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208 results for “Orthopedic surgery”
Safety and Pharmacokinetics Study of DU-176b Administered to Patients With Severe Renal Impairment Undergoing Orthopedic Surgery of The Lower Limbs
ClinicalTrials.gov study NCT01857583. IPD Sharing: YES. Countries: 1. Publications: 1.
How do patients sleep after orthopedic surgery? Changes in objective sleep parameters and pain in hospitalized patients undergoing hip and knee arthroplasty
<p><strong>Aim.</strong> Sleep impairment after hip and knee arthroplasty is multifactorial and still poorly understood and post-operative pain is a potential cause of sleep deprivation or disturbances. The aim of this study was to assess actigraphy-based sleep characteristics and pain scores in patients undergoing knee or hip joint replacement and hospitalized for ten days after surgery. <strong>Methods.</strong> In this observational cohort study, n=20 subjects (11 males and 9 females; age: 64.0±10.39 years old) completed a daily sleep diary and wore the Actiwatch 2 actigraph (Philips Respironics, Portland, OR) to record sleep parameters for 11 consecutive days, starting the day before surgery and ending the 10<sup>th</sup> day after surgery. Subjective scores of pain, by a visual analog scale (VAS), were constantly monitored for the entire experimental protocol. The following evaluation time-points have been considered for the analysis: pre-surgery (PRE), the first (POST1), the fourth (POST4) and the tenth day (POST10) after surgery. A repeated-measures one-way analysis of variance followed by the Tukey-Kramer post hoc tests, or the equivalent nonparametric Friedman test followed by the Dunn’s multiple comparisons, was applied to test differences in sleep and pain among time-points. Test for correlation between mean VAS score and the sleep parameters at each post-operative time point were performed using Pearson’s method. <strong>Results.</strong> Sleep quantity and timing parameters did not differ from PRE to POST10, during the hospitalization. On the contrary, Sleep Efficiency (p=0.006; η<sup>2</sup><sub>p</sub>=0.45, large), Sleep Latency (p=0.039; η<sup>2</sup><sub>p</sub>=0.37, large), Wake After Sleep Onset (p=0.042; η<sup>2</sup><sub>p</sub>=0.34, large), Immobility Time (p=0.005; η<sup>2</sup><sub>p</sub>=0.47, large) and Fragmentation Index (p=0.016; η<sup>2</sup><sub>p</sub>=0.36, large) displayed significant differences. In detail, Sleep Efficiency and Immobility Time significantly decreased at POST1 compared to PRE by 10.8% (p=0.003; ES: 0.9, moderate) and 9.4% (p=0.005; ES: 0.86, moderate) respectively. Overall, all sleep quality parameters showed a trend of constant improvement from POST1 to POST10. VAS scores were higher in the 1<sup>st</sup> day post-surgery (4.58 ± 2.46; p=0.0011 and ES: 1.40, large) compared to POST10 (1.68 ± 1.58) and in POST4 (3.85 ± 2.31) compared to POST10 (-2.18; p=0.0087 and ES: 1.09, moderate). During time, mean VAS showed significant negative correlations with mean Sleep Efficiency (r = -0.71; p=0.021) and mean Immobility Time (r = - 0.83; p=0.003) and a significant positive correlation with Fragmentation Index (r = 0.70; p=0.023), highlighting that high scores of pain were associated with lower overall sleep quality. <strong>Conclusion.</strong> Sleep quantity and timing parameters were stable during the entire hospitalization whereas sleep quality parameters significantly worsened the 1<sup>st</sup> night after surgery compared to the pre-surgery night and, overall, these parameters showed a trend of constant improvement until discharge. Pain scores were at the highest level the 1<sup>st</sup> day after surgery and at the lowest level before discharge with a negative correlation between pain and sleep quality parameters during time. The present study confirms the important impact of surgery on sleep parameters, especially on the first few post-operative days.</p>
Methadone Versus Morphine for Orthopedic Surgery Patients
ClinicalTrials.gov study NCT00892606. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Does Orthopedic Surgery Improve Gait Efficiency in Children With Cerebral Palsy? A Retrospective Study
ClinicalTrials.gov study NCT06624280. IPD Sharing: NO. Countries: 1. Publications: 19.
Pilot Study of Atorvastatin for Orthopedic Surgery Patients
ClinicalTrials.gov study NCT02197065. IPD Sharing: NO. Countries: 1. Publications: 1.
Perioperative Mental Health in Orthopedic Surgery
ClinicalTrials.gov study NCT05697835. IPD Sharing: NO. Countries: 1. Publications: 1.
Efficacy and Safety of IV Diclofenac (DIV075V)for Pain After Elective Orthopedic Surgery
ClinicalTrials.gov study NCT00507026. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Supporting the Health of Adults Undergoing Orthopedic Surgery During the Recovery Period
ClinicalTrials.gov study NCT00586196. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Opioid Consumption After Hospital Discharge in Orthopedic Surgery
ClinicalTrials.gov study NCT03185117. IPD Sharing: NO. Countries: 1. Publications: 2.
Regulation of Coagulation in Orthopedic Surgery to Prevent Deep Vein Thromboembolism (DVT) and Pulmonary Embolism (PE). A Study of BAY59-7939 in the Prevention of Venous Thrombo Embolism (VTE) in Subj
ClinicalTrials.gov study NCT00362232. IPD Sharing: Not stated. Countries: 13. Publications: 1.
Hypnosis for Symptom Management in Elective Orthopedic Surgery
ClinicalTrials.gov study NCT03308071. IPD Sharing: NO. Countries: 1. Publications: 1.
Psychological Factors and Pain in Orthopedic Surgery Patients
ClinicalTrials.gov study NCT06707363. IPD Sharing: YES. Countries: 1. Publications: 4.
Stellate Ganglion Block for Preserving Arteriovenous Fistula in Hemodialysis Patients Undergoing Major Lower Limb Orthopedic Surgery
ClinicalTrials.gov study NCT06300658. IPD Sharing: YES. Countries: 1. Publications: 1.
Brachial Plexus Block vs. General Anesthesia for Anesthesia Anxiety Before Orthopedic Upper Extremity Surgery
ClinicalTrials.gov study NCT05476198. IPD Sharing: YES. Countries: 1. Publications: 4.
Multimodal Pain Management After Wide Awake Local Anesthesia No Tourniquet Orthopedic Hand Surgery: A Randomized Control Trial
ClinicalTrials.gov study NCT06917118. IPD Sharing: NO. Countries: 1. Publications: 20.
Phase 3/4 Study of a Recombinant Protein-Free Factor VIII (rAHF-PFM): Comparison of Continuous Infusion Versus Intermittent Bolus Infusion in Hemophilia A Subjects Undergoing Major Orthopedic Surgery
ClinicalTrials.gov study NCT00357656. IPD Sharing: YES. Countries: 14. Publications: 0.
Supraclavicular Bupivacaine Vs. Supraclavicular Liposomal Bupivacaine for Orthopedic Wrist Surgery
ClinicalTrials.gov study NCT06179004. IPD Sharing: NO. Countries: 1. Publications: 8.
Cold Spray for Pain and Ecchymosis After Anticoagulant Prophylaxis in Orthopedic Surgery
ClinicalTrials.gov study NCT07195955. IPD Sharing: NO. Countries: 1. Publications: 9.
Dexmedetomidine Supplemented Intravenous Analgesia in Elderly After Orthopedic Surgery
ClinicalTrials.gov study NCT03629262. IPD Sharing: NO. Countries: 1. Publications: 24.
Broad-spectrum Antibiotic Prophylaxis in Tumor and Infected Orthopedic Surgery
ClinicalTrials.gov study NCT05502380. IPD Sharing: YES. Countries: 1. Publications: 5.
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