Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
98
datasets available to search
ShareScore release 0.9.0
Dataset results
98 results for “Osteoblast differentiation”
GAS5 protects against osteoporosis by targeting UPF1/SMAD7 axis in osteoblast differentiation
<p>Osteoporosis is a common systemic skeletal disorder resulting in bone fragility and increased fracture risk. It is still necessary to explore its detailed mechanisms and identify novel targets for the treatment of osteoporosis. Previously, we found that an lncRNA named GAS5 in humans could negatively regulate lipoblast/adipocyte differentiation. However, it is still unclear whether GAS5 affects osteoblast differentiation and whether GAS5 is associated with osteoporosis. Our current research found that GAS5 was decreased in the bones and BMSCs, a major origin of osteoblast, in osteoporosis patients. Mechanistically, GAS5 promotes osteoblast differentiation by interacting with UPF1 to degrade Smad7 mRNA. Moreover, a decreased bone mass and impaired bone repair ability were observed in <em>Gas5</em> heterozygous mice, manifesting in osteoporosis. The systemic supplement of <em>Gas5</em>-overexpressing adenoviruses significantly ameliorated bone loss in an osteoporosis mouse model. In conclusion, GAS5 promotes osteoblast differentiation by targeting the UPF1/Smad7 axis and protects against osteoporosis.</p>
GAS5 protects against osteoporosis by targeting UPF1/SMAD7 axis in osteoblast differentiation
Open the record for dataset details and reuse information.
Data from: Micro/nano-hierarchical structured TiO2 coating on titanium by micro-arc oxidation enhances osteoblast adhesion and differentiation
Open the record for dataset details and reuse information.
RNA seq after RNA pol III manipulation by Brf1 and Maf1 knockdown, Maf1 overexpression and ML60218 treatment in ST2 cells before, and during differentiation into osteoblasts
GEO Series GSE203308. Mus musculus. 48 samples. Type: Expression profiling by high throughput sequencing.
H3.3G34W promotes growth and impedes differentiation of osteoblast-like mesenchymal progenitors in Giant Cell Tumour of Bone [RNA-Seq]
GEO Series GSE149209. Homo sapiens. 38 samples. Type: Expression profiling by high throughput sequencing.
miR-324 regulates both osteoblast and osteoclast differentiation and function to control bone homeostasis
GEO Series GSE226615. Mus musculus. 36 samples. Type: Expression profiling by high throughput sequencing.
H3.3G34W promotes growth and impedes differentiation of osteoblast-like mesenchymal progenitors in Giant Cell Tumour of Bone
GEO Series GSE149211. Homo sapiens. 130 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Inhibitory effects of Fusobacterium nucleatum on osteogenic differentiation of osteoblasts and its molecular mechanism
GEO Series GSE133223. Rattus norvegicus. 36 samples. Type: Expression profiling by high throughput sequencing.
Mouse Osteoblast Differentiation RNA-seq analysis
GEO Series GSE186832. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Zfp462, as a novel stimulating factor of osteoblast differentiation, is associated with the development of age-related bone formation alteration.
GEO Series GSE263732. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Genomic Determinants of Gene Regulation by 1,25-Dihydroxyvitamin D3 During Osteoblast-Lineage Cell Differentiation
GEO Series GSE51515. Mus musculus. 28 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array.
Titanium with nanotopography attenuates the osteoclast-induced disruption of osteoblast differentiation by regulating histone methylation
GEO Series GSE189164. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
RNA-seq in osteoblast differentiation
GEO Series GSE167962. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
H3.3G34W promotes growth and impedes differentiation of osteoblast-like mesenchymal progenitors in giant cell tumour of bone [scRNA-Seq and snRNA-Seq]
GEO Series GSE149201. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
FGFR3 is a positive regulator of osteoblast expansion and differentiation during zebrafish skull vault development
GEO Series GSE144944. Danio rerio. 4 samples. Type: Expression profiling by high throughput sequencing.
The RUNX2 Cistrome in Osteoblasts: Characterization, Downregulation Following Differentiation and Relationship to Gene Expression [ChIP-Seq]
GEO Series GSE41920. Mus musculus. 16 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Effect of verapamil treatment on gene expression of osteoblast differentiated from mouse bone marrow-derived mesenchymal stem cells
GEO Series GSE242742. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Expression Profile of New Marker Genes Involved in Differentiation of Canine Adipose-Derived Stem Cells into Osteoblasts and Chondrocytes
GEO Series GSE280031. Canis lupus familiaris. 12 samples. Type: Expression profiling by high throughput sequencing.
Profiling primary osteoblast transcriptomes during differentiation
GEO Series GSE154991. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
MicroRNA-188 regulates age-related switch between osteoblast and adipocyte differentiation
GEO Series GSE57127. Mus musculus. 6 samples. Type: Non-coding RNA profiling by array.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.