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5 results for “ObgE”
YbiB: a Novel Interactor of the GTPase ObgE
<p>This dataset contains the raw data that lie at the basis of the results discussed in the paper entitled "YbiB: a Novel Interactor of the GTPase ObgE". <br> The accompanying README.txt file describes the specific data that can be found in the different raw data files.</p>
The role of the essential GTPase ObgE in regulating lipopolysaccharide synthesis in Escherichia coli
<p>Source data accompanying scientific publication.</p> <p>Abstract: <span>During growth, cells need to synthesize and expand their envelope, a process that requires careful regulation. Here, we show that the GTPase ObgE of <em>E. coli</em> contributes to the regulation of lipopolysaccharide (LPS) synthesis, an essential component of the Gram-negative outer membrane. Using a dominant-negative mutant (named ‘ObgE*’), we show a direct interaction between ObgE and LpxA, which catalyzes the first step in LPS synthesis. This interaction is enhanced by the mutation in ObgE* which, when bound to GTP, leads to inhibition of LpxA, decreased LPS synthesis, and cell death. Although wild-type ObgE does not exert the same strong effects as ObgE* on LpxA or LPS synthesis, our data indicate that ObgE participates in the regulation of cell envelope synthesis in <em>E. coli</em>. Because ObgE also influences other cellular functions (i.e., ribosome assembly, DNA replication, etc.), it seems increasingly plausible that this GTPase coordinates several processes to finetune cell growth.</span></p>
Ocular Bandage Gel (OBG) Pivotal Trial in Patients Undergoing Photorefractive Keratectomy ("PRK")
ClinicalTrials.gov study NCT03938883. IPD Sharing: NO. Countries: 1. Publications: 1.
Safety and Effectiveness of OBG vs.a Bandage Contact Lens for Large Corneal Epithelial Defects in Patients Post-PRK.
ClinicalTrials.gov study NCT03163641. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Expression data from Escherichia coli strains with increased or decreased levels of Obg (ObgE, CgtA, YhbZ)
GEO Series GSE62918. Escherichia coli. 12 samples. Type: Expression profiling by array.
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Allen Brain Atlas
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.