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Dataset results
27 results for “Normothermic machine perfusion”
Activation of autophagy during normothermic machine perfusion of discarded livers is associated with improved hepatocellular function
We demonstrate that ischemia-reperfusion injury occurs in all livers during NMP, though there are notable differences in gene expression between functional and nonfunctional livers. We further demonstrate that activation of the liver's repair and homeostasis mechanisms through autophagy plays a vital role in the graft's response to injury and may impact liver function. These findings indicate that liver autophagy might be a key therapeutic target for rehabilitating the function of severely injured or untransplantable livers.
Raw Data for the article: The use of normothermic machine perfusion to rescue liver allografts from expanded criteria donors
<p>The use of expanded criteria donors is one of the strategies used to overcome the gap between the demand for organs and the number of donors. Physicians debate the extent to which marginal grafts can be used. In recent years, normothermic machine perfusion (NMP) has been used to test liver viability before transplantation. Grafts underwent NMP whenever histological steatosis was > 40% or there were at least three Eurotransplant criteria for expanded criteria donor (ECD). We used NMP to test 19 grafts, 3 from donation after type 3 controlled cardiac death (DCD), and 16 from donation after brain death (DBD). Only two grafts from DBD were not transplanted, because perfusion proved they were not suitable (total of 17 transplanted grafts of 19 tested grafts). Kaplan-Meier survival estimates at 30, 90, 180, and 1 year after transplant were all 94% (95% CI 84-100%); estimated 3-years survival was 82% (95% CI 62-100%). Overall survival rates did not differ from those of patients transplanted with non-perfused grafts from an ECD. In our experience, the use of very marginal grafts preventively tested by NMP does not negatively influence the patient's outcome, and increases the number of transplants in low donation areas.</p>
Activation of autophagy during normothermic machine perfusion of discarded livers is associated with improved hepatocellular function
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Gene expression profiling of normothermic machine perfusion of human livers
<p>Normothermic machine perfusion (NMP) has been successfully implemented in clinical routine of liver transplantation over the past years. However, little is known about the mechanisms how NMP impacts on the transcriptome of a human donor liver. We herein examined gene expression profiles in transplanted and non-transplanted livers over NMP time. 50 livers subjected to NMP were included in this study. 30 were transplanted after a maximum of 20 hours (h) perfusion, while 15 were discarded due to poor performance. Biopsies were collected before NP (PRE), 1h, 6h, 12h, 20h of NMP and after reperfusion. Next-generation sequencing was applied in liver biopsies to assess differential gene expression over perfusion time. Perfusate samples were collected regularly to monitor liver function. Significantly differentially expressed genes between each timepoint and PRE (LIVER_NMP_TIMEPOINT_PRE_DEG.xlsx) as well as between non-transplanted livers (NTP) and transplanted livers (TP) (LIVER_NMP_NTP_TP_DEG.xlsx) were determined using the R package DESeq2 and included in this dataset.</p>
Data file: Equal performance of HTK-based and UW-based perfusion solutions in sub-normothermic liver machine perfusion
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Glycocalyx During Normothermic Machine Perfusion
ClinicalTrials.gov study NCT04764266. IPD Sharing: NO. Countries: 1. Publications: 0.
Normothermic Machine Perfusion (NMP) Versus Hypothermic Machine Perfusion (HMP) in Human Kidney Transplantation
ClinicalTrials.gov study NCT05743751. IPD Sharing: YES. Countries: 1. Publications: 4.
Normothermic Machine Perfusion (NMP) Versus Static Cold Storage (SCS) in Human Kidney Transplantation
ClinicalTrials.gov study NCT05031052. IPD Sharing: NO. Countries: 1. Publications: 1.
Efficacy Evaluation of Normothermic Perfusion Machine Preservation in Liver Transplant Using Very Old Donors
ClinicalTrials.gov study NCT02940600. IPD Sharing: NO. Countries: 1. Publications: 4.
Normothermic Machine Perfusion: an Additional Value for Kidney Transplant Outcomes?
ClinicalTrials.gov study NCT04882254. IPD Sharing: NO. Countries: 1. Publications: 3.
Assessing Declined Liver Grafts With Normothermic Machine Perfusion to Reduce Transplant Waiting Time
ClinicalTrials.gov study NCT06874296. IPD Sharing: NO. Countries: 1. Publications: 0.
Viability of discarded human livers during normothermic machine perfusion is associated with activation of repair mechanisms
GEO Series GSE165568. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic profiling during normothermic machine perfusion of human kidneys reveals a pro-inflammatory cellular landscape and gene expression signature associated with prolonged delayed graft func
GEO Series GSE293480. Homo sapiens. 7 samples. Type: Expression profiling by high throughput sequencing.
Cellular responses during kidney normothermic machine perfusion reflect graft outcomes
GEO Series GSE307631. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profiling of human livers during normothermic machine perfusion
GEO Series GSE263614. Homo sapiens. 206 samples. Type: Expression profiling by high throughput sequencing.
Normothermic machine perfusion (NMP) inhibits proinflammatory responses in the liver and promotes regeneration
GEO Series GSE112713. Homo sapiens. 48 samples. Type: Expression profiling by array.
Pan-caspase inhibition during normothermic machine perfusion of discarded livers mitigates ischemia-reperfusion injury
GEO Series GSE202565. Homo sapiens. 32 samples. Type: Expression profiling by high throughput sequencing.
Hypothermic Oxygenated (HOPE) Versus Normothermic Machine Perfusion (NMP) in Human Liver Transplantation
ClinicalTrials.gov study NCT04644744. IPD Sharing: NO. Countries: 1. Publications: 0.
Safety and Feasibility of Normothermic Machine Perfusion to Preserve and Evaluate Orphan Livers
ClinicalTrials.gov study NCT03456284. IPD Sharing: NO. Countries: 1. Publications: 0.
Post Static Cold Storage Normothermic Machine Liver Perfusion
ClinicalTrials.gov study NCT03176433. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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International Brain Laboratory public data
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OpenNeuro
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