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312 results for “Optic nerve”
Involvement of the optic nerve in mutated CSF1R-induced hereditary diffuse leukoencephalopathy with axonal spheroids
<p><strong>Figure 1:</strong> Family pedigree. The arrow indicates the proband (present patient). Her mother developed a motor disorder at 40 years of age and died at 60 years of age. Her grandparents, father, brothers, sisters, and daughters were not affected.</p> <p><strong>Figure 2: Brain MRI, DWI, DTI, and MRS images. T2/Flair showed multifocal periventricular white matter lesions (A, B, and C), without enhancement (D). DWI shows high-signal intensities in periventricular white matters and corpus callosum (E, F). DTI shows decreased numbers of corpus callosum fibers, while subcortical arcuate fibers are spared (G). MRS shows increased Cho levels, while NAA levels are decreased in the white matter lesions (H, I).</strong></p> <p><strong>Figure 3: </strong>Optic nerves on MRI, showing that bilateral optic nerves are injured (red arrows). </p> <p><strong>Figure 4: </strong>OCT shows that the right peripapillary retinal nerve fiber layer (pRNFL) is atrophic in the temporal quadrant, and the left pRNFL is thinning in the temporal superior quadrants. Green represents pRNFL thickness, which is within normal limits; yellow represents pRNFL thickness, which is below borderline; red represents pRNFL thickness, which is below normal limits.</p> <p><strong>Figure 5:</strong> VEP shows reduced bilateral P100 amplitudes, although P100 latencies are normal in both eyes.</p> <p><strong>Figure 6:</strong> Visual fields in the right eye are partially missing in the upper right, lower right, and lower left quadrants, especially in the lower right quadrant. Visual fields in the left eye are partially missing in the four quadrants, especially in the upper left and lower right quadrants.</p> <p><strong>Figure 7:</strong> Gene analysis of <em>CSF1R</em>. The sequencing result from exon 18 of <em>CSF1R</em> (NM_005211.3) indicates a heterozygous c.2345 G>A (p.782Arg>His) substitution in the patient.</p>
Tensile properties of glaucomatous human sclera, optic nerve, and optic nerve sheath
<p><strong><span>Purpose</span></strong><span>. <span>We characterized the tensile behavior of sclera, optic nerve (ON), and ON sheath in eyes from donors with glaucoma, for comparison with published data without glaucoma.</span></span></p> <p><strong><span>Methods</span></strong><span>. <span>Twelve freshly harvested eyes were obtained from donors with history of glaucoma, of average age 86±7 (standard deviation) years. Rectangular samples were taken from anterior, equatorial, posterior, and peripapillary sclera, and ON sheath, while ON was in native form and measured using calipers. Under physiological temperature and humidity, tissues were preconditioned at 5% strain before loading at 0.1 mm/s. Force-displacement data were converted into engineering stress-strain curves fit by </span></span><span>reduced polynomial hyperelastic models</span><span>, and analyzed by tangent moduli at 3% and 7% strain. Data were compared with an age-matched sample of 7 published control eyes.</span></p> <p><strong><span>Results</span></strong><span>. <span>Optic atrophy was supported by significant reduction in ON cross-section to 73% of normal in glaucomatous eyes. Glaucomatous was significantly stiffer than control <span> </span>in equatorial and peripapillary regions (P<0.001). However, glaucomatous ON and sheath were significantly less stiff than control, particularly at low strain (P<0.001). Hyperelastic models were well fit to stress-strain data (R<sup>2</sup>>0.997). Tangent moduli had variability similar to control in most regions, but was abnormally large in peripapillary sclera. Tensile properties were varied independently among various regions of the same eyes. </span></span></p> <p><strong><span>Conclusion</span></strong><span>. <span>Glaucomatous sclera is abnormally stiff, but the ON and sheath are abnormally compliant. These abnormalities correspond to properties predicted by finite element analysis to transfer potentially pathologic stress to the vulnerable disc and lamina cribrosa region during adduction eye movement.</span></span></p>
Effect of Cervical Collar on the Optic Nerve Sheath Diameter in Minor Head Trauma
ClinicalTrials.gov study NCT03742427. IPD Sharing: NO. Countries: 1. Publications: 2.
Clinical Investigation on the Blood Oxygenation at the Optic Nerve Head in Fabry Patients
ClinicalTrials.gov study NCT02023086. IPD Sharing: UNDECIDED. Countries: 1. Publications: 4.
Glaucoma-associated optineurin mutations increase transcellular degradation of mitochondria in a vertebrate optic nerve
Open the record for dataset details and reuse information.
Involvement of the optic nerve in mutated CSF1R-induced hereditary diffuse leukoencephalopathy with axonal spheroids
<p>Figure legends</p> <p>Figure 1: Family pedigree. The arrow indicates the proband (present patient). Her mother developed a motor disorder at 40 years of age and died at 60 years of age. Her grandparents, father, brothers, sisters, and daughters were not affected.</p> <p> </p> <p>Figure 2: Brain MRI, DWI, DTI, and MRS images. T2/Flair showed multifocal periventricular white matter lesions (A, B, and C), without enhancement (D). DWI shows high-signal intensities in periventricular white matters and corpus callosum (E, F). DTI shows decreased numbers of corpus callosum fibers, while subcortical arcuate fibers are spared (G). MRS shows increased Cho levels, while NAA levels are decreased in the white matter lesions (H, I).</p> <p> </p> <p>Figure 3: Optic nerves on MRI, showing that bilateral optic nerves are injured (red arrows).</p> <p> </p> <p>Figure 4: OCT shows that the right peripapillary retinal nerve fiber layer (pRNFL) is atrophic in the temporal quadrant, and the left pRNFL is thinning in the temporal superior quadrants. Green represents pRNFL thickness, which is within normal limits; yellow represents pRNFL thickness, which is below borderline; red represents pRNFL thickness, which is below normal limits.</p> <p> </p> <p>Figure 5: VEP shows reduced bilateral P100 amplitudes, although P100 latencies are normal in both eyes.</p> <p> </p> <p>Figure 6: Visual fields in the right eye are partially missing in the upper right, lower right, and lower left quadrants, especially in the lower right quadrant. Visual fields in the left eye are partially missing in the four quadrants, especially in the upper left and lower right quadrants.</p> <p> </p> <p>Figure 7: Gene analysis of CSF1R. The sequencing result from exon 18 of CSF1R (NM_005211.3) indicates a heterozygous c.2345 G>A (p.782Arg>His) substitution in the patient.</p>
Subsurface Multi-Physical Monitoring of a Reservoir Landslide with the Fiber-Optic Nerve System
<p>All data used in the study to support this research is available on repository via 10.5281/zenodo.6541529</p>
Dataset for publication 'Automated g-ratio calculation of sciatic nerve bundles in mice – a new approach for optical microscopy '
<p>Dataset corresponding to the publication <strong>Automated g-ratio calculation of sciatic nerve bundles in mice – a new approach for optical microscopy</strong> intended for publication at Nature Scientific Reports. This repository contains the training, validation and test data.</p>
Effect of Anesthesia on Optic Nerve Sheath Diameter in Patients Undergoing Robot-assisted Laparoscopic Prostatectomy
ClinicalTrials.gov study NCT03271502. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Optical Nerve Sheath Changes During Head Down Laparoscopy
ClinicalTrials.gov study NCT03957837. IPD Sharing: Not stated. Countries: 1. Publications: 5.
ALPI vs Medical Therapy Effects on Optic Nerve Structure & Function
ClinicalTrials.gov study NCT00485238. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Neuroprognostication Using Optic Nerve Sheath Diameter
ClinicalTrials.gov study NCT03195881. IPD Sharing: NO. Countries: 1. Publications: 5.
Spectral Domain OCT Imaging in Patients With Optic Nerve Head Drusen (Tuebingen SD-OCT IN OPTIC NERVE HEAD DRUSEN STUDY)
ClinicalTrials.gov study NCT02793206. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Role of Nitric Oxide in Optic Nerve Head Blood Flow Regulation During Isometric Exercise in Healthy Humans
ClinicalTrials.gov study NCT00806741. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study on Optic Nerve Sheath Diameter Measurements in Prolonged Pediatric Seizures
ClinicalTrials.gov study NCT06451289. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
High-Resolution Optical Coherence Tomography for Detection of Retinal Nerve Fiber Layer Loss in Band Atrophy of the Optic Nerve
ClinicalTrials.gov study NCT00607100. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Neural Conduction Along the Visual Pathways After Oral Treatment With Citicoline in Patients With Optic Nerve Diseases
ClinicalTrials.gov study NCT00404729. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Intracranial Pressure and Optic Nerve Sheath Diameter With CLOSED Bundle
ClinicalTrials.gov study NCT06057155. IPD Sharing: YES. Countries: 1. Publications: 14.
Sonography of the Optic Nerve Sheath Diameter for Detection of Elevated Intracranial Pressure (ICP)
ClinicalTrials.gov study NCT03529370. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Assessment of Optic Nerve Sheath Diameter in Preeclamptic Pregnant Women Using Ultrasonography and Anesthetic Management
ClinicalTrials.gov study NCT06522295. IPD Sharing: UNDECIDED. Countries: 1. Publications: 4.
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.