED. Countries: 2. Publications: 0.
Intra-Testicular Transplantation of Autologous Stem Cells for Treatment of Non-Obstructive Azoospermia Male Infertility.
ClinicalTrials.gov study NCT02641769. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Identifying Genome Variants in Non-Obstructive Azoospermia (NOA) or Primary Ovarian Insufficiency (POI)
ClinicalTrials.gov study NCT07357701. IPD Sharing: NO. Countries: 1. Publications: 0.
CAIS molecular pathways unveil Testosterone/Estradiol ratio to germ cell tumor risk in non-obstructive azoospermia
GEO Series GSE298368. Homo sapiens. 1 samples. Type: Expression profiling by high throughput sequencing.
Whole Transcriptome analysis to identify non-coding RNA regulators and hub genes in Sperm of non-obstructive azoospermia by microarray
GEO Series GSE268452. Homo sapiens. 6 samples. Type: Expression profiling by array.
Potential biomarkers of non-obstructive azoospermia identified in microarray gene expression analysis
GEO Series GSE45885. Homo sapiens. 31 samples. Type: Expression profiling by array.
Profiling of Circulating extracellular vesicles microRNAs Reveals Diagnostic Potential and Pathways in Non-Obstructive and Obstructive Azoospermia
GEO Series GSE270320. Homo sapiens. 9 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Altered mRNA profile in testis of patients with“secondary idiopathic non-obstructive azoospermia”
GEO Series GSE190752. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
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